| Motif | SMAD3.H12CORE.0.S.B |
| Gene (human) | SMAD3 (GeneCards) |
| Gene synonyms (human) | MADH3 |
| Gene (mouse) | Smad3 |
| Gene synonyms (mouse) | Madh3 |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | B |
| Motif | SMAD3.H12CORE.0.S.B |
| Gene (human) | SMAD3 (GeneCards) |
| Gene synonyms (human) | MADH3 |
| Gene (mouse) | Smad3 |
| Gene synonyms (mouse) | Madh3 |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | B |
| Motif length | 11 |
| Consensus | RWCTAGACAbn |
| GC content | 48.18% |
| Information content (bits; total / per base) | 13.89 / 1.263 |
| Data sources | HT-SELEX |
| Aligned words | 6936 |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 4 (24) | 0.792 | 0.835 | 0.648 | 0.711 | 0.735 | 0.776 | 2.114 | 2.345 | 60.184 | 75.328 |
| Mouse | 1 (5) | 0.63 | 0.641 | 0.477 | 0.493 | 0.599 | 0.605 | 1.51 | 1.552 | 8.469 | 15.62 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Non-Methyl HT-SELEX, 2 experiments | median | 0.883 | 0.852 | 0.752 | 0.739 | 0.637 | 0.649 |
| best | 0.919 | 0.897 | 0.788 | 0.777 | 0.657 | 0.673 | |
| TF superclass | beta-Hairpin exposed by an alpha/beta-scaffold {7} (TFClass) |
| TF class | SMAD/NF-1 DNA-binding domain factors {7.1} (TFClass) |
| TF family | SMAD {7.1.1} (TFClass) |
| TF subfamily | R-MAD {7.1.1.1} (TFClass) |
| TFClass ID | TFClass: 7.1.1.1.3 |
| HGNC | HGNC:6769 |
| MGI | MGI:1201674 |
| EntrezGene (human) | GeneID:4088 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:17127 (SSTAR profile) |
| UniProt ID (human) | SMAD3_HUMAN |
| UniProt ID (mouse) | SMAD3_MOUSE |
| UniProt AC (human) | P84022 (TFClass) |
| UniProt AC (mouse) | Q8BUN5 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 4 human, 1 mouse |
| HT-SELEX | 2 |
| Methyl-HT-SELEX | 0 |
| PCM | SMAD3.H12CORE.0.S.B.pcm |
| PWM | SMAD3.H12CORE.0.S.B.pwm |
| PFM | SMAD3.H12CORE.0.S.B.pfm |
| Alignment | SMAD3.H12CORE.0.S.B.words.tsv |
| Threshold to P-value map | SMAD3.H12CORE.0.S.B.thr |
| Motif in other formats | |
| JASPAR format | SMAD3.H12CORE.0.S.B_jaspar_format.txt |
| MEME format | SMAD3.H12CORE.0.S.B_meme_format.meme |
| Transfac format | SMAD3.H12CORE.0.S.B_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 947.5 | 511.5 | 4874.5 | 602.5 |
| 02 | 889.25 | 551.25 | 717.25 | 4778.25 |
| 03 | 33.0 | 6848.0 | 28.0 | 27.0 |
| 04 | 0.0 | 1125.0 | 4.0 | 5807.0 |
| 05 | 6936.0 | 0.0 | 0.0 | 0.0 |
| 06 | 0.0 | 0.0 | 6936.0 | 0.0 |
| 07 | 6936.0 | 0.0 | 0.0 | 0.0 |
| 08 | 0.0 | 6936.0 | 0.0 | 0.0 |
| 09 | 5076.0 | 7.0 | 1701.0 | 152.0 |
| 10 | 638.75 | 734.75 | 2244.75 | 3317.75 |
| 11 | 1309.75 | 1646.75 | 1893.75 | 2085.75 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.137 | 0.074 | 0.703 | 0.087 |
| 02 | 0.128 | 0.079 | 0.103 | 0.689 |
| 03 | 0.005 | 0.987 | 0.004 | 0.004 |
| 04 | 0.0 | 0.162 | 0.001 | 0.837 |
| 05 | 1.0 | 0.0 | 0.0 | 0.0 |
| 06 | 0.0 | 0.0 | 1.0 | 0.0 |
| 07 | 1.0 | 0.0 | 0.0 | 0.0 |
| 08 | 0.0 | 1.0 | 0.0 | 0.0 |
| 09 | 0.732 | 0.001 | 0.245 | 0.022 |
| 10 | 0.092 | 0.106 | 0.324 | 0.478 |
| 11 | 0.189 | 0.237 | 0.273 | 0.301 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.603 | -1.218 | 1.033 | -1.055 |
| 02 | -0.667 | -1.143 | -0.881 | 1.013 |
| 03 | -3.898 | 1.373 | -4.051 | -4.085 |
| 04 | -6.666 | -0.432 | -5.633 | 1.208 |
| 05 | 1.385 | -6.666 | -6.666 | -6.666 |
| 06 | -6.666 | -6.666 | 1.385 | -6.666 |
| 07 | 1.385 | -6.666 | -6.666 | -6.666 |
| 08 | -6.666 | 1.385 | -6.666 | -6.666 |
| 09 | 1.073 | -5.239 | -0.019 | -2.421 |
| 10 | -0.996 | -0.857 | 0.258 | 0.648 |
| 11 | -0.28 | -0.052 | 0.088 | 0.184 |
| P-value | Threshold |
|---|---|
| 0.001 | 1.411325 |
| 0.0005 | 2.998875 |
| 0.0001 | 7.047795 |