MotifRUNX3.H12INVIVO.1.S.B
Gene (human)RUNX3
(GeneCards)
Gene synonyms (human)AML2, CBFA3, PEBP2A3
Gene (mouse)Runx3
Gene synonyms (mouse)Aml2, Cbfa3, Pebp2a3
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
B
Motif length19
ConsensusnbYTGCGGTTTbbSSKKKb
GC content51.77%
Information content (bits; total / per base)18.909 / 0.995
Data sourcesHT-SELEX
Aligned words1490

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 1 (7) 0.894 0.908 0.799 0.818 0.826 0.832 2.824 2.889 176.284 202.347
Mouse 15 (95) 0.873 0.916 0.752 0.843 0.806 0.884 2.485 3.0 82.721 170.824

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Non-Methyl HT-SELEX, 5 experiments median 0.733 0.72 0.615 0.621 0.558 0.571
best 0.992 0.992 0.832 0.843 0.664 0.705

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 11.784 5.849 0.499 0.388
TF superclassImmunoglobulin fold {6} (TFClass)
TF classRunt domain factors {6.4} (TFClass)
TF familyRunt-related {6.4.1} (TFClass)
TF subfamily {6.4.1.0} (TFClass)
TFClass IDTFClass: 6.4.1.0.3
HGNCHGNC:10473
MGIMGI:102672
EntrezGene (human)GeneID:864
(SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)RUNX3_HUMAN
UniProt ID (mouse)RUNX3_MOUSE
UniProt AC (human)Q13761
(TFClass)
UniProt AC (mouse)Q64131
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 1 human, 15 mouse
HT-SELEX 5
Methyl-HT-SELEX 0
PCM
ACGT
01280.0379.0359.0472.0
02247.75335.75250.75655.75
03106.0298.098.0988.0
042.024.01.01463.0
050.00.01490.00.0
061.01372.00.0117.0
070.00.01490.00.0
080.00.01490.00.0
090.00.03.01487.0
1022.069.07.01392.0
11237.042.019.01192.0
1291.0180.0522.0697.0
1332.0471.0382.0605.0
1425.0319.0994.0152.0
1517.0516.0837.0120.0
167.085.0940.0458.0
1745.0111.0664.0670.0
18163.5129.5216.5980.5
19220.25282.25279.25708.25
PFM
ACGT
010.1880.2540.2410.317
020.1660.2250.1680.44
030.0710.20.0660.663
040.0010.0160.0010.982
050.00.01.00.0
060.0010.9210.00.079
070.00.01.00.0
080.00.01.00.0
090.00.00.0020.998
100.0150.0460.0050.934
110.1590.0280.0130.8
120.0610.1210.350.468
130.0210.3160.2560.406
140.0170.2140.6670.102
150.0110.3460.5620.081
160.0050.0570.6310.307
170.030.0740.4460.45
180.110.0870.1450.658
190.1480.1890.1870.475
PWM
ACGT
01-0.2840.017-0.0370.236
02-0.405-0.103-0.3930.563
03-1.245-0.222-1.3220.972
04-4.583-2.674-4.8861.364
05-5.323-5.3231.383-5.323
06-4.8861.3-5.323-1.147
07-5.323-5.3231.383-5.323
08-5.323-5.3231.383-5.323
09-5.323-5.323-4.3511.381
10-2.754-1.665-3.7471.315
11-0.449-2.145-2.8891.16
12-1.394-0.7220.3360.624
13-2.4040.2340.0250.483
14-2.636-0.1540.978-0.889
15-2.990.3250.807-1.123
16-3.747-1.4610.9230.206
17-2.079-1.1990.5760.585
18-0.817-1.047-0.5390.965
19-0.522-0.276-0.2870.64
Standard thresholds
P-value Threshold
0.001 -0.52174
0.0005 1.13751
0.0001 4.59996