MotifSIX2.H12INVITRO.2.SM.B
Gene (human)SIX2
(GeneCards)
Gene synonyms (human)
Gene (mouse)Six2
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype2
Quality
B
Motif length9
ConsensusnbGATACvn
GC content48.47%
Information content (bits; total / per base)8.307 / 0.923
Data sourcesHT-SELEX + Methyl-HT-SELEX
Aligned words9559

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 5 (34) 0.625 0.651 0.436 0.473 0.58 0.605 1.266 1.334 25.296 35.553
Mouse 8 (52) 0.619 0.649 0.436 0.487 0.571 0.607 1.249 1.39 31.747 47.071

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 4 experiments median 0.891 0.842 0.836 0.785 0.769 0.724
best 0.921 0.881 0.869 0.825 0.789 0.755
Methyl HT-SELEX, 2 experiments median 0.903 0.858 0.854 0.805 0.782 0.742
best 0.921 0.881 0.869 0.825 0.789 0.755
Non-Methyl HT-SELEX, 2 experiments median 0.885 0.833 0.828 0.777 0.758 0.718
best 0.896 0.85 0.833 0.786 0.763 0.719

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 1.059 -0.0 0.342 0.109

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.681 0.31 0.54 0.409
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyHD-SINE {3.1.6} (TFClass)
TF subfamilySIX1-like {3.1.6.1} (TFClass)
TFClass IDTFClass: 3.1.6.1.2
HGNCHGNC:10888
MGIMGI:102778
EntrezGene (human)GeneID:10736
(SSTAR profile)
EntrezGene (mouse)GeneID:20472
(SSTAR profile)
UniProt ID (human)SIX2_HUMAN
UniProt ID (mouse)SIX2_MOUSE
UniProt AC (human)Q9NPC8
(TFClass)
UniProt AC (mouse)Q62232
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 5 human, 8 mouse
HT-SELEX 2
Methyl-HT-SELEX 2
PCM
ACGT
012726.01920.03162.01751.0
02414.54170.51120.53853.5
03106.0150.09291.012.0
047539.00.00.02020.0
0597.0496.00.08966.0
069263.0296.00.00.0
0744.07761.0627.01127.0
081102.753630.753989.75835.75
091627.252892.252195.252844.25
PFM
ACGT
010.2850.2010.3310.183
020.0430.4360.1170.403
030.0110.0160.9720.001
040.7890.00.00.211
050.010.0520.00.938
060.9690.0310.00.0
070.0050.8120.0660.118
080.1150.380.4170.087
090.170.3030.230.298
PWM
ACGT
010.132-0.2190.28-0.311
02-1.7470.556-0.7560.477
03-3.095-2.7541.357-5.12
041.148-6.951-6.951-0.168
05-3.182-1.569-6.9511.322
061.354-2.082-6.951-6.951
07-3.9451.177-1.335-0.751
08-0.7720.4180.512-1.049
09-0.3840.191-0.0850.174
Standard thresholds
P-value Threshold
0.001 5.310345
0.0005 6.00888
0.0001 7.314695