RUNX3.H12INVIVO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	RUNX3.H12INVIVO.0.P.B
Gene (human)	RUNX3 (GeneCards)
Gene synonyms (human)	AML2, CBFA3, PEBP2A3
Gene (mouse)	Runx3
Gene synonyms (mouse)	Aml2, Cbfa3, Pebp2a3
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	11
Consensus	bbhTGYGGTYd
GC content	53.59%
Information content (bits; total / per base)	10.772 / 0.979
Data sources	ChIP-Seq
Aligned words	989

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.917	0.929	0.835	0.859	0.895	0.908	3.198	3.329	309.638	365.569
Mouse	15 (95)	0.895	0.951	0.796	0.904	0.88	0.941	3.022	3.724	173.824	274.276

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 5 experiments	median	0.745	0.704	0.624	0.619	0.562	0.571
Non-Methyl HT-SELEX, 5 experiments	best	0.961	0.932	0.846	0.834	0.672	0.703

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	12.115	5.91	0.441	0.424

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Runt domain factors {6.4} (TFClass)
TF family	Runt-related {6.4.1} (TFClass)
TF subfamily	{6.4.1.0} (TFClass)
TFClass ID	TFClass: 6.4.1.0.3
HGNC	HGNC:10473
MGI	MGI:102672
EntrezGene (human)	GeneID:864 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	RUNX3_HUMAN
UniProt ID (mouse)	RUNX3_MOUSE
UniProt AC (human)	Q13761 (TFClass)
UniProt AC (mouse)	Q64131 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 15 mouse
HT-SELEX	5
Methyl-HT-SELEX	0

PCM	RUNX3.H12INVIVO.0.P.B.pcm
PWM	RUNX3.H12INVIVO.0.P.B.pwm
PFM	RUNX3.H12INVIVO.0.P.B.pfm
Alignment	RUNX3.H12INVIVO.0.P.B.words.tsv
Threshold to P-value map	RUNX3.H12INVIVO.0.P.B.thr
Motif in other formats
JASPAR format	RUNX3.H12INVIVO.0.P.B_jaspar_format.txt
MEME format	RUNX3.H12INVIVO.0.P.B_meme_format.meme
Transfac format	RUNX3.H12INVIVO.0.P.B_transfac_format.txt
Homer format	RUNX3.H12INVIVO.0.P.B_homer_format_0.001.txt RUNX3.H12INVIVO.0.P.B_homer_format_0.0005.txt RUNX3.H12INVIVO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	150.0	221.0	390.0	228.0
02	95.0	237.0	359.0	298.0
03	119.0	524.0	73.0	273.0
04	24.0	10.0	5.0	950.0
05	7.0	12.0	966.0	4.0
06	19.0	265.0	17.0	688.0
07	3.0	1.0	983.0	2.0
08	3.0	0.0	983.0	3.0
09	5.0	139.0	37.0	808.0
10	64.0	231.0	89.0	605.0
11	295.0	53.0	235.0	406.0

PFM

	A	C	G	T
01	0.152	0.223	0.394	0.231
02	0.096	0.24	0.363	0.301
03	0.12	0.53	0.074	0.276
04	0.024	0.01	0.005	0.961
05	0.007	0.012	0.977	0.004
06	0.019	0.268	0.017	0.696
07	0.003	0.001	0.994	0.002
08	0.003	0.0	0.994	0.003
09	0.005	0.141	0.037	0.817
10	0.065	0.234	0.09	0.612
11	0.298	0.054	0.238	0.411

PWM

	A	C	G	T
01	-0.495	-0.111	0.453	-0.08
02	-0.945	-0.042	0.371	0.186
03	-0.724	0.747	-1.204	0.098
04	-2.27	-3.056	-3.612	1.341
05	-3.351	-2.898	1.358	-3.773
06	-2.486	0.069	-2.588	1.019
07	-3.965	-4.515	1.375	-4.203
08	-3.965	-4.973	1.375	-3.965
09	-3.612	-0.571	-1.861	1.179
10	-1.332	-0.067	-1.01	0.891
11	0.175	-1.515	-0.05	0.493

Standard thresholds

P-value	Threshold
0.001	4.45715
0.0005	5.55484
0.0001	7.597885