MotifSMAD3.H12CORE.2.P.C
Gene (human)SMAD3
(GeneCards)
Gene synonyms (human)MADH3
Gene (mouse)Smad3
Gene synonyms (mouse)Madh3
LOGO
LOGO (reverse complement)
Motif subtype2
Quality
C
Motif length14
ConsensusvWRSWGnSAGMSWv
GC content55.94%
Information content (bits; total / per base)9.914 / 0.708
Data sourcesChIP-Seq
Aligned words1027

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 4 (24) 0.614 0.742 0.417 0.6 0.629 0.744 1.509 2.357 8.488 55.509
Mouse 1 (5) 0.582 0.585 0.404 0.411 0.602 0.613 1.465 1.488 1.886 3.658

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Non-Methyl HT-SELEX, 2 experiments median 0.621 0.583 0.578 0.557 0.547 0.538
best 0.64 0.598 0.589 0.566 0.555 0.545
TF superclassbeta-Hairpin exposed by an alpha/beta-scaffold {7} (TFClass)
TF classSMAD/NF-1 DNA-binding domain factors {7.1} (TFClass)
TF familySMAD {7.1.1} (TFClass)
TF subfamilyR-MAD {7.1.1.1} (TFClass)
TFClass IDTFClass: 7.1.1.1.3
HGNCHGNC:6769
MGIMGI:1201674
EntrezGene (human)GeneID:4088
(SSTAR profile)
EntrezGene (mouse)GeneID:17127
(SSTAR profile)
UniProt ID (human)SMAD3_HUMAN
UniProt ID (mouse)SMAD3_MOUSE
UniProt AC (human)P84022
(TFClass)
UniProt AC (mouse)Q8BUN5
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 4 human, 1 mouse
HT-SELEX 2
Methyl-HT-SELEX 0
PCM
ACGT
01216.0431.0228.0152.0
02669.059.0146.0153.0
03167.046.0700.0114.0
0452.0278.0661.036.0
05288.027.066.0646.0
0619.033.0955.020.0
07313.0289.0242.0183.0
0861.0598.0254.0114.0
09977.02.012.036.0
1033.028.0948.018.0
11642.0206.0129.050.0
1254.0791.0104.078.0
13637.056.083.0251.0
14199.0221.0450.0157.0
PFM
ACGT
010.210.420.2220.148
020.6510.0570.1420.149
030.1630.0450.6820.111
040.0510.2710.6440.035
050.280.0260.0640.629
060.0190.0320.930.019
070.3050.2810.2360.178
080.0590.5820.2470.111
090.9510.0020.0120.035
100.0320.0270.9230.018
110.6250.2010.1260.049
120.0530.770.1010.076
130.620.0550.0810.244
140.1940.2150.4380.153
PWM
ACGT
01-0.1720.515-0.118-0.52
020.954-1.448-0.559-0.513
03-0.427-1.6890.999-0.804
04-1.5710.0790.942-1.924
050.114-2.197-1.3390.919
06-2.523-2.0071.309-2.476
070.1970.118-0.059-0.336
08-1.4160.842-0.011-0.804
091.331-4.237-2.935-1.924
10-2.007-2.1631.301-2.573
110.912-0.219-0.682-1.609
12-1.5341.121-0.894-1.176
130.905-1.499-1.115-0.022
14-0.253-0.1490.558-0.488
Standard thresholds
P-value Threshold
0.001 4.72251
0.0005 5.53091
0.0001 7.19446