MotifSMAD3.H12INVIVO.1.P.B
Gene (human)SMAD3
(GeneCards)
Gene synonyms (human)MADH3
Gene (mouse)Smad3
Gene synonyms (mouse)Madh3
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
B
Motif length9
ConsensusbSCAGACAb
GC content55.63%
Information content (bits; total / per base)10.39 / 1.154
Data sourcesChIP-Seq
Aligned words1000

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 4 (24) 0.783 0.832 0.648 0.688 0.775 0.823 2.163 2.416 63.854 99.036
Mouse 1 (5) 0.63 0.638 0.48 0.491 0.657 0.658 1.68 1.689 15.268 24.244

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Non-Methyl HT-SELEX, 2 experiments median 0.855 0.812 0.74 0.716 0.633 0.637
best 0.891 0.854 0.772 0.749 0.652 0.659
TF superclassbeta-Hairpin exposed by an alpha/beta-scaffold {7} (TFClass)
TF classSMAD/NF-1 DNA-binding domain factors {7.1} (TFClass)
TF familySMAD {7.1.1} (TFClass)
TF subfamilyR-MAD {7.1.1.1} (TFClass)
TFClass IDTFClass: 7.1.1.1.3
HGNCHGNC:6769
MGIMGI:1201674
EntrezGene (human)GeneID:4088
(SSTAR profile)
EntrezGene (mouse)GeneID:17127
(SSTAR profile)
UniProt ID (human)SMAD3_HUMAN
UniProt ID (mouse)SMAD3_MOUSE
UniProt AC (human)P84022
(TFClass)
UniProt AC (mouse)Q8BUN5
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 4 human, 1 mouse
HT-SELEX 2
Methyl-HT-SELEX 0
PCM
ACGT
01139.0318.0187.0356.0
02123.0625.0129.0123.0
0310.0840.014.0136.0
04985.02.07.06.0
0513.012.0975.00.0
06890.062.045.03.0
076.0975.014.05.0
08877.04.024.095.0
0993.0179.0595.0133.0
PFM
ACGT
010.1390.3180.1870.356
020.1230.6250.1290.123
030.010.840.0140.136
040.9850.0020.0070.006
050.0130.0120.9750.0
060.890.0620.0450.003
070.0060.9750.0140.005
080.8770.0040.0240.095
090.0930.1790.5950.133
PWM
ACGT
01-0.5820.239-0.2880.351
02-0.7020.912-0.655-0.702
03-3.0661.207-2.773-0.603
041.366-4.213-3.362-3.484
05-2.839-2.9091.356-4.982
061.265-1.374-1.684-3.975
07-3.4841.356-2.773-3.622
081.25-3.783-2.281-0.956
09-0.977-0.3310.863-0.625
Standard thresholds
P-value Threshold
0.001 4.55956
0.0005 5.62772
0.0001 7.49819