MotifRXRA.H12INVITRO.1.S.C
Gene (human)RXRA
(GeneCards)
Gene synonyms (human)NR2B1
Gene (mouse)Rxra
Gene synonyms (mouse)Nr2b1
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
C
Motif length14
ConsensusnnvRGGTCAWRRSb
GC content51.58%
Information content (bits; total / per base)13.347 / 0.953
Data sourcesHT-SELEX
Aligned words2467

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 9 (58) 0.733 0.801 0.565 0.629 0.696 0.769 1.818 2.149 69.247 105.886
Mouse 47 (263) 0.751 0.861 0.59 0.715 0.708 0.828 1.883 2.476 62.854 198.377

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 7 experiments median 0.901 0.889 0.735 0.74 0.617 0.646
best 0.999 0.999 0.965 0.963 0.784 0.812
Methyl HT-SELEX, 1 experiments median 0.664 0.673 0.579 0.591 0.546 0.555
best 0.664 0.673 0.579 0.591 0.546 0.555
Non-Methyl HT-SELEX, 6 experiments median 0.91 0.9 0.735 0.744 0.621 0.646
best 0.999 0.999 0.965 0.963 0.784 0.812

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 5.459 4.525 0.187 0.116
TF superclassZinc-coordinating DNA-binding domains {2} (TFClass)
TF classNuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF familyRXR-related receptors {2.1.3} (TFClass)
TF subfamilyRXR (NR2B) {2.1.3.1} (TFClass)
TFClass IDTFClass: 2.1.3.1.1
HGNCHGNC:10477
MGIMGI:98214
EntrezGene (human)GeneID:6256
(SSTAR profile)
EntrezGene (mouse)GeneID:20181
(SSTAR profile)
UniProt ID (human)RXRA_HUMAN
UniProt ID (mouse)RXRA_MOUSE
UniProt AC (human)P19793
(TFClass)
UniProt AC (mouse)P28700
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 9 human, 47 mouse
HT-SELEX 6
Methyl-HT-SELEX 1
PCM
ACGT
01542.75908.75466.75548.75
02923.75666.75386.75489.75
03864.25341.251031.25230.25
041681.027.0744.015.0
0513.013.02406.035.0
065.09.02377.076.0
071.03.025.02438.0
080.02425.011.031.0
092389.00.077.01.0
101553.0225.065.0624.0
111805.078.0509.075.0
12453.75113.751765.75133.75
13276.75308.751575.75305.75
14267.0503.0753.0944.0
PFM
ACGT
010.220.3680.1890.222
020.3740.270.1570.199
030.350.1380.4180.093
040.6810.0110.3020.006
050.0050.0050.9750.014
060.0020.0040.9640.031
070.00.0010.010.988
080.00.9830.0040.013
090.9680.00.0310.0
100.630.0910.0260.253
110.7320.0320.2060.03
120.1840.0460.7160.054
130.1120.1250.6390.124
140.1080.2040.3050.383
PWM
ACGT
01-0.1270.387-0.278-0.116
020.4030.078-0.465-0.23
030.336-0.5890.513-0.98
041.001-3.0620.187-3.597
05-3.723-3.7231.359-2.818
06-4.488-4.0341.347-2.072
07-5.345-4.828-3.1341.372
08-5.7581.367-3.866-2.933
091.352-5.758-2.059-5.345
100.922-1.003-2.2240.012
111.072-2.046-0.191-2.084
12-0.306-1.6771.05-1.517
13-0.797-0.6890.936-0.698
14-0.833-0.2030.1990.425
Standard thresholds
P-value Threshold
0.001 3.32326
0.0005 4.53361
0.0001 7.030415