PO3F2.H12CORE.2.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	PO3F2.H12CORE.2.SM.B
Gene (human)	POU3F2 (GeneCards)
Gene synonyms (human)	BRN2, OCT7, OTF7
Gene (mouse)	Pou3f2
Gene synonyms (mouse)	Brn-2, Brn2, Otf7
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	16
Consensus	nvCTMATTAGCATAMh
GC content	33.68%
Information content (bits; total / per base)	18.185 / 1.137
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	5430

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (15)	0.478	0.5	0.323	0.332	0.415	0.444	0.853	0.943	0.131	0.959
Mouse	8 (51)	0.637	0.704	0.469	0.545	0.582	0.653	1.599	1.935	11.585	40.959

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.904	0.894	0.834	0.827	0.771	0.767
Overall, 4 experiments	best	0.999	0.999	0.99	0.987	0.944	0.936
Methyl HT-SELEX, 1 experiments	median	0.999	0.999	0.99	0.987	0.944	0.936
Methyl HT-SELEX, 1 experiments	best	0.999	0.999	0.99	0.987	0.944	0.936
Non-Methyl HT-SELEX, 3 experiments	median	0.813	0.796	0.688	0.682	0.608	0.614
Non-Methyl HT-SELEX, 3 experiments	best	0.995	0.992	0.979	0.972	0.933	0.92

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	POU {3.1.10} (TFClass)
TF subfamily	POU3 {3.1.10.3} (TFClass)
TFClass ID	TFClass: 3.1.10.3.2
HGNC	HGNC:9215
MGI	MGI:101895
EntrezGene (human)	GeneID:5454 (SSTAR profile)
EntrezGene (mouse)	GeneID:18992 (SSTAR profile)
UniProt ID (human)	PO3F2_HUMAN
UniProt ID (mouse)	PO3F2_MOUSE
UniProt AC (human)	P20265 (TFClass)
UniProt AC (mouse)	P31360 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 8 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	PO3F2.H12CORE.2.SM.B.pcm
PWM	PO3F2.H12CORE.2.SM.B.pwm
PFM	PO3F2.H12CORE.2.SM.B.pfm
Alignment	PO3F2.H12CORE.2.SM.B.words.tsv
Threshold to P-value map	PO3F2.H12CORE.2.SM.B.thr
Motif in other formats
JASPAR format	PO3F2.H12CORE.2.SM.B_jaspar_format.txt
MEME format	PO3F2.H12CORE.2.SM.B_meme_format.meme
Transfac format	PO3F2.H12CORE.2.SM.B_transfac_format.txt
Homer format	PO3F2.H12CORE.2.SM.B_homer_format_0.001.txt PO3F2.H12CORE.2.SM.B_homer_format_0.0005.txt PO3F2.H12CORE.2.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1928.5	1507.5	1084.5	909.5
02	835.5	2738.5	1160.5	695.5
03	197.0	4382.0	363.0	488.0
04	106.0	87.0	90.0	5147.0
05	2604.0	2787.0	36.0	3.0
06	5427.0	2.0	1.0	0.0
07	0.0	1.0	0.0	5429.0
08	5.0	4.0	8.0	5413.0
09	4253.0	8.0	0.0	1169.0
10	515.0	301.0	4458.0	156.0
11	9.0	5121.0	176.0	124.0
12	4918.0	216.0	198.0	98.0
13	101.0	274.0	76.0	4979.0
14	4431.0	213.0	448.0	338.0
15	3212.0	1044.0	270.0	904.0
16	1016.75	1229.75	977.75	2205.75

PFM

	A	C	G	T
01	0.355	0.278	0.2	0.167
02	0.154	0.504	0.214	0.128
03	0.036	0.807	0.067	0.09
04	0.02	0.016	0.017	0.948
05	0.48	0.513	0.007	0.001
06	0.999	0.0	0.0	0.0
07	0.0	0.0	0.0	1.0
08	0.001	0.001	0.001	0.997
09	0.783	0.001	0.0	0.215
10	0.095	0.055	0.821	0.029
11	0.002	0.943	0.032	0.023
12	0.906	0.04	0.036	0.018
13	0.019	0.05	0.014	0.917
14	0.816	0.039	0.083	0.062
15	0.592	0.192	0.05	0.166
16	0.187	0.226	0.18	0.406

PWM

	A	C	G	T
01	0.351	0.105	-0.224	-0.4
02	-0.484	0.701	-0.157	-0.667
03	-1.921	1.171	-1.315	-1.02
04	-2.531	-2.725	-2.692	1.332
05	0.651	0.719	-3.573	-5.576
06	1.385	-5.792	-6.068	-6.45
07	-6.45	-6.068	-6.45	1.385
08	-5.248	-5.399	-4.898	1.382
09	1.141	-4.898	-6.45	-0.149
10	-0.967	-1.501	1.188	-2.151
11	-4.804	1.327	-2.032	-2.378
12	1.286	-1.83	-1.916	-2.608
13	-2.579	-1.594	-2.856	1.298
14	1.182	-1.844	-1.105	-1.386
15	0.86	-0.262	-1.609	-0.406
16	-0.289	-0.099	-0.328	0.485

Standard thresholds

P-value	Threshold
0.001	0.27976
0.0005	1.86406
0.0001	5.12986