RUNX3.H12INVITRO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	RUNX3.H12INVITRO.0.P.B
Gene (human)	RUNX3 (GeneCards)
Gene synonyms (human)	AML2, CBFA3, PEBP2A3
Gene (mouse)	Runx3
Gene synonyms (mouse)	Aml2, Cbfa3, Pebp2a3
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	9
Consensus	hTGTGGTYW
GC content	47.63%
Information content (bits; total / per base)	11.784 / 1.309
Data sources	ChIP-Seq
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.923	0.934	0.843	0.863	0.9	0.915	3.168	3.336	317.252	358.824
Mouse	15 (95)	0.881	0.942	0.773	0.886	0.864	0.928	2.795	3.438	162.921	258.921

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 5 experiments	median	0.747	0.711	0.629	0.623	0.566	0.574
Non-Methyl HT-SELEX, 5 experiments	best	0.969	0.947	0.847	0.841	0.673	0.706

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	8.793	4.992	0.436	0.395

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Runt domain factors {6.4} (TFClass)
TF family	Runt-related {6.4.1} (TFClass)
TF subfamily	{6.4.1.0} (TFClass)
TFClass ID	TFClass: 6.4.1.0.3
HGNC	HGNC:10473
MGI	MGI:102672
EntrezGene (human)	GeneID:864 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	RUNX3_HUMAN
UniProt ID (mouse)	RUNX3_MOUSE
UniProt AC (human)	Q13761 (TFClass)
UniProt AC (mouse)	Q64131 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 15 mouse
HT-SELEX	5
Methyl-HT-SELEX	0

PCM	RUNX3.H12INVITRO.0.P.B.pcm
PWM	RUNX3.H12INVITRO.0.P.B.pwm
PFM	RUNX3.H12INVITRO.0.P.B.pfm
Alignment	RUNX3.H12INVITRO.0.P.B.words.tsv
Threshold to P-value map	RUNX3.H12INVITRO.0.P.B.thr
Motif in other formats
JASPAR format	RUNX3.H12INVITRO.0.P.B_jaspar_format.txt
MEME format	RUNX3.H12INVITRO.0.P.B_meme_format.meme
Transfac format	RUNX3.H12INVITRO.0.P.B_transfac_format.txt
Homer format	RUNX3.H12INVITRO.0.P.B_homer_format_0.001.txt RUNX3.H12INVITRO.0.P.B_homer_format_0.0005.txt RUNX3.H12INVITRO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	106.0	457.0	57.0	380.0
02	28.0	1.0	14.0	957.0
03	0.0	3.0	993.0	4.0
04	9.0	208.0	11.0	772.0
05	4.0	1.0	993.0	2.0
06	1.0	2.0	993.0	4.0
07	2.0	43.0	34.0	921.0
08	12.0	197.0	68.0	723.0
09	246.0	25.0	187.0	542.0

PFM

	A	C	G	T
01	0.106	0.457	0.057	0.38
02	0.028	0.001	0.014	0.957
03	0.0	0.003	0.993	0.004
04	0.009	0.208	0.011	0.772
05	0.004	0.001	0.993	0.002
06	0.001	0.002	0.993	0.004
07	0.002	0.043	0.034	0.921
08	0.012	0.197	0.068	0.723
09	0.246	0.025	0.187	0.542

PWM

	A	C	G	T
01	-0.849	0.6	-1.455	0.416
02	-2.136	-4.525	-2.773	1.337
03	-4.982	-3.975	1.374	-3.783
04	-3.156	-0.183	-2.985	1.123
05	-3.783	-4.525	1.374	-4.213
06	-4.525	-4.213	1.374	-3.783
07	-4.213	-1.728	-1.952	1.299
08	-2.909	-0.236	-1.284	1.057
09	-0.016	-2.243	-0.288	0.77

Standard thresholds

P-value	Threshold
0.001	3.942275
0.0005	5.0521
0.0001	7.543015