RORG.H12INVITRO.1.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	RORG.H12INVITRO.1.PS.A
Gene (human)	RORC (GeneCards)
Gene synonyms (human)	NR1F3, RORG, RZRG
Gene (mouse)	Rorc
Gene synonyms (mouse)	Nr1f3, Rorg, Thor
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	12
Consensus	dMWnKAGGTCAn
GC content	43.51%
Information content (bits; total / per base)	12.875 / 1.073
Data sources	ChIP-Seq + HT-SELEX
Aligned words	9983

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	7 (44)	0.724	0.916	0.69	0.899	0.673	0.901	3.196	4.909	44.602	269.137

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.995	0.993	0.988	0.982	0.957	0.946
Overall, 2 experiments	best	0.997	0.995	0.989	0.985	0.961	0.949
Methyl HT-SELEX, 1 experiments	median	0.997	0.995	0.989	0.985	0.952	0.944
Methyl HT-SELEX, 1 experiments	best	0.997	0.995	0.989	0.985	0.952	0.944
Non-Methyl HT-SELEX, 1 experiments	median	0.994	0.99	0.986	0.979	0.961	0.949
Non-Methyl HT-SELEX, 1 experiments	best	0.994	0.99	0.986	0.979	0.961	0.949

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Thyroid hormone receptor-related {2.1.2} (TFClass)
TF subfamily	ROR (NR1F) {2.1.2.6} (TFClass)
TFClass ID	TFClass: 2.1.2.6.3
HGNC	HGNC:10260
MGI	MGI:104856
EntrezGene (human)	GeneID:6097 (SSTAR profile)
EntrezGene (mouse)	GeneID:19885 (SSTAR profile)
UniProt ID (human)	RORG_HUMAN
UniProt ID (mouse)	RORG_MOUSE
UniProt AC (human)	P51449 (TFClass)
UniProt AC (mouse)	P51450 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 7 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	RORG.H12INVITRO.1.PS.A.pcm
PWM	RORG.H12INVITRO.1.PS.A.pwm
PFM	RORG.H12INVITRO.1.PS.A.pfm
Alignment	RORG.H12INVITRO.1.PS.A.words.tsv
Threshold to P-value map	RORG.H12INVITRO.1.PS.A.thr
Motif in other formats
JASPAR format	RORG.H12INVITRO.1.PS.A_jaspar_format.txt
MEME format	RORG.H12INVITRO.1.PS.A_meme_format.meme
Transfac format	RORG.H12INVITRO.1.PS.A_transfac_format.txt
Homer format	RORG.H12INVITRO.1.PS.A_homer_format_0.001.txt RORG.H12INVITRO.1.PS.A_homer_format_0.0005.txt RORG.H12INVITRO.1.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2399.25	1474.25	2093.25	4016.25
02	5902.25	1981.25	697.25	1402.25
03	6121.0	345.0	809.0	2708.0
04	1379.0	2898.0	3282.0	2424.0
05	428.0	410.0	1166.0	7979.0
06	8662.0	13.0	1308.0	0.0
07	0.0	1.0	9963.0	19.0
08	1.0	0.0	9981.0	1.0
09	5.0	31.0	168.0	9779.0
10	4.0	9794.0	21.0	164.0
11	9293.25	67.25	552.25	70.25
12	2416.75	3278.75	1789.75	2497.75

PFM

	A	C	G	T
01	0.24	0.148	0.21	0.402
02	0.591	0.198	0.07	0.14
03	0.613	0.035	0.081	0.271
04	0.138	0.29	0.329	0.243
05	0.043	0.041	0.117	0.799
06	0.868	0.001	0.131	0.0
07	0.0	0.0	0.998	0.002
08	0.0	0.0	1.0	0.0
09	0.001	0.003	0.017	0.98
10	0.0	0.981	0.002	0.016
11	0.931	0.007	0.055	0.007
12	0.242	0.328	0.179	0.25

PWM

	A	C	G	T
01	-0.039	-0.526	-0.176	0.475
02	0.86	-0.231	-1.273	-0.576
03	0.897	-1.973	-1.125	0.082
04	-0.592	0.149	0.274	-0.029
05	-1.759	-1.802	-0.76	1.162
06	1.244	-5.095	-0.645	-6.989
07	-6.989	-6.629	1.384	-4.764
08	-6.629	-6.989	1.385	-6.629
09	-5.835	-4.318	-2.686	1.365
10	-5.982	1.366	-4.675	-2.709
11	1.314	-3.581	-1.505	-3.539
12	-0.032	0.273	-0.332	0.001

Standard thresholds

P-value	Threshold
0.001	3.157615
0.0005	4.57259
0.0001	7.255295