MotifSOX10.H12CORE.0.PSM.A
Gene (human)SOX10
(GeneCards)
Gene synonyms (human)
Gene (mouse)Sox10
Gene synonyms (mouse)Sox-10, Sox21
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length23
ConsensusndWMMMWddvvSCATTGTTMhhn
GC content39.09%
Information content (bits; total / per base)17.091 / 0.743
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words303

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 1 (6) 0.837 0.864 0.74 0.765 0.826 0.863 2.915 3.097 162.963 194.602
Mouse 1 (6) 0.757 0.83 0.661 0.716 0.75 0.803 2.363 2.689 84.199 134.959

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 5 experiments median 0.996 0.995 0.897 0.903 0.72 0.754
best 0.999 0.999 0.998 0.997 0.928 0.934
Methyl HT-SELEX, 2 experiments median 0.999 0.999 0.947 0.95 0.824 0.844
best 0.999 0.999 0.998 0.997 0.928 0.934
Non-Methyl HT-SELEX, 3 experiments median 0.816 0.824 0.661 0.678 0.591 0.608
best 0.996 0.995 0.916 0.917 0.735 0.767

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.68 0.343 0.525 0.354
TF superclassOther all-alpha-helical DNA-binding domains {4} (TFClass)
TF classHigh-mobility group (HMG) domain factors {4.1} (TFClass)
TF familySOX-related {4.1.1} (TFClass)
TF subfamilyGroup E {4.1.1.5} (TFClass)
TFClass IDTFClass: 4.1.1.5.3
HGNCHGNC:11190
MGIMGI:98358
EntrezGene (human)GeneID:6663
(SSTAR profile)
EntrezGene (mouse)GeneID:20665
(SSTAR profile)
UniProt ID (human)SOX10_HUMAN
UniProt ID (mouse)SOX10_MOUSE
UniProt AC (human)P56693
(TFClass)
UniProt AC (mouse)Q04888
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 1 human, 1 mouse
HT-SELEX 3
Methyl-HT-SELEX 2
PCM
ACGT
01100.060.073.070.0
02157.7530.7556.7557.75
03193.038.030.042.0
04173.0101.013.016.0
05157.0128.09.09.0
06216.058.010.019.0
07181.015.013.094.0
0888.026.061.0128.0
0998.032.093.080.0
10101.064.0113.025.0
1163.0110.092.038.0
1218.0193.065.027.0
130.0227.03.073.0
14292.02.02.07.0
150.00.00.0303.0
160.02.00.0301.0
170.04.0299.00.0
181.06.00.0296.0
199.016.025.0253.0
2038.0200.028.037.0
2143.064.041.0155.0
2263.0117.046.077.0
2356.2574.2583.2589.25
PFM
ACGT
010.330.1980.2410.231
020.5210.1010.1870.191
030.6370.1250.0990.139
040.5710.3330.0430.053
050.5180.4220.030.03
060.7130.1910.0330.063
070.5970.050.0430.31
080.290.0860.2010.422
090.3230.1060.3070.264
100.3330.2110.3730.083
110.2080.3630.3040.125
120.0590.6370.2150.089
130.00.7490.010.241
140.9640.0070.0070.023
150.00.00.01.0
160.00.0070.00.993
170.00.0130.9870.0
180.0030.020.00.977
190.030.0530.0830.835
200.1250.660.0920.122
210.1420.2110.1350.512
220.2080.3860.1520.254
230.1860.2450.2750.295
PWM
ACGT
010.273-0.228-0.036-0.077
020.724-0.875-0.283-0.266
030.924-0.672-0.898-0.575
040.8150.283-1.677-1.488
050.7190.517-2.002-2.002
061.036-0.261-1.91-1.329
070.86-1.547-1.6770.212
080.147-1.035-0.2120.517
090.253-0.8370.2020.054
100.283-0.1650.394-1.072
11-0.1810.3670.191-0.672
12-1.3790.924-0.15-0.999
13-3.991.085-2.858-0.036
141.336-3.114-3.114-2.215
15-3.99-3.99-3.991.372
16-3.99-3.114-3.991.366
17-3.99-2.6541.359-3.99
18-3.459-2.341-3.991.349
19-2.002-1.488-1.0721.193
20-0.6720.959-0.964-0.697
21-0.552-0.165-0.5980.706
22-0.1810.428-0.4870.016
23-0.291-0.020.0930.161
Standard thresholds
P-value Threshold
0.001 2.25786
0.0005 3.51486
0.0001 6.14681