PO5F1.H12INVIVO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	PO5F1.H12INVIVO.0.P.B
Gene (human)	POU5F1 (GeneCards)
Gene synonyms (human)	OCT3, OCT4, OTF3
Gene (mouse)	Pou5f1
Gene synonyms (mouse)	Oct-3, Oct-4, Otf-3, Otf3
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	17
Consensus	bbYWTTSWhATGCWdAd
GC content	35.41%
Information content (bits; total / per base)	14.108 / 0.83
Data sources	ChIP-Seq
Aligned words	1022

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	27 (161)	0.883	0.976	0.859	0.956	0.903	0.979	4.874	6.358	235.721	487.046
Mouse	124 (789)	0.888	0.977	0.841	0.974	0.898	0.979	4.222	6.335	213.0	532.921

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.968	0.95	0.941	0.915	0.88	0.855
Overall, 2 experiments	best	0.978	0.964	0.96	0.94	0.924	0.898
Methyl HT-SELEX, 1 experiments	median	0.958	0.936	0.921	0.89	0.835	0.812
Methyl HT-SELEX, 1 experiments	best	0.958	0.936	0.921	0.89	0.835	0.812
Non-Methyl HT-SELEX, 1 experiments	median	0.978	0.964	0.96	0.94	0.924	0.898
Non-Methyl HT-SELEX, 1 experiments	best	0.978	0.964	0.96	0.94	0.924	0.898

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	POU {3.1.10} (TFClass)
TF subfamily	POU5 {3.1.10.5} (TFClass)
TFClass ID	TFClass: 3.1.10.5.1
HGNC	HGNC:9221
MGI	MGI:101893
EntrezGene (human)	GeneID:5460 (SSTAR profile)
EntrezGene (mouse)	GeneID:18999 (SSTAR profile)
UniProt ID (human)	PO5F1_HUMAN
UniProt ID (mouse)	PO5F1_MOUSE
UniProt AC (human)	Q01860 (TFClass)
UniProt AC (mouse)	P20263 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	27 human, 124 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	PO5F1.H12INVIVO.0.P.B.pcm
PWM	PO5F1.H12INVIVO.0.P.B.pwm
PFM	PO5F1.H12INVIVO.0.P.B.pfm
Alignment	PO5F1.H12INVIVO.0.P.B.words.tsv
Threshold to P-value map	PO5F1.H12INVIVO.0.P.B.thr
Motif in other formats
JASPAR format	PO5F1.H12INVIVO.0.P.B_jaspar_format.txt
MEME format	PO5F1.H12INVIVO.0.P.B_meme_format.meme
Transfac format	PO5F1.H12INVIVO.0.P.B_transfac_format.txt
Homer format	PO5F1.H12INVIVO.0.P.B_homer_format_0.001.txt PO5F1.H12INVIVO.0.P.B_homer_format_0.0005.txt PO5F1.H12INVIVO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	116.0	257.0	285.0	364.0
02	66.0	490.0	232.0	234.0
03	53.0	606.0	59.0	304.0
04	533.0	33.0	30.0	426.0
05	13.0	38.0	33.0	938.0
06	52.0	14.0	130.0	826.0
07	113.0	300.0	562.0	47.0
08	344.0	9.0	35.0	634.0
09	160.0	258.0	110.0	494.0
10	950.0	11.0	27.0	34.0
11	9.0	6.0	11.0	996.0
12	1.0	5.0	926.0	90.0
13	18.0	824.0	65.0	115.0
14	776.0	20.0	45.0	181.0
15	573.0	98.0	201.0	150.0
16	829.0	42.0	93.0	58.0
17	169.0	136.0	161.0	556.0

PFM

	A	C	G	T
01	0.114	0.251	0.279	0.356
02	0.065	0.479	0.227	0.229
03	0.052	0.593	0.058	0.297
04	0.522	0.032	0.029	0.417
05	0.013	0.037	0.032	0.918
06	0.051	0.014	0.127	0.808
07	0.111	0.294	0.55	0.046
08	0.337	0.009	0.034	0.62
09	0.157	0.252	0.108	0.483
10	0.93	0.011	0.026	0.033
11	0.009	0.006	0.011	0.975
12	0.001	0.005	0.906	0.088
13	0.018	0.806	0.064	0.113
14	0.759	0.02	0.044	0.177
15	0.561	0.096	0.197	0.147
16	0.811	0.041	0.091	0.057
17	0.165	0.133	0.158	0.544

PWM

	A	C	G	T
01	-0.782	0.006	0.109	0.352
02	-1.334	0.648	-0.096	-0.087
03	-1.548	0.86	-1.444	0.173
04	0.732	-2.002	-2.093	0.509
05	-2.86	-1.868	-2.002	1.296
06	-1.566	-2.794	-0.669	1.169
07	-0.807	0.16	0.785	-1.664
08	0.296	-3.177	-1.946	0.905
09	-0.464	0.01	-0.834	0.656
10	1.308	-3.006	-2.192	-1.974
11	-3.177	-3.505	-3.006	1.356
12	-4.545	-3.643	1.283	-1.031
13	-2.568	1.166	-1.349	-0.79
14	1.106	-2.471	-1.706	-0.342
15	0.804	-0.947	-0.238	-0.528
16	1.172	-1.772	-0.999	-1.46
17	-0.41	-0.625	-0.458	0.774

Standard thresholds

P-value	Threshold
0.001	3.52606
0.0005	4.58086
0.0001	6.78836