PO3F3.H12CORE.2.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	PO3F3.H12CORE.2.S.B
Gene (human)	POU3F3 (GeneCards)
Gene synonyms (human)	BRN1, OTF8
Gene (mouse)	Pou3f3
Gene synonyms (mouse)	Brn-1, Brn1, Otf8
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	12
Consensus	dbvhTAATTWRn
GC content	24.3%
Information content (bits; total / per base)	11.392 / 0.949
Data sources	HT-SELEX
Aligned words	6799

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	1 (7)	0.661	0.671	0.474	0.482	0.671	0.684	1.906	1.941	44.119	50.721

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 2 experiments	median	0.779	0.727	0.7	0.667	0.627	0.615
Non-Methyl HT-SELEX, 2 experiments	best	0.875	0.818	0.787	0.745	0.681	0.668

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	POU {3.1.10} (TFClass)
TF subfamily	POU3 {3.1.10.3} (TFClass)
TFClass ID	TFClass: 3.1.10.3.3
HGNC	HGNC:9216
MGI	MGI:102564
EntrezGene (human)	GeneID:5455 (SSTAR profile)
EntrezGene (mouse)	GeneID:18993 (SSTAR profile)
UniProt ID (human)	PO3F3_HUMAN
UniProt ID (mouse)	PO3F3_MOUSE
UniProt AC (human)	P20264 (TFClass)
UniProt AC (mouse)	P31361 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 1 mouse
HT-SELEX	2
Methyl-HT-SELEX	0

PCM	PO3F3.H12CORE.2.S.B.pcm
PWM	PO3F3.H12CORE.2.S.B.pwm
PFM	PO3F3.H12CORE.2.S.B.pfm
Alignment	PO3F3.H12CORE.2.S.B.words.tsv
Threshold to P-value map	PO3F3.H12CORE.2.S.B.thr
Motif in other formats
JASPAR format	PO3F3.H12CORE.2.S.B_jaspar_format.txt
MEME format	PO3F3.H12CORE.2.S.B_meme_format.meme
Transfac format	PO3F3.H12CORE.2.S.B_transfac_format.txt
Homer format	PO3F3.H12CORE.2.S.B_homer_format_0.001.txt PO3F3.H12CORE.2.S.B_homer_format_0.0005.txt PO3F3.H12CORE.2.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1672.25	994.25	1063.25	3069.25
02	854.25	1094.25	2673.25	2177.25
03	2360.0	2369.0	1904.0	166.0
04	2209.0	2323.0	301.0	1966.0
05	0.0	0.0	0.0	6799.0
06	6777.0	22.0	0.0	0.0
07	6799.0	0.0	0.0	0.0
08	0.0	0.0	0.0	6799.0
09	0.0	29.0	1267.0	5503.0
10	4961.0	803.0	51.0	984.0
11	3984.5	902.5	1485.5	426.5
12	1978.5	1359.5	1180.5	2280.5

PFM

	A	C	G	T
01	0.246	0.146	0.156	0.451
02	0.126	0.161	0.393	0.32
03	0.347	0.348	0.28	0.024
04	0.325	0.342	0.044	0.289
05	0.0	0.0	0.0	1.0
06	0.997	0.003	0.0	0.0
07	1.0	0.0	0.0	0.0
08	0.0	0.0	0.0	1.0
09	0.0	0.004	0.186	0.809
10	0.73	0.118	0.008	0.145
11	0.586	0.133	0.218	0.063
12	0.291	0.2	0.174	0.335

PWM

	A	C	G	T
01	-0.016	-0.535	-0.468	0.59
02	-0.687	-0.44	0.452	0.247
03	0.328	0.332	0.113	-2.314
04	0.262	0.312	-1.725	0.145
05	-6.648	-6.648	-6.648	1.385
06	1.382	-4.253	-6.648	-6.648
07	1.385	-6.648	-6.648	-6.648
08	-6.648	-6.648	-6.648	1.385
09	-6.648	-3.999	-0.293	1.174
10	1.07	-0.748	-3.465	-0.546
11	0.851	-0.632	-0.135	-1.379
12	0.152	-0.223	-0.364	0.294

Standard thresholds

P-value	Threshold
0.001	3.987275
0.0005	5.62935
0.0001	7.704395