Motif | SIX1.H12CORE.1.SM.B |
Gene (human) | SIX1 (GeneCards) |
Gene synonyms (human) | |
Gene (mouse) | Six1 |
Gene synonyms (mouse) | |
LOGO | |
LOGO (reverse complement) | |
Motif subtype | 1 |
Quality | B |
Motif | SIX1.H12CORE.1.SM.B |
Gene (human) | SIX1 (GeneCards) |
Gene synonyms (human) | |
Gene (mouse) | Six1 |
Gene synonyms (mouse) | |
LOGO | |
LOGO (reverse complement) | |
Motif subtype | 1 |
Quality | B |
Motif length | 13 |
Consensus | nhhnYGATACSnn |
GC content | 49.04% |
Information content (bits; total / per base) | 10.85 / 0.835 |
Data sources | HT-SELEX + Methyl-HT-SELEX |
Aligned words | 2496 |
ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
---|---|---|---|---|---|---|---|---|---|---|---|
Human | 3 (18) | 0.664 | 0.707 | 0.499 | 0.556 | 0.631 | 0.662 | 1.578 | 1.755 | 46.317 | 64.041 |
HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
---|---|---|---|---|---|---|---|
Overall, 4 experiments | median | 0.928 | 0.883 | 0.891 | 0.845 | 0.81 | 0.775 |
best | 0.935 | 0.898 | 0.904 | 0.861 | 0.834 | 0.797 | |
Methyl HT-SELEX, 2 experiments | median | 0.916 | 0.867 | 0.867 | 0.82 | 0.778 | 0.747 |
best | 0.933 | 0.896 | 0.892 | 0.849 | 0.806 | 0.775 | |
Non-Methyl HT-SELEX, 2 experiments | median | 0.929 | 0.884 | 0.897 | 0.85 | 0.824 | 0.786 |
best | 0.935 | 0.898 | 0.904 | 0.861 | 0.834 | 0.797 |
rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
---|---|---|---|---|
batch 2 | 0.727 | 0.417 | 0.73 | 0.53 |
TF superclass | Helix-turn-helix domains {3} (TFClass) |
TF class | Homeo domain factors {3.1} (TFClass) |
TF family | HD-SINE {3.1.6} (TFClass) |
TF subfamily | SIX1-like {3.1.6.1} (TFClass) |
TFClass ID | TFClass: 3.1.6.1.1 |
HGNC | HGNC:10887 |
MGI | MGI:102780 |
EntrezGene (human) | GeneID:6495 (SSTAR profile) |
EntrezGene (mouse) | GeneID:20471 (SSTAR profile) |
UniProt ID (human) | SIX1_HUMAN |
UniProt ID (mouse) | SIX1_MOUSE |
UniProt AC (human) | Q15475 (TFClass) |
UniProt AC (mouse) | Q62231 (TFClass) |
GRECO-DB-TF | yes |
ChIP-Seq | 3 human, 0 mouse |
HT-SELEX | 2 |
Methyl-HT-SELEX | 2 |
PCM | SIX1.H12CORE.1.SM.B.pcm |
PWM | SIX1.H12CORE.1.SM.B.pwm |
PFM | SIX1.H12CORE.1.SM.B.pfm |
Alignment | SIX1.H12CORE.1.SM.B.words.tsv |
Threshold to P-value map | SIX1.H12CORE.1.SM.B.thr |
Motif in other formats | |
JASPAR format | SIX1.H12CORE.1.SM.B_jaspar_format.txt |
MEME format | SIX1.H12CORE.1.SM.B_meme_format.meme |
Transfac format | SIX1.H12CORE.1.SM.B_transfac_format.txt |
Homer format |
A | C | G | T | |
---|---|---|---|---|
01 | 893.25 | 673.25 | 395.25 | 534.25 |
02 | 1060.25 | 600.25 | 327.25 | 508.25 |
03 | 528.0 | 1204.0 | 279.0 | 485.0 |
04 | 564.0 | 716.0 | 800.0 | 416.0 |
05 | 14.0 | 1172.0 | 109.0 | 1201.0 |
06 | 2.0 | 1.0 | 2491.0 | 2.0 |
07 | 2482.0 | 0.0 | 0.0 | 14.0 |
08 | 6.0 | 23.0 | 1.0 | 2466.0 |
09 | 2461.0 | 35.0 | 0.0 | 0.0 |
10 | 1.0 | 2191.0 | 39.0 | 265.0 |
11 | 140.0 | 1190.0 | 1006.0 | 160.0 |
12 | 383.25 | 945.25 | 510.25 | 657.25 |
13 | 562.25 | 638.25 | 565.25 | 730.25 |
A | C | G | T | |
---|---|---|---|---|
01 | 0.358 | 0.27 | 0.158 | 0.214 |
02 | 0.425 | 0.24 | 0.131 | 0.204 |
03 | 0.212 | 0.482 | 0.112 | 0.194 |
04 | 0.226 | 0.287 | 0.321 | 0.167 |
05 | 0.006 | 0.47 | 0.044 | 0.481 |
06 | 0.001 | 0.0 | 0.998 | 0.001 |
07 | 0.994 | 0.0 | 0.0 | 0.006 |
08 | 0.002 | 0.009 | 0.0 | 0.988 |
09 | 0.986 | 0.014 | 0.0 | 0.0 |
10 | 0.0 | 0.878 | 0.016 | 0.106 |
11 | 0.056 | 0.477 | 0.403 | 0.064 |
12 | 0.154 | 0.379 | 0.204 | 0.263 |
13 | 0.225 | 0.256 | 0.226 | 0.293 |
A | C | G | T | |
---|---|---|---|---|
01 | 0.358 | 0.076 | -0.455 | -0.155 |
02 | 0.529 | -0.039 | -0.643 | -0.204 |
03 | -0.166 | 0.656 | -0.801 | -0.251 |
04 | -0.101 | 0.137 | 0.248 | -0.404 |
05 | -3.669 | 0.629 | -1.73 | 0.653 |
06 | -5.064 | -5.356 | 1.382 | -5.064 |
07 | 1.378 | -5.769 | -5.769 | -3.669 |
08 | -4.365 | -3.222 | -5.356 | 1.372 |
09 | 1.37 | -2.83 | -5.769 | -5.769 |
10 | -5.356 | 1.254 | -2.727 | -0.852 |
11 | -1.484 | 0.644 | 0.476 | -1.352 |
12 | -0.486 | 0.414 | -0.201 | 0.052 |
13 | -0.104 | 0.023 | -0.099 | 0.157 |
P-value | Threshold |
---|---|
0.001 | 4.30691 |
0.0005 | 5.65846 |
0.0001 | 7.79267 |