| Motif | SOX2.H12CORE.2.S.B |
| Gene (human) | SOX2 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Sox2 |
| Gene synonyms (mouse) | Sox-2 |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 2 |
| Quality | B |
| Motif | SOX2.H12CORE.2.S.B |
| Gene (human) | SOX2 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Sox2 |
| Gene synonyms (mouse) | Sox-2 |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 2 |
| Quality | B |
| Motif length | 10 |
| Consensus | hWhnCATTvh |
| GC content | 31.67% |
| Information content (bits; total / per base) | 9.529 / 0.953 |
| Data sources | HT-SELEX |
| Aligned words | 7166 |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 38 (216) | 0.585 | 0.717 | 0.383 | 0.538 | 0.608 | 0.771 | 1.412 | 2.331 | 10.887 | 51.444 |
| Mouse | 116 (745) | 0.6 | 0.713 | 0.396 | 0.531 | 0.583 | 0.746 | 1.284 | 2.116 | 11.824 | 34.678 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Non-Methyl HT-SELEX, 5 experiments | median | 0.68 | 0.647 | 0.616 | 0.597 | 0.572 | 0.564 |
| best | 0.692 | 0.66 | 0.623 | 0.603 | 0.575 | 0.568 | |
| TF superclass | Other all-alpha-helical DNA-binding domains {4} (TFClass) |
| TF class | High-mobility group (HMG) domain factors {4.1} (TFClass) |
| TF family | SOX-related {4.1.1} (TFClass) |
| TF subfamily | Group B {4.1.1.2} (TFClass) |
| TFClass ID | TFClass: 4.1.1.2.2 |
| HGNC | HGNC:11195 |
| MGI | MGI:98364 |
| EntrezGene (human) | GeneID:6657 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:20674 (SSTAR profile) |
| UniProt ID (human) | SOX2_HUMAN |
| UniProt ID (mouse) | SOX2_MOUSE |
| UniProt AC (human) | P48431 (TFClass) |
| UniProt AC (mouse) | P48432 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 38 human, 116 mouse |
| HT-SELEX | 5 |
| Methyl-HT-SELEX | 0 |
| PCM | SOX2.H12CORE.2.S.B.pcm |
| PWM | SOX2.H12CORE.2.S.B.pwm |
| PFM | SOX2.H12CORE.2.S.B.pfm |
| Alignment | SOX2.H12CORE.2.S.B.words.tsv |
| Threshold to P-value map | SOX2.H12CORE.2.S.B.thr |
| Motif in other formats | |
| JASPAR format | SOX2.H12CORE.2.S.B_jaspar_format.txt |
| MEME format | SOX2.H12CORE.2.S.B_meme_format.meme |
| Transfac format | SOX2.H12CORE.2.S.B_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 3720.5 | 1092.5 | 767.5 | 1585.5 |
| 02 | 886.5 | 674.5 | 759.5 | 4845.5 |
| 03 | 3416.0 | 882.0 | 780.0 | 2088.0 |
| 04 | 2032.0 | 2280.0 | 1298.0 | 1556.0 |
| 05 | 61.0 | 7105.0 | 0.0 | 0.0 |
| 06 | 7166.0 | 0.0 | 0.0 | 0.0 |
| 07 | 0.0 | 0.0 | 0.0 | 7166.0 |
| 08 | 0.0 | 0.0 | 0.0 | 7166.0 |
| 09 | 2221.0 | 1996.0 | 2836.0 | 113.0 |
| 10 | 2180.25 | 1365.25 | 858.25 | 2762.25 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.519 | 0.152 | 0.107 | 0.221 |
| 02 | 0.124 | 0.094 | 0.106 | 0.676 |
| 03 | 0.477 | 0.123 | 0.109 | 0.291 |
| 04 | 0.284 | 0.318 | 0.181 | 0.217 |
| 05 | 0.009 | 0.991 | 0.0 | 0.0 |
| 06 | 1.0 | 0.0 | 0.0 | 0.0 |
| 07 | 0.0 | 0.0 | 0.0 | 1.0 |
| 08 | 0.0 | 0.0 | 0.0 | 1.0 |
| 09 | 0.31 | 0.279 | 0.396 | 0.016 |
| 10 | 0.304 | 0.191 | 0.12 | 0.385 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.73 | -0.494 | -0.846 | -0.122 |
| 02 | -0.702 | -0.975 | -0.856 | 0.994 |
| 03 | 0.645 | -0.707 | -0.83 | 0.153 |
| 04 | 0.126 | 0.241 | -0.322 | -0.141 |
| 05 | -3.345 | 1.377 | -6.695 | -6.695 |
| 06 | 1.385 | -6.695 | -6.695 | -6.695 |
| 07 | -6.695 | -6.695 | -6.695 | 1.385 |
| 08 | -6.695 | -6.695 | -6.695 | 1.385 |
| 09 | 0.215 | 0.108 | 0.459 | -2.745 |
| 10 | 0.196 | -0.271 | -0.735 | 0.433 |
| P-value | Threshold |
|---|---|
| 0.001 | 5.395825 |
| 0.0005 | 6.173815 |
| 0.0001 | 7.44219 |