MotifSIX1.H12CORE.1.SM.B
Gene (human)SIX1
(GeneCards)
Gene synonyms (human)
Gene (mouse)Six1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
B
Motif length13
ConsensusnhhnYGATACSnn
GC content49.04%
Information content (bits; total / per base)10.85 / 0.835
Data sourcesHT-SELEX + Methyl-HT-SELEX
Aligned words2496

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 3 (18) 0.664 0.707 0.499 0.556 0.631 0.662 1.578 1.755 46.317 64.041

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 4 experiments median 0.928 0.883 0.891 0.845 0.81 0.775
best 0.935 0.898 0.904 0.861 0.834 0.797
Methyl HT-SELEX, 2 experiments median 0.916 0.867 0.867 0.82 0.778 0.747
best 0.933 0.896 0.892 0.849 0.806 0.775
Non-Methyl HT-SELEX, 2 experiments median 0.929 0.884 0.897 0.85 0.824 0.786
best 0.935 0.898 0.904 0.861 0.834 0.797

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.727 0.417 0.73 0.53
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyHD-SINE {3.1.6} (TFClass)
TF subfamilySIX1-like {3.1.6.1} (TFClass)
TFClass IDTFClass: 3.1.6.1.1
HGNCHGNC:10887
MGIMGI:102780
EntrezGene (human)GeneID:6495
(SSTAR profile)
EntrezGene (mouse)GeneID:20471
(SSTAR profile)
UniProt ID (human)SIX1_HUMAN
UniProt ID (mouse)SIX1_MOUSE
UniProt AC (human)Q15475
(TFClass)
UniProt AC (mouse)Q62231
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 3 human, 0 mouse
HT-SELEX 2
Methyl-HT-SELEX 2
PCM
ACGT
01893.25673.25395.25534.25
021060.25600.25327.25508.25
03528.01204.0279.0485.0
04564.0716.0800.0416.0
0514.01172.0109.01201.0
062.01.02491.02.0
072482.00.00.014.0
086.023.01.02466.0
092461.035.00.00.0
101.02191.039.0265.0
11140.01190.01006.0160.0
12383.25945.25510.25657.25
13562.25638.25565.25730.25
PFM
ACGT
010.3580.270.1580.214
020.4250.240.1310.204
030.2120.4820.1120.194
040.2260.2870.3210.167
050.0060.470.0440.481
060.0010.00.9980.001
070.9940.00.00.006
080.0020.0090.00.988
090.9860.0140.00.0
100.00.8780.0160.106
110.0560.4770.4030.064
120.1540.3790.2040.263
130.2250.2560.2260.293
PWM
ACGT
010.3580.076-0.455-0.155
020.529-0.039-0.643-0.204
03-0.1660.656-0.801-0.251
04-0.1010.1370.248-0.404
05-3.6690.629-1.730.653
06-5.064-5.3561.382-5.064
071.378-5.769-5.769-3.669
08-4.365-3.222-5.3561.372
091.37-2.83-5.769-5.769
10-5.3561.254-2.727-0.852
11-1.4840.6440.476-1.352
12-0.4860.414-0.2010.052
13-0.1040.023-0.0990.157
Standard thresholds
P-value Threshold
0.001 4.30691
0.0005 5.65846
0.0001 7.79267