PO3F2.H12INVITRO.2.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	PO3F2.H12INVITRO.2.SM.B
Gene (human)	POU3F2 (GeneCards)
Gene synonyms (human)	BRN2, OCT7, OTF7
Gene (mouse)	Pou3f2
Gene synonyms (mouse)	Brn-2, Brn2, Otf7
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	15
Consensus	nvYTMATTAGCATWh
GC content	32.32%
Information content (bits; total / per base)	16.281 / 1.085
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	4602

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (15)	0.458	0.468	0.313	0.323	0.417	0.43	0.865	0.919	0.009	0.495
Mouse	8 (51)	0.609	0.668	0.449	0.542	0.562	0.64	1.539	1.934	15.137	40.301

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.905	0.896	0.835	0.828	0.772	0.768
Overall, 4 experiments	best	0.999	0.998	0.99	0.987	0.947	0.939
Methyl HT-SELEX, 1 experiments	median	0.999	0.998	0.99	0.987	0.947	0.939
Methyl HT-SELEX, 1 experiments	best	0.999	0.998	0.99	0.987	0.947	0.939
Non-Methyl HT-SELEX, 3 experiments	median	0.816	0.799	0.69	0.684	0.608	0.615
Non-Methyl HT-SELEX, 3 experiments	best	0.995	0.992	0.98	0.973	0.935	0.922

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	POU {3.1.10} (TFClass)
TF subfamily	POU3 {3.1.10.3} (TFClass)
TFClass ID	TFClass: 3.1.10.3.2
HGNC	HGNC:9215
MGI	MGI:101895
EntrezGene (human)	GeneID:5454 (SSTAR profile)
EntrezGene (mouse)	GeneID:18992 (SSTAR profile)
UniProt ID (human)	PO3F2_HUMAN
UniProt ID (mouse)	PO3F2_MOUSE
UniProt AC (human)	P20265 (TFClass)
UniProt AC (mouse)	P31360 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 8 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	PO3F2.H12INVITRO.2.SM.B.pcm
PWM	PO3F2.H12INVITRO.2.SM.B.pwm
PFM	PO3F2.H12INVITRO.2.SM.B.pfm
Alignment	PO3F2.H12INVITRO.2.SM.B.words.tsv
Threshold to P-value map	PO3F2.H12INVITRO.2.SM.B.thr
Motif in other formats
JASPAR format	PO3F2.H12INVITRO.2.SM.B_jaspar_format.txt
MEME format	PO3F2.H12INVITRO.2.SM.B_meme_format.meme
Transfac format	PO3F2.H12INVITRO.2.SM.B_transfac_format.txt
Homer format	PO3F2.H12INVITRO.2.SM.B_homer_format_0.001.txt PO3F2.H12INVITRO.2.SM.B_homer_format_0.0005.txt PO3F2.H12INVITRO.2.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1558.25	1115.25	1141.25	787.25
02	1082.75	1802.75	1182.75	533.75
03	298.0	2823.0	692.0	789.0
04	189.0	72.0	204.0	4137.0
05	3098.0	1434.0	59.0	11.0
06	4599.0	2.0	1.0	0.0
07	0.0	0.0	0.0	4602.0
08	0.0	0.0	1.0	4601.0
09	3771.0	0.0	1.0	830.0
10	367.0	138.0	3882.0	215.0
11	3.0	4256.0	219.0	124.0
12	3991.0	287.0	245.0	79.0
13	271.0	234.0	64.0	4033.0
14	3077.5	327.5	505.5	691.5
15	2026.5	1206.5	412.5	956.5

PFM

	A	C	G	T
01	0.339	0.242	0.248	0.171
02	0.235	0.392	0.257	0.116
03	0.065	0.613	0.15	0.171
04	0.041	0.016	0.044	0.899
05	0.673	0.312	0.013	0.002
06	0.999	0.0	0.0	0.0
07	0.0	0.0	0.0	1.0
08	0.0	0.0	0.0	1.0
09	0.819	0.0	0.0	0.18
10	0.08	0.03	0.844	0.047
11	0.001	0.925	0.048	0.027
12	0.867	0.062	0.053	0.017
13	0.059	0.051	0.014	0.876
14	0.669	0.071	0.11	0.15
15	0.44	0.262	0.09	0.208

PWM

	A	C	G	T
01	0.303	-0.031	-0.008	-0.379
02	-0.061	0.448	0.028	-0.766
03	-1.346	0.897	-0.507	-0.376
04	-1.797	-2.744	-1.721	1.278
05	0.989	0.22	-2.937	-4.477
06	1.384	-5.637	-5.916	-6.304
07	-6.304	-6.304	-6.304	1.385
08	-6.304	-6.304	-5.916	1.385
09	1.186	-6.304	-5.916	-0.326
10	-1.139	-2.107	1.215	-1.669
11	-5.419	1.307	-1.651	-2.213
12	1.243	-1.383	-1.54	-2.654
13	-1.44	-1.585	-2.858	1.253
14	0.983	-1.252	-0.82	-0.508
15	0.565	0.047	-1.022	-0.184

Standard thresholds

P-value	Threshold
0.001	1.44721
0.0005	2.98161
0.0001	6.03706