MotifSOX10.H12INVITRO.0.PSM.A
Gene (human)SOX10
(GeneCards)
Gene synonyms (human)
Gene (mouse)Sox10
Gene synonyms (mouse)Sox-10, Sox21
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length22
ConsensusnddRvMMWdddbSYATTGTYhn
GC content39.76%
Information content (bits; total / per base)16.2 / 0.736
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words9866

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 1 (6) 0.833 0.853 0.727 0.752 0.819 0.848 2.836 2.995 163.389 198.456
Mouse 1 (6) 0.744 0.81 0.627 0.687 0.729 0.78 2.217 2.5 76.403 123.745

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 5 experiments median 0.996 0.995 0.902 0.908 0.723 0.757
best 0.999 0.999 0.998 0.997 0.932 0.938
Methyl HT-SELEX, 2 experiments median 0.999 0.999 0.95 0.952 0.828 0.847
best 0.999 0.999 0.998 0.997 0.932 0.938
Non-Methyl HT-SELEX, 3 experiments median 0.797 0.811 0.659 0.673 0.589 0.605
best 0.996 0.995 0.906 0.908 0.726 0.759

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.606 0.309 0.497 0.335
TF superclassOther all-alpha-helical DNA-binding domains {4} (TFClass)
TF classHigh-mobility group (HMG) domain factors {4.1} (TFClass)
TF familySOX-related {4.1.1} (TFClass)
TF subfamilyGroup E {4.1.1.5} (TFClass)
TFClass IDTFClass: 4.1.1.5.3
HGNCHGNC:11190
MGIMGI:98358
EntrezGene (human)GeneID:6663
(SSTAR profile)
EntrezGene (mouse)GeneID:20665
(SSTAR profile)
UniProt ID (human)SOX10_HUMAN
UniProt ID (mouse)SOX10_MOUSE
UniProt AC (human)P56693
(TFClass)
UniProt AC (mouse)Q04888
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 1 human, 1 mouse
HT-SELEX 3
Methyl-HT-SELEX 2
PCM
ACGT
012573.52138.53355.51798.5
023178.01546.03504.01638.0
034441.01005.03038.01382.0
045993.0997.01793.01083.0
054823.03302.0919.0822.0
065453.03399.0621.0393.0
076862.01998.0448.0558.0
086109.0447.0454.02856.0
093543.0353.02434.03536.0
102439.0508.04410.02509.0
112711.0897.05071.01187.0
121417.01958.04725.01766.0
13204.04897.03659.01106.0
1478.05707.0179.03902.0
159770.017.054.025.0
1621.03.025.09817.0
172.023.016.09825.0
1814.019.09832.01.0
1959.014.020.09773.0
20425.01102.0875.07464.0
211593.754638.751309.752323.75
221888.252158.252420.253399.25
PFM
ACGT
010.2610.2170.340.182
020.3220.1570.3550.166
030.450.1020.3080.14
040.6070.1010.1820.11
050.4890.3350.0930.083
060.5530.3450.0630.04
070.6960.2030.0450.057
080.6190.0450.0460.289
090.3590.0360.2470.358
100.2470.0510.4470.254
110.2750.0910.5140.12
120.1440.1980.4790.179
130.0210.4960.3710.112
140.0080.5780.0180.395
150.990.0020.0050.003
160.0020.00.0030.995
170.00.0020.0020.996
180.0010.0020.9970.0
190.0060.0010.0020.991
200.0430.1120.0890.757
210.1620.470.1330.236
220.1910.2190.2450.345
PWM
ACGT
010.042-0.1430.308-0.316
020.253-0.4670.351-0.409
030.588-0.8960.208-0.579
040.887-0.904-0.319-0.822
050.670.291-0.986-1.097
060.7930.32-1.376-1.832
071.023-0.21-1.702-1.483
080.906-1.704-1.6880.146
090.362-1.939-0.0130.36
10-0.011-1.5760.5810.017
110.094-1.010.72-0.73
12-0.554-0.2310.65-0.334
13-2.4820.6850.394-0.801
14-3.4260.838-2.6110.458
151.376-4.851-3.781-4.505
16-4.663-6.144-4.5051.381
17-6.353-4.581-4.9051.381
18-5.02-4.7531.382-6.618
19-3.696-5.02-4.7071.376
20-1.754-0.805-1.0351.107
21-0.4360.631-0.632-0.06
22-0.267-0.133-0.0190.32
Standard thresholds
P-value Threshold
0.001 1.42966
0.0005 2.90571
0.0001 6.00686