PO3F2.H12INVITRO.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	PO3F2.H12INVITRO.1.S.B
Gene (human)	POU3F2 (GeneCards)
Gene synonyms (human)	BRN2, OCT7, OTF7
Gene (mouse)	Pou3f2
Gene synonyms (mouse)	Brn-2, Brn2, Otf7
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	14
Consensus	nhbWMATTAdbhhh
GC content	28.66%
Information content (bits; total / per base)	9.915 / 0.708
Data sources	HT-SELEX
Aligned words	9696

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (15)	0.503	0.534	0.342	0.359	0.466	0.487	1.03	1.096	11.42	27.824
Mouse	8 (51)	0.645	0.705	0.446	0.53	0.589	0.687	1.478	1.921	24.523	77.194

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.891	0.862	0.823	0.801	0.764	0.75
Overall, 4 experiments	best	0.984	0.974	0.971	0.956	0.946	0.925
Methyl HT-SELEX, 1 experiments	median	0.984	0.974	0.971	0.956	0.946	0.925
Methyl HT-SELEX, 1 experiments	best	0.984	0.974	0.971	0.956	0.946	0.925
Non-Methyl HT-SELEX, 3 experiments	median	0.813	0.775	0.693	0.676	0.607	0.611
Non-Methyl HT-SELEX, 3 experiments	best	0.969	0.949	0.952	0.925	0.921	0.89

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	POU {3.1.10} (TFClass)
TF subfamily	POU3 {3.1.10.3} (TFClass)
TFClass ID	TFClass: 3.1.10.3.2
HGNC	HGNC:9215
MGI	MGI:101895
EntrezGene (human)	GeneID:5454 (SSTAR profile)
EntrezGene (mouse)	GeneID:18992 (SSTAR profile)
UniProt ID (human)	PO3F2_HUMAN
UniProt ID (mouse)	PO3F2_MOUSE
UniProt AC (human)	P20265 (TFClass)
UniProt AC (mouse)	P31360 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 8 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	PO3F2.H12INVITRO.1.S.B.pcm
PWM	PO3F2.H12INVITRO.1.S.B.pwm
PFM	PO3F2.H12INVITRO.1.S.B.pfm
Alignment	PO3F2.H12INVITRO.1.S.B.words.tsv
Threshold to P-value map	PO3F2.H12INVITRO.1.S.B.thr
Motif in other formats
JASPAR format	PO3F2.H12INVITRO.1.S.B_jaspar_format.txt
MEME format	PO3F2.H12INVITRO.1.S.B_meme_format.meme
Transfac format	PO3F2.H12INVITRO.1.S.B_transfac_format.txt
Homer format	PO3F2.H12INVITRO.1.S.B_homer_format_0.001.txt PO3F2.H12INVITRO.1.S.B_homer_format_0.0005.txt PO3F2.H12INVITRO.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	3219.25	2792.25	1606.25	2078.25
02	4405.0	1885.0	1610.0	1796.0
03	998.0	2717.0	1226.0	4755.0
04	1651.0	466.0	1366.0	6213.0
05	6737.0	2725.0	179.0	55.0
06	9547.0	120.0	26.0	3.0
07	0.0	13.0	0.0	9683.0
08	219.0	0.0	5.0	9472.0
09	7958.0	403.0	1.0	1334.0
10	1914.0	1095.0	3784.0	2903.0
11	491.0	4803.0	2694.0	1708.0
12	4033.0	3312.0	993.0	1358.0
13	2805.75	1274.75	947.75	4667.75
14	3873.0	1496.0	1371.0	2956.0

PFM

	A	C	G	T
01	0.332	0.288	0.166	0.214
02	0.454	0.194	0.166	0.185
03	0.103	0.28	0.126	0.49
04	0.17	0.048	0.141	0.641
05	0.695	0.281	0.018	0.006
06	0.985	0.012	0.003	0.0
07	0.0	0.001	0.0	0.999
08	0.023	0.0	0.001	0.977
09	0.821	0.042	0.0	0.138
10	0.197	0.113	0.39	0.299
11	0.051	0.495	0.278	0.176
12	0.416	0.342	0.102	0.14
13	0.289	0.131	0.098	0.481
14	0.399	0.154	0.141	0.305

PWM

	A	C	G	T
01	0.283	0.141	-0.411	-0.154
02	0.597	-0.251	-0.409	-0.3
03	-0.886	0.114	-0.681	0.673
04	-0.384	-1.645	-0.573	0.941
05	1.022	0.117	-2.594	-3.746
06	1.37	-2.988	-4.451	-6.127
07	-6.963	-5.067	-6.963	1.384
08	-2.395	-6.963	-5.807	1.362
09	1.188	-1.79	-6.602	-0.596
10	-0.236	-0.794	0.445	0.18
11	-1.593	0.683	0.106	-0.35
12	0.509	0.312	-0.891	-0.579
13	0.146	-0.642	-0.938	0.655
14	0.468	-0.482	-0.569	0.198

Standard thresholds

P-value	Threshold
0.001	4.95866
0.0005	5.84761
0.0001	7.43331