MotifRUNX2.H12INVIVO.2.M.C
Gene (human)RUNX2
(GeneCards)
Gene synonyms (human)AML3, CBFA1, OSF2, PEBP2A
Gene (mouse)Runx2
Gene synonyms (mouse)Aml3, Cbfa1, Osf2, Pebp2a
LOGO
LOGO (reverse complement)
Motif subtype2
Quality
C
Motif length18
ConsensusbKKGKKWWYYGTGGTYWn
GC content45.93%
Information content (bits; total / per base)18.561 / 1.031
Data sourcesMethyl-HT-SELEX
Aligned words5894

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 4 (26) 0.858 0.899 0.734 0.801 0.836 0.894 2.773 3.572 76.753 160.886
Mouse 16 (101) 0.809 0.878 0.666 0.774 0.806 0.867 2.643 3.057 78.602 134.638

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 3 experiments median 0.77 0.727 0.667 0.646 0.594 0.593
best 0.993 0.991 0.952 0.943 0.821 0.827
Methyl HT-SELEX, 1 experiments median 0.993 0.991 0.952 0.943 0.821 0.827
best 0.993 0.991 0.952 0.943 0.821 0.827
Non-Methyl HT-SELEX, 2 experiments median 0.728 0.688 0.639 0.62 0.579 0.576
best 0.77 0.727 0.667 0.646 0.594 0.593

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 2.475 1.827 0.192 0.128
TF superclassImmunoglobulin fold {6} (TFClass)
TF classRunt domain factors {6.4} (TFClass)
TF familyRunt-related {6.4.1} (TFClass)
TF subfamily {6.4.1.0} (TFClass)
TFClass IDTFClass: 6.4.1.0.1
HGNCHGNC:10472
MGIMGI:99829
EntrezGene (human)GeneID:860
(SSTAR profile)
EntrezGene (mouse)GeneID:12393
(SSTAR profile)
UniProt ID (human)RUNX2_HUMAN
UniProt ID (mouse)RUNX2_MOUSE
UniProt AC (human)Q13950
(TFClass)
UniProt AC (mouse)Q08775
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 4 human, 16 mouse
HT-SELEX 2
Methyl-HT-SELEX 1
PCM
ACGT
01565.01602.01662.02065.0
02156.75365.754131.751239.75
03197.0503.01663.03531.0
04143.0260.04792.0699.0
05222.0244.04306.01122.0
06377.0306.0907.04304.0
07525.0292.0497.04580.0
081137.0339.0245.04173.0
09392.0699.0241.04562.0
1055.02574.048.03217.0
118.02.05881.03.0
1226.0270.03.05595.0
131.00.05893.00.0
140.00.05893.01.0
153.050.063.05778.0
16278.0879.0146.04591.0
172521.75170.75559.752641.75
181161.01456.01781.01496.0
PFM
ACGT
010.0960.2720.2820.35
020.0270.0620.7010.21
030.0330.0850.2820.599
040.0240.0440.8130.119
050.0380.0410.7310.19
060.0640.0520.1540.73
070.0890.050.0840.777
080.1930.0580.0420.708
090.0670.1190.0410.774
100.0090.4370.0080.546
110.0010.00.9980.001
120.0040.0460.0010.949
130.00.01.00.0
140.00.01.00.0
150.0010.0080.0110.98
160.0470.1490.0250.779
170.4280.0290.0950.448
180.1970.2470.3020.254
PWM
ACGT
01-0.9560.0830.120.337
02-2.228-1.3891.03-0.172
03-2.003-1.0720.1210.873
04-2.319-1.7281.178-0.744
05-1.884-1.7911.071-0.272
06-1.359-1.566-0.4841.071
07-1.029-1.613-1.0841.133
08-0.259-1.464-1.7871.04
09-1.32-0.744-1.8031.129
10-3.2510.557-3.3810.78
11-4.977-5.8691.383-5.654
12-3.959-1.69-5.6541.333
13-6.143-6.5221.385-6.522
14-6.522-6.5221.385-6.143
15-5.654-3.342-3.121.365
16-1.661-0.516-2.2991.135
170.537-2.144-0.9660.583
18-0.238-0.0120.1890.015
Standard thresholds
P-value Threshold
0.001 0.20626
0.0005 1.80381
0.0001 5.08556