| Motif | SMAD3.H12CORE.1.P.B |
| Gene (human) | SMAD3 (GeneCards) |
| Gene synonyms (human) | MADH3 |
| Gene (mouse) | Smad3 |
| Gene synonyms (mouse) | Madh3 |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 1 |
| Quality | B |
| Motif | SMAD3.H12CORE.1.P.B |
| Gene (human) | SMAD3 (GeneCards) |
| Gene synonyms (human) | MADH3 |
| Gene (mouse) | Smad3 |
| Gene synonyms (mouse) | Madh3 |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 1 |
| Quality | B |
| Motif length | 9 |
| Consensus | bSCAGACAb |
| GC content | 55.63% |
| Information content (bits; total / per base) | 10.39 / 1.154 |
| Data sources | ChIP-Seq |
| Aligned words | 1000 |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 4 (24) | 0.783 | 0.832 | 0.648 | 0.688 | 0.775 | 0.823 | 2.163 | 2.416 | 63.854 | 99.036 |
| Mouse | 1 (5) | 0.63 | 0.638 | 0.48 | 0.491 | 0.657 | 0.658 | 1.68 | 1.689 | 15.268 | 24.244 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Non-Methyl HT-SELEX, 2 experiments | median | 0.855 | 0.812 | 0.74 | 0.716 | 0.633 | 0.637 |
| best | 0.891 | 0.854 | 0.772 | 0.749 | 0.652 | 0.659 | |
| TF superclass | beta-Hairpin exposed by an alpha/beta-scaffold {7} (TFClass) |
| TF class | SMAD/NF-1 DNA-binding domain factors {7.1} (TFClass) |
| TF family | SMAD {7.1.1} (TFClass) |
| TF subfamily | R-MAD {7.1.1.1} (TFClass) |
| TFClass ID | TFClass: 7.1.1.1.3 |
| HGNC | HGNC:6769 |
| MGI | MGI:1201674 |
| EntrezGene (human) | GeneID:4088 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:17127 (SSTAR profile) |
| UniProt ID (human) | SMAD3_HUMAN |
| UniProt ID (mouse) | SMAD3_MOUSE |
| UniProt AC (human) | P84022 (TFClass) |
| UniProt AC (mouse) | Q8BUN5 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 4 human, 1 mouse |
| HT-SELEX | 2 |
| Methyl-HT-SELEX | 0 |
| PCM | SMAD3.H12CORE.1.P.B.pcm |
| PWM | SMAD3.H12CORE.1.P.B.pwm |
| PFM | SMAD3.H12CORE.1.P.B.pfm |
| Alignment | SMAD3.H12CORE.1.P.B.words.tsv |
| Threshold to P-value map | SMAD3.H12CORE.1.P.B.thr |
| Motif in other formats | |
| JASPAR format | SMAD3.H12CORE.1.P.B_jaspar_format.txt |
| MEME format | SMAD3.H12CORE.1.P.B_meme_format.meme |
| Transfac format | SMAD3.H12CORE.1.P.B_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 139.0 | 318.0 | 187.0 | 356.0 |
| 02 | 123.0 | 625.0 | 129.0 | 123.0 |
| 03 | 10.0 | 840.0 | 14.0 | 136.0 |
| 04 | 985.0 | 2.0 | 7.0 | 6.0 |
| 05 | 13.0 | 12.0 | 975.0 | 0.0 |
| 06 | 890.0 | 62.0 | 45.0 | 3.0 |
| 07 | 6.0 | 975.0 | 14.0 | 5.0 |
| 08 | 877.0 | 4.0 | 24.0 | 95.0 |
| 09 | 93.0 | 179.0 | 595.0 | 133.0 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.139 | 0.318 | 0.187 | 0.356 |
| 02 | 0.123 | 0.625 | 0.129 | 0.123 |
| 03 | 0.01 | 0.84 | 0.014 | 0.136 |
| 04 | 0.985 | 0.002 | 0.007 | 0.006 |
| 05 | 0.013 | 0.012 | 0.975 | 0.0 |
| 06 | 0.89 | 0.062 | 0.045 | 0.003 |
| 07 | 0.006 | 0.975 | 0.014 | 0.005 |
| 08 | 0.877 | 0.004 | 0.024 | 0.095 |
| 09 | 0.093 | 0.179 | 0.595 | 0.133 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.582 | 0.239 | -0.288 | 0.351 |
| 02 | -0.702 | 0.912 | -0.655 | -0.702 |
| 03 | -3.066 | 1.207 | -2.773 | -0.603 |
| 04 | 1.366 | -4.213 | -3.362 | -3.484 |
| 05 | -2.839 | -2.909 | 1.356 | -4.982 |
| 06 | 1.265 | -1.374 | -1.684 | -3.975 |
| 07 | -3.484 | 1.356 | -2.773 | -3.622 |
| 08 | 1.25 | -3.783 | -2.281 | -0.956 |
| 09 | -0.977 | -0.331 | 0.863 | -0.625 |
| P-value | Threshold |
|---|---|
| 0.001 | 4.55956 |
| 0.0005 | 5.62772 |
| 0.0001 | 7.49819 |