MotifSMAD5.H12INVITRO.0.M.C
Gene (human)SMAD5
(GeneCards)
Gene synonyms (human)MADH5
Gene (mouse)Smad5
Gene synonyms (mouse)Madh5, Msmad5
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
C
Motif length10
ConsensusnCGTCTvvhn
GC content58.57%
Information content (bits; total / per base)9.632 / 0.963
Data sourcesMethyl-HT-SELEX
Aligned words5632

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Methyl HT-SELEX, 1 experiments median 0.797 0.76 0.653 0.652 0.55 0.581
best 0.797 0.76 0.653 0.652 0.55 0.581
TF superclassbeta-Hairpin exposed by an alpha/beta-scaffold {7} (TFClass)
TF classSMAD/NF-1 DNA-binding domain factors {7.1} (TFClass)
TF familySMAD {7.1.1} (TFClass)
TF subfamilyR-MAD {7.1.1.1} (TFClass)
TFClass IDTFClass: 7.1.1.1.4
HGNCHGNC:6771
MGIMGI:1328787
EntrezGene (human)GeneID:4090
(SSTAR profile)
EntrezGene (mouse)GeneID:17129
(SSTAR profile)
UniProt ID (human)SMAD5_HUMAN
UniProt ID (mouse)SMAD5_MOUSE
UniProt AC (human)Q99717
(TFClass)
UniProt AC (mouse)P97454
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 0 human, 0 mouse
HT-SELEX 0
Methyl-HT-SELEX 1
PCM
ACGT
011539.51389.51577.51125.5
0294.04040.042.01456.0
0334.067.05531.00.0
040.0166.00.05466.0
050.05632.00.00.0
060.00.00.05632.0
072110.0788.02440.0294.0
08814.02501.01929.0388.0
091478.752932.75545.75674.75
101202.51891.51514.51023.5
PFM
ACGT
010.2730.2470.280.2
020.0170.7170.0070.259
030.0060.0120.9820.0
040.00.0290.00.971
050.01.00.00.0
060.00.00.01.0
070.3750.140.4330.052
080.1450.4440.3430.069
090.2630.5210.0970.12
100.2140.3360.2690.182
PWM
ACGT
010.089-0.0130.114-0.224
02-2.6851.053-3.4640.033
03-3.664-3.0151.367-6.482
04-6.482-2.127-6.4821.355
05-6.4821.385-6.482-6.482
06-6.482-6.482-6.4821.385
070.404-0.5790.549-1.561
08-0.5470.5740.314-1.285
090.0490.733-0.945-0.734
10-0.1580.2950.073-0.318
Standard thresholds
P-value Threshold
0.001 5.251565
0.0005 6.24098
0.0001 7.529625