MotifSOX10.H12INVIVO.2.S.C
Gene (human)SOX10
(GeneCards)
Gene synonyms (human)
Gene (mouse)Sox10
Gene synonyms (mouse)Sox-10, Sox21
LOGO
LOGO (reverse complement)
Motif subtype2
Quality
C
Motif length14
ConsensusnRYTGTTCGSddbn
GC content50.5%
Information content (bits; total / per base)12.699 / 0.907
Data sourcesHT-SELEX
Aligned words2474

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 1 (6) 0.662 0.675 0.481 0.487 0.577 0.594 1.267 1.307 27.677 33.42
Mouse 1 (6) 0.593 0.622 0.424 0.45 0.568 0.589 1.249 1.31 11.825 16.31

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 5 experiments median 0.861 0.817 0.741 0.729 0.651 0.646
best 0.877 0.85 0.818 0.768 0.742 0.706
Methyl HT-SELEX, 2 experiments median 0.849 0.799 0.775 0.731 0.696 0.67
best 0.876 0.827 0.818 0.768 0.742 0.706
Non-Methyl HT-SELEX, 3 experiments median 0.861 0.817 0.741 0.729 0.642 0.646
best 0.877 0.85 0.773 0.735 0.687 0.667

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.555 0.209 0.05 0.007
TF superclassOther all-alpha-helical DNA-binding domains {4} (TFClass)
TF classHigh-mobility group (HMG) domain factors {4.1} (TFClass)
TF familySOX-related {4.1.1} (TFClass)
TF subfamilyGroup E {4.1.1.5} (TFClass)
TFClass IDTFClass: 4.1.1.5.3
HGNCHGNC:11190
MGIMGI:98358
EntrezGene (human)GeneID:6663
(SSTAR profile)
EntrezGene (mouse)GeneID:20665
(SSTAR profile)
UniProt ID (human)SOX10_HUMAN
UniProt ID (mouse)SOX10_MOUSE
UniProt AC (human)P56693
(TFClass)
UniProt AC (mouse)Q04888
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 1 human, 1 mouse
HT-SELEX 3
Methyl-HT-SELEX 2
PCM
ACGT
01548.0651.0564.0711.0
021470.0197.0485.0322.0
03162.0403.0378.01531.0
0420.035.072.02347.0
0521.017.02427.09.0
065.06.022.02441.0
0712.02.036.02424.0
0853.02358.038.025.0
0981.0104.02228.061.0
10152.0338.01648.0336.0
11236.0192.0743.01303.0
12290.0272.01415.0497.0
13358.75372.751152.75589.75
14445.5423.5911.5693.5
PFM
ACGT
010.2220.2630.2280.287
020.5940.080.1960.13
030.0650.1630.1530.619
040.0080.0140.0290.949
050.0080.0070.9810.004
060.0020.0020.0090.987
070.0050.0010.0150.98
080.0210.9530.0150.01
090.0330.0420.9010.025
100.0610.1370.6660.136
110.0950.0780.30.527
120.1170.110.5720.201
130.1450.1510.4660.238
140.180.1710.3680.28
PWM
ACGT
01-0.1210.051-0.0920.139
020.864-1.137-0.242-0.65
03-1.331-0.427-0.490.905
04-3.342-2.821-2.1271.331
05-3.297-3.4881.365-4.037
06-4.491-4.357-3.2541.371
07-3.795-5.056-2.7941.364
08-2.4241.336-2.743-3.136
09-2.012-1.7671.279-2.288
10-1.394-0.6020.978-0.608
11-0.958-1.1630.1830.743
12-0.754-0.8170.826-0.218
13-0.542-0.5040.621-0.047
14-0.327-0.3770.3870.114
Standard thresholds
P-value Threshold
0.001 3.78391
0.0005 4.85856
0.0001 7.11886