MotifRUNX2.H12CORE.1.S.B
Gene (human)RUNX2
(GeneCards)
Gene synonyms (human)AML3, CBFA1, OSF2, PEBP2A
Gene (mouse)Runx2
Gene synonyms (mouse)Aml3, Cbfa1, Osf2, Pebp2a
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
B
Motif length11
ConsensusnhTGCGGTYdn
GC content50.44%
Information content (bits; total / per base)12.002 / 1.091
Data sourcesHT-SELEX
Aligned words6833

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 4 (26) 0.888 0.942 0.773 0.866 0.865 0.909 2.72 3.059 155.403 314.796
Mouse 16 (101) 0.885 0.929 0.781 0.857 0.854 0.903 2.674 3.121 176.699 331.252

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 3 experiments median 0.859 0.828 0.722 0.71 0.624 0.632
best 0.965 0.944 0.929 0.901 0.839 0.82
Methyl HT-SELEX, 1 experiments median 0.965 0.944 0.929 0.901 0.839 0.82
best 0.965 0.944 0.929 0.901 0.839 0.82
Non-Methyl HT-SELEX, 2 experiments median 0.81 0.776 0.688 0.675 0.604 0.609
best 0.859 0.828 0.722 0.71 0.624 0.632

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 6.237 5.196 0.254 0.22
TF superclassImmunoglobulin fold {6} (TFClass)
TF classRunt domain factors {6.4} (TFClass)
TF familyRunt-related {6.4.1} (TFClass)
TF subfamily {6.4.1.0} (TFClass)
TFClass IDTFClass: 6.4.1.0.1
HGNCHGNC:10472
MGIMGI:99829
EntrezGene (human)GeneID:860
(SSTAR profile)
EntrezGene (mouse)GeneID:12393
(SSTAR profile)
UniProt ID (human)RUNX2_HUMAN
UniProt ID (mouse)RUNX2_MOUSE
UniProt AC (human)Q13950
(TFClass)
UniProt AC (mouse)Q08775
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 4 human, 16 mouse
HT-SELEX 2
Methyl-HT-SELEX 1
PCM
ACGT
011593.01176.01525.02539.0
02963.751025.75872.753970.75
03129.0364.0123.06217.0
041.00.06831.01.0
0513.05605.00.01215.0
060.00.06833.00.0
070.00.06833.00.0
085.00.049.06779.0
09473.0909.0628.04823.0
102632.5488.51213.52498.5
111541.51378.52056.51856.5
PFM
ACGT
010.2330.1720.2230.372
020.1410.150.1280.581
030.0190.0530.0180.91
040.00.01.00.0
050.0020.820.00.178
060.00.01.00.0
070.00.01.00.0
080.0010.00.0070.992
090.0690.1330.0920.706
100.3850.0710.1780.366
110.2260.2020.3010.272
PWM
ACGT
01-0.07-0.373-0.1130.396
02-0.571-0.509-0.670.843
03-2.568-1.541-2.6151.291
04-6.279-6.6531.385-6.279
05-4.7231.187-6.653-0.34
06-6.653-6.6531.385-6.653
07-6.653-6.6531.385-6.653
08-5.469-6.653-3.5091.377
09-1.281-0.63-0.9981.037
100.432-1.249-0.3410.38
11-0.103-0.2140.1850.083
Standard thresholds
P-value Threshold
0.001 3.51197
0.0005 5.094195
0.0001 7.560965