MotifSOX2.H12INVITRO.2.S.B
Gene (human)SOX2
(GeneCards)
Gene synonyms (human)
Gene (mouse)Sox2
Gene synonyms (mouse)Sox-2
LOGO
LOGO (reverse complement)
Motif subtype2
Quality
B
Motif length10
ConsensushWhnCATTvh
GC content31.67%
Information content (bits; total / per base)9.529 / 0.953
Data sourcesHT-SELEX
Aligned words7166

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 38 (216) 0.585 0.717 0.383 0.538 0.608 0.771 1.412 2.331 10.887 51.444
Mouse 116 (745) 0.6 0.713 0.396 0.531 0.583 0.746 1.284 2.116 11.824 34.678

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Non-Methyl HT-SELEX, 5 experiments median 0.68 0.647 0.616 0.597 0.572 0.564
best 0.692 0.66 0.623 0.603 0.575 0.568
TF superclassOther all-alpha-helical DNA-binding domains {4} (TFClass)
TF classHigh-mobility group (HMG) domain factors {4.1} (TFClass)
TF familySOX-related {4.1.1} (TFClass)
TF subfamilyGroup B {4.1.1.2} (TFClass)
TFClass IDTFClass: 4.1.1.2.2
HGNCHGNC:11195
MGIMGI:98364
EntrezGene (human)GeneID:6657
(SSTAR profile)
EntrezGene (mouse)GeneID:20674
(SSTAR profile)
UniProt ID (human)SOX2_HUMAN
UniProt ID (mouse)SOX2_MOUSE
UniProt AC (human)P48431
(TFClass)
UniProt AC (mouse)P48432
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 38 human, 116 mouse
HT-SELEX 5
Methyl-HT-SELEX 0
PCM
ACGT
013720.51092.5767.51585.5
02886.5674.5759.54845.5
033416.0882.0780.02088.0
042032.02280.01298.01556.0
0561.07105.00.00.0
067166.00.00.00.0
070.00.00.07166.0
080.00.00.07166.0
092221.01996.02836.0113.0
102180.251365.25858.252762.25
PFM
ACGT
010.5190.1520.1070.221
020.1240.0940.1060.676
030.4770.1230.1090.291
040.2840.3180.1810.217
050.0090.9910.00.0
061.00.00.00.0
070.00.00.01.0
080.00.00.01.0
090.310.2790.3960.016
100.3040.1910.120.385
PWM
ACGT
010.73-0.494-0.846-0.122
02-0.702-0.975-0.8560.994
030.645-0.707-0.830.153
040.1260.241-0.322-0.141
05-3.3451.377-6.695-6.695
061.385-6.695-6.695-6.695
07-6.695-6.695-6.6951.385
08-6.695-6.695-6.6951.385
090.2150.1080.459-2.745
100.196-0.271-0.7350.433
Standard thresholds
P-value Threshold
0.001 5.395825
0.0005 6.173815
0.0001 7.44219