RUNX3.H12RSNP.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	RUNX3.H12RSNP.0.P.B
Gene (human)	RUNX3 (GeneCards)
Gene synonyms (human)	AML2, CBFA3, PEBP2A3
Gene (mouse)	Runx3
Gene synonyms (mouse)	Aml2, Cbfa3, Pebp2a3
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	11
Consensus	bbhTGYGGTYd
GC content	53.07%
Information content (bits; total / per base)	10.827 / 0.984
Data sources	ChIP-Seq
Aligned words	997

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.918	0.929	0.834	0.858	0.895	0.908	3.205	3.341	308.538	362.018
Mouse	15 (95)	0.892	0.951	0.792	0.902	0.878	0.941	3.02	3.724	172.432	270.745

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 5 experiments	median	0.743	0.703	0.624	0.618	0.562	0.571
Non-Methyl HT-SELEX, 5 experiments	best	0.96	0.931	0.844	0.833	0.671	0.702

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	12.917	6.325	0.437	0.43

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Runt domain factors {6.4} (TFClass)
TF family	Runt-related {6.4.1} (TFClass)
TF subfamily	{6.4.1.0} (TFClass)
TFClass ID	TFClass: 6.4.1.0.3
HGNC	HGNC:10473
MGI	MGI:102672
EntrezGene (human)	GeneID:864 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	RUNX3_HUMAN
UniProt ID (mouse)	RUNX3_MOUSE
UniProt AC (human)	Q13761 (TFClass)
UniProt AC (mouse)	Q64131 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 15 mouse
HT-SELEX	5
Methyl-HT-SELEX	0

PCM	RUNX3.H12RSNP.0.P.B.pcm
PWM	RUNX3.H12RSNP.0.P.B.pwm
PFM	RUNX3.H12RSNP.0.P.B.pfm
Alignment	RUNX3.H12RSNP.0.P.B.words.tsv
Threshold to P-value map	RUNX3.H12RSNP.0.P.B.thr
Motif in other formats
JASPAR format	RUNX3.H12RSNP.0.P.B_jaspar_format.txt
MEME format	RUNX3.H12RSNP.0.P.B_meme_format.meme
Transfac format	RUNX3.H12RSNP.0.P.B_transfac_format.txt
Homer format	RUNX3.H12RSNP.0.P.B_homer_format_0.001.txt RUNX3.H12RSNP.0.P.B_homer_format_0.0005.txt RUNX3.H12RSNP.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	158.0	225.0	394.0	220.0
02	97.0	245.0	352.0	303.0
03	116.0	531.0	72.0	278.0
04	29.0	14.0	4.0	950.0
05	6.0	11.0	966.0	14.0
06	18.0	247.0	23.0	709.0
07	1.0	2.0	994.0	0.0
08	3.0	0.0	991.0	3.0
09	4.0	134.0	30.0	829.0
10	58.0	221.0	93.0	625.0
11	302.0	48.0	223.0	424.0

PFM

	A	C	G	T
01	0.158	0.226	0.395	0.221
02	0.097	0.246	0.353	0.304
03	0.116	0.533	0.072	0.279
04	0.029	0.014	0.004	0.953
05	0.006	0.011	0.969	0.014
06	0.018	0.248	0.023	0.711
07	0.001	0.002	0.997	0.0
08	0.003	0.0	0.994	0.003
09	0.004	0.134	0.03	0.831
10	0.058	0.222	0.093	0.627
11	0.303	0.048	0.224	0.425

PWM

	A	C	G	T
01	-0.452	-0.102	0.455	-0.124
02	-0.933	-0.017	0.343	0.194
03	-0.757	0.753	-1.225	0.108
04	-2.1	-2.77	-3.78	1.333
05	-3.481	-2.982	1.35	-2.77
06	-2.543	-0.009	-2.317	1.041
07	-4.522	-4.21	1.378	-4.979
08	-3.972	-4.979	1.375	-3.972
09	-3.78	-0.615	-2.068	1.197
10	-1.436	-0.119	-0.974	0.915
11	0.191	-1.619	-0.11	0.528

Standard thresholds

P-value	Threshold
0.001	4.468075
0.0005	5.529175
0.0001	7.5674