MotifRUNX3.H12INVIVO.2.S.B
Gene (human)RUNX3
(GeneCards)
Gene synonyms (human)AML2, CBFA3, PEBP2A3
Gene (mouse)Runx3
Gene synonyms (mouse)Aml2, Cbfa3, Pebp2a3
LOGO
LOGO (reverse complement)
Motif subtype2
Quality
B
Motif length11
ConsensusnYTGCGGTYdn
GC content49.06%
Information content (bits; total / per base)12.724 / 1.157
Data sourcesHT-SELEX
Aligned words6921

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 1 (7) 0.911 0.925 0.834 0.852 0.888 0.906 3.055 3.185 331.244 388.456
Mouse 15 (95) 0.875 0.946 0.766 0.884 0.85 0.918 2.528 3.054 166.268 270.638

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Non-Methyl HT-SELEX, 5 experiments median 0.772 0.746 0.64 0.641 0.573 0.584
best 0.995 0.993 0.867 0.871 0.693 0.726

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 14.038 6.798 0.507 0.432
TF superclassImmunoglobulin fold {6} (TFClass)
TF classRunt domain factors {6.4} (TFClass)
TF familyRunt-related {6.4.1} (TFClass)
TF subfamily {6.4.1.0} (TFClass)
TFClass IDTFClass: 6.4.1.0.3
HGNCHGNC:10473
MGIMGI:102672
EntrezGene (human)GeneID:864
(SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)RUNX3_HUMAN
UniProt ID (mouse)RUNX3_MOUSE
UniProt AC (human)Q13761
(TFClass)
UniProt AC (mouse)Q64131
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 1 human, 15 mouse
HT-SELEX 5
Methyl-HT-SELEX 0
PCM
ACGT
011311.251486.251361.252762.25
02769.251429.25533.254189.25
0360.0199.010.06652.0
040.00.06921.00.0
050.05575.00.01346.0
060.00.06921.00.0
070.00.06921.00.0
080.00.00.06921.0
09414.0954.0371.05182.0
102386.5428.5888.53217.5
111555.01296.02058.02012.0
PFM
ACGT
010.1890.2150.1970.399
020.1110.2070.0770.605
030.0090.0290.0010.961
040.00.01.00.0
050.00.8060.00.194
060.00.01.00.0
070.00.01.00.0
080.00.00.01.0
090.060.1380.0540.749
100.3450.0620.1280.465
110.2250.1870.2970.291
PWM
ACGT
01-0.277-0.152-0.240.467
02-0.809-0.191-1.1740.884
03-3.327-2.153-4.9551.346
04-6.664-6.6641.385-6.664
05-6.6641.169-6.664-0.251
06-6.664-6.6641.385-6.664
07-6.664-6.6641.385-6.664
08-6.664-6.664-6.6641.385
09-1.426-0.594-1.5351.096
100.321-1.392-0.6650.62
11-0.107-0.2890.1730.151
Standard thresholds
P-value Threshold
0.001 2.29188
0.0005 4.392505
0.0001 7.529035