| Motif | SOX10.H12RSNP.0.PSM.A |
| Gene (human) | SOX10 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Sox10 |
| Gene synonyms (mouse) | Sox-10, Sox21 |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | A |
| Motif | SOX10.H12RSNP.0.PSM.A |
| Gene (human) | SOX10 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Sox10 |
| Gene synonyms (mouse) | Sox-10, Sox21 |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | A |
| Motif length | 23 |
| Consensus | ndWMMMWddvvSCATTGTTMhhn |
| GC content | 39.09% |
| Information content (bits; total / per base) | 17.091 / 0.743 |
| Data sources | ChIP-Seq + HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 303 |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 1 (6) | 0.837 | 0.864 | 0.74 | 0.765 | 0.826 | 0.863 | 2.915 | 3.097 | 162.963 | 194.602 |
| Mouse | 1 (6) | 0.757 | 0.83 | 0.661 | 0.716 | 0.75 | 0.803 | 2.363 | 2.689 | 84.199 | 134.959 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 5 experiments | median | 0.996 | 0.995 | 0.897 | 0.903 | 0.72 | 0.754 |
| best | 0.999 | 0.999 | 0.998 | 0.997 | 0.928 | 0.934 | |
| Methyl HT-SELEX, 2 experiments | median | 0.999 | 0.999 | 0.947 | 0.95 | 0.824 | 0.844 |
| best | 0.999 | 0.999 | 0.998 | 0.997 | 0.928 | 0.934 | |
| Non-Methyl HT-SELEX, 3 experiments | median | 0.816 | 0.824 | 0.661 | 0.678 | 0.591 | 0.608 |
| best | 0.996 | 0.995 | 0.916 | 0.917 | 0.735 | 0.767 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 2 | 0.68 | 0.343 | 0.525 | 0.354 |
| TF superclass | Other all-alpha-helical DNA-binding domains {4} (TFClass) |
| TF class | High-mobility group (HMG) domain factors {4.1} (TFClass) |
| TF family | SOX-related {4.1.1} (TFClass) |
| TF subfamily | Group E {4.1.1.5} (TFClass) |
| TFClass ID | TFClass: 4.1.1.5.3 |
| HGNC | HGNC:11190 |
| MGI | MGI:98358 |
| EntrezGene (human) | GeneID:6663 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:20665 (SSTAR profile) |
| UniProt ID (human) | SOX10_HUMAN |
| UniProt ID (mouse) | SOX10_MOUSE |
| UniProt AC (human) | P56693 (TFClass) |
| UniProt AC (mouse) | Q04888 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 1 human, 1 mouse |
| HT-SELEX | 3 |
| Methyl-HT-SELEX | 2 |
| PCM | SOX10.H12RSNP.0.PSM.A.pcm |
| PWM | SOX10.H12RSNP.0.PSM.A.pwm |
| PFM | SOX10.H12RSNP.0.PSM.A.pfm |
| Alignment | SOX10.H12RSNP.0.PSM.A.words.tsv |
| Threshold to P-value map | SOX10.H12RSNP.0.PSM.A.thr |
| Motif in other formats | |
| JASPAR format | SOX10.H12RSNP.0.PSM.A_jaspar_format.txt |
| MEME format | SOX10.H12RSNP.0.PSM.A_meme_format.meme |
| Transfac format | SOX10.H12RSNP.0.PSM.A_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 100.0 | 60.0 | 73.0 | 70.0 |
| 02 | 157.75 | 30.75 | 56.75 | 57.75 |
| 03 | 193.0 | 38.0 | 30.0 | 42.0 |
| 04 | 173.0 | 101.0 | 13.0 | 16.0 |
| 05 | 157.0 | 128.0 | 9.0 | 9.0 |
| 06 | 216.0 | 58.0 | 10.0 | 19.0 |
| 07 | 181.0 | 15.0 | 13.0 | 94.0 |
| 08 | 88.0 | 26.0 | 61.0 | 128.0 |
| 09 | 98.0 | 32.0 | 93.0 | 80.0 |
| 10 | 101.0 | 64.0 | 113.0 | 25.0 |
| 11 | 63.0 | 110.0 | 92.0 | 38.0 |
| 12 | 18.0 | 193.0 | 65.0 | 27.0 |
| 13 | 0.0 | 227.0 | 3.0 | 73.0 |
| 14 | 292.0 | 2.0 | 2.0 | 7.0 |
| 15 | 0.0 | 0.0 | 0.0 | 303.0 |
| 16 | 0.0 | 2.0 | 0.0 | 301.0 |
| 17 | 0.0 | 4.0 | 299.0 | 0.0 |
| 18 | 1.0 | 6.0 | 0.0 | 296.0 |
| 19 | 9.0 | 16.0 | 25.0 | 253.0 |
| 20 | 38.0 | 200.0 | 28.0 | 37.0 |
| 21 | 43.0 | 64.0 | 41.0 | 155.0 |
| 22 | 63.0 | 117.0 | 46.0 | 77.0 |
| 23 | 56.25 | 74.25 | 83.25 | 89.25 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.33 | 0.198 | 0.241 | 0.231 |
| 02 | 0.521 | 0.101 | 0.187 | 0.191 |
| 03 | 0.637 | 0.125 | 0.099 | 0.139 |
| 04 | 0.571 | 0.333 | 0.043 | 0.053 |
| 05 | 0.518 | 0.422 | 0.03 | 0.03 |
| 06 | 0.713 | 0.191 | 0.033 | 0.063 |
| 07 | 0.597 | 0.05 | 0.043 | 0.31 |
| 08 | 0.29 | 0.086 | 0.201 | 0.422 |
| 09 | 0.323 | 0.106 | 0.307 | 0.264 |
| 10 | 0.333 | 0.211 | 0.373 | 0.083 |
| 11 | 0.208 | 0.363 | 0.304 | 0.125 |
| 12 | 0.059 | 0.637 | 0.215 | 0.089 |
| 13 | 0.0 | 0.749 | 0.01 | 0.241 |
| 14 | 0.964 | 0.007 | 0.007 | 0.023 |
| 15 | 0.0 | 0.0 | 0.0 | 1.0 |
| 16 | 0.0 | 0.007 | 0.0 | 0.993 |
| 17 | 0.0 | 0.013 | 0.987 | 0.0 |
| 18 | 0.003 | 0.02 | 0.0 | 0.977 |
| 19 | 0.03 | 0.053 | 0.083 | 0.835 |
| 20 | 0.125 | 0.66 | 0.092 | 0.122 |
| 21 | 0.142 | 0.211 | 0.135 | 0.512 |
| 22 | 0.208 | 0.386 | 0.152 | 0.254 |
| 23 | 0.186 | 0.245 | 0.275 | 0.295 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.273 | -0.228 | -0.036 | -0.077 |
| 02 | 0.724 | -0.875 | -0.283 | -0.266 |
| 03 | 0.924 | -0.672 | -0.898 | -0.575 |
| 04 | 0.815 | 0.283 | -1.677 | -1.488 |
| 05 | 0.719 | 0.517 | -2.002 | -2.002 |
| 06 | 1.036 | -0.261 | -1.91 | -1.329 |
| 07 | 0.86 | -1.547 | -1.677 | 0.212 |
| 08 | 0.147 | -1.035 | -0.212 | 0.517 |
| 09 | 0.253 | -0.837 | 0.202 | 0.054 |
| 10 | 0.283 | -0.165 | 0.394 | -1.072 |
| 11 | -0.181 | 0.367 | 0.191 | -0.672 |
| 12 | -1.379 | 0.924 | -0.15 | -0.999 |
| 13 | -3.99 | 1.085 | -2.858 | -0.036 |
| 14 | 1.336 | -3.114 | -3.114 | -2.215 |
| 15 | -3.99 | -3.99 | -3.99 | 1.372 |
| 16 | -3.99 | -3.114 | -3.99 | 1.366 |
| 17 | -3.99 | -2.654 | 1.359 | -3.99 |
| 18 | -3.459 | -2.341 | -3.99 | 1.349 |
| 19 | -2.002 | -1.488 | -1.072 | 1.193 |
| 20 | -0.672 | 0.959 | -0.964 | -0.697 |
| 21 | -0.552 | -0.165 | -0.598 | 0.706 |
| 22 | -0.181 | 0.428 | -0.487 | 0.016 |
| 23 | -0.291 | -0.02 | 0.093 | 0.161 |
| P-value | Threshold |
|---|---|
| 0.001 | 2.25786 |
| 0.0005 | 3.51486 |
| 0.0001 | 6.14681 |