MotifSIX2.H12INVIVO.1.M.C
Gene (human)SIX2
(GeneCards)
Gene synonyms (human)
Gene (mouse)Six2
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
C
Motif length15
ConsensusbKWhMYvYGATAYSn
GC content48.64%
Information content (bits; total / per base)13.097 / 0.873
Data sourcesMethyl-HT-SELEX
Aligned words334

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 5 (34) 0.724 0.752 0.598 0.654 0.726 0.762 2.195 2.508 105.221 132.42
Mouse 8 (52) 0.727 0.776 0.61 0.677 0.71 0.759 2.124 2.433 102.09 184.721

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 4 experiments median 0.885 0.836 0.828 0.778 0.754 0.716
best 0.918 0.889 0.848 0.812 0.765 0.737
Methyl HT-SELEX, 2 experiments median 0.896 0.852 0.835 0.789 0.757 0.723
best 0.918 0.889 0.848 0.812 0.765 0.737
Non-Methyl HT-SELEX, 2 experiments median 0.871 0.819 0.812 0.761 0.74 0.702
best 0.896 0.856 0.833 0.789 0.758 0.723

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 3.5 1.187 0.277 0.093

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.672 0.412 0.662 0.492
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyHD-SINE {3.1.6} (TFClass)
TF subfamilySIX1-like {3.1.6.1} (TFClass)
TFClass IDTFClass: 3.1.6.1.2
HGNCHGNC:10888
MGIMGI:102778
EntrezGene (human)GeneID:10736
(SSTAR profile)
EntrezGene (mouse)GeneID:20472
(SSTAR profile)
UniProt ID (human)SIX2_HUMAN
UniProt ID (mouse)SIX2_MOUSE
UniProt AC (human)Q9NPC8
(TFClass)
UniProt AC (mouse)Q62232
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 5 human, 8 mouse
HT-SELEX 2
Methyl-HT-SELEX 2
PCM
ACGT
0142.0135.070.087.0
0230.522.5247.533.5
0384.041.015.0194.0
04178.040.027.089.0
05259.031.017.027.0
0618.0242.036.038.0
0759.088.0153.034.0
082.0168.04.0160.0
093.00.0331.00.0
10329.00.02.03.0
112.011.00.0321.0
12321.09.04.00.0
133.0251.026.054.0
1410.0157.0137.030.0
1561.588.583.5100.5
PFM
ACGT
010.1260.4040.210.26
020.0910.0670.7410.1
030.2510.1230.0450.581
040.5330.120.0810.266
050.7750.0930.0510.081
060.0540.7250.1080.114
070.1770.2630.4580.102
080.0060.5030.0120.479
090.0090.00.9910.0
100.9850.00.0060.009
110.0060.0330.00.961
120.9610.0270.0120.0
130.0090.7510.0780.162
140.030.470.410.09
150.1840.2650.250.301
PWM
ACGT
01-0.670.474-0.1730.04
02-0.978-1.2661.075-0.888
030.006-0.694-1.6420.833
040.748-0.718-1.0940.063
051.12-0.962-1.527-1.094
06-1.4741.053-0.819-0.767
07-0.340.0520.598-0.874
08-3.2030.69-2.7460.642
09-2.949-4.0691.364-4.069
101.358-4.069-3.203-2.949
11-3.203-1.92-4.0691.334
121.334-2.095-2.746-4.069
13-2.9491.089-1.13-0.427
14-2.0040.6230.488-0.994
15-0.30.0570.00.182
Standard thresholds
P-value Threshold
0.001 3.91761
0.0005 4.96291
0.0001 7.10316