PO3F4.H12INVIVO.0.SM.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	PO3F4.H12INVIVO.0.SM.D
Gene (human)	POU3F4 (GeneCards)
Gene synonyms (human)	BRN4, OTF9
Gene (mouse)	Pou3f4
Gene synonyms (mouse)	Brn-4, Brn4, Otf9
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	D

Motif length	15
Consensus	nYTMATTWGCATAWh
GC content	29.74%
Information content (bits; total / per base)	19.548 / 1.303
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	7817

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.996	0.995	0.962	0.956	0.861	0.86
Overall, 4 experiments	best	1.0	1.0	0.999	0.999	0.972	0.97
Methyl HT-SELEX, 1 experiments	median	1.0	1.0	0.999	0.999	0.972	0.97
Methyl HT-SELEX, 1 experiments	best	1.0	1.0	0.999	0.999	0.972	0.97
Non-Methyl HT-SELEX, 3 experiments	median	0.995	0.994	0.941	0.934	0.807	0.813
Non-Methyl HT-SELEX, 3 experiments	best	0.997	0.996	0.983	0.978	0.914	0.906

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	POU {3.1.10} (TFClass)
TF subfamily	POU3 {3.1.10.3} (TFClass)
TFClass ID	TFClass: 3.1.10.3.4
HGNC	HGNC:9217
MGI	MGI:101894
EntrezGene (human)	GeneID:5456 (SSTAR profile)
EntrezGene (mouse)	GeneID:18994 (SSTAR profile)
UniProt ID (human)	PO3F4_HUMAN
UniProt ID (mouse)	PO3F4_MOUSE
UniProt AC (human)	P49335 (TFClass)
UniProt AC (mouse)	P62515 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	PO3F4.H12INVIVO.0.SM.D.pcm
PWM	PO3F4.H12INVIVO.0.SM.D.pwm
PFM	PO3F4.H12INVIVO.0.SM.D.pfm
Alignment	PO3F4.H12INVIVO.0.SM.D.words.tsv
Threshold to P-value map	PO3F4.H12INVIVO.0.SM.D.thr
Motif in other formats
JASPAR format	PO3F4.H12INVIVO.0.SM.D_jaspar_format.txt
MEME format	PO3F4.H12INVIVO.0.SM.D_meme_format.meme
Transfac format	PO3F4.H12INVIVO.0.SM.D_transfac_format.txt
Homer format	PO3F4.H12INVIVO.0.SM.D_homer_format_0.001.txt PO3F4.H12INVIVO.0.SM.D_homer_format_0.0005.txt PO3F4.H12INVIVO.0.SM.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1583.0	2822.0	2035.0	1377.0
02	429.0	5636.0	644.0	1108.0
03	242.0	108.0	137.0	7330.0
04	4365.0	3265.0	111.0	76.0
05	7792.0	11.0	10.0	4.0
06	0.0	9.0	5.0	7803.0
07	17.0	10.0	66.0	7724.0
08	4940.0	77.0	0.0	2800.0
09	332.0	75.0	7402.0	8.0
10	6.0	7748.0	17.0	46.0
11	7710.0	23.0	48.0	36.0
12	42.0	61.0	23.0	7691.0
13	7274.0	83.0	203.0	257.0
14	4945.75	1010.75	227.75	1632.75
15	1587.5	1547.5	1452.5	3229.5

PFM

	A	C	G	T
01	0.203	0.361	0.26	0.176
02	0.055	0.721	0.082	0.142
03	0.031	0.014	0.018	0.938
04	0.558	0.418	0.014	0.01
05	0.997	0.001	0.001	0.001
06	0.0	0.001	0.001	0.998
07	0.002	0.001	0.008	0.988
08	0.632	0.01	0.0	0.358
09	0.042	0.01	0.947	0.001
10	0.001	0.991	0.002	0.006
11	0.986	0.003	0.006	0.005
12	0.005	0.008	0.003	0.984
13	0.931	0.011	0.026	0.033
14	0.633	0.129	0.029	0.209
15	0.203	0.198	0.186	0.413

PWM

	A	C	G	T
01	-0.21	0.367	0.04	-0.35
02	-1.512	1.058	-1.108	-0.567
03	-2.081	-2.876	-2.643	1.321
04	0.803	0.513	-2.849	-3.219
05	1.382	-4.996	-5.074	-5.748
06	-6.772	-5.159	-5.599	1.384
07	-4.622	-5.074	-3.356	1.373
08	0.927	-3.206	-6.772	0.359
09	-1.767	-3.232	1.331	-5.253
10	-5.47	1.377	-4.622	-3.703
11	1.372	-4.35	-3.662	-3.935
12	-3.789	-3.432	-4.35	1.369
13	1.313	-3.133	-2.255	-2.021
14	0.928	-0.658	-2.141	-0.18
15	-0.208	-0.233	-0.296	0.502

Standard thresholds

P-value	Threshold
0.001	-1.46569
0.0005	0.23451
0.0001	3.84571