PO3F2.H12CORE.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	PO3F2.H12CORE.1.S.B
Gene (human)	POU3F2 (GeneCards)
Gene synonyms (human)	BRN2, OCT7, OTF7
Gene (mouse)	Pou3f2
Gene synonyms (mouse)	Brn-2, Brn2, Otf7
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	15
Consensus	ndhRYTAATTAdbhd
GC content	28.13%
Information content (bits; total / per base)	12.407 / 0.827
Data sources	HT-SELEX
Aligned words	665

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (15)	0.551	0.572	0.395	0.412	0.441	0.487	1.029	1.177	27.886	51.959
Mouse	8 (51)	0.661	0.735	0.468	0.551	0.574	0.691	1.45	1.94	50.301	106.658

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.881	0.847	0.818	0.79	0.76	0.74
Overall, 4 experiments	best	0.975	0.958	0.962	0.94	0.935	0.908
Methyl HT-SELEX, 1 experiments	median	0.975	0.958	0.962	0.94	0.935	0.908
Methyl HT-SELEX, 1 experiments	best	0.975	0.958	0.962	0.94	0.935	0.908
Non-Methyl HT-SELEX, 3 experiments	median	0.803	0.76	0.695	0.671	0.614	0.611
Non-Methyl HT-SELEX, 3 experiments	best	0.96	0.934	0.94	0.908	0.906	0.869

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	POU {3.1.10} (TFClass)
TF subfamily	POU3 {3.1.10.3} (TFClass)
TFClass ID	TFClass: 3.1.10.3.2
HGNC	HGNC:9215
MGI	MGI:101895
EntrezGene (human)	GeneID:5454 (SSTAR profile)
EntrezGene (mouse)	GeneID:18992 (SSTAR profile)
UniProt ID (human)	PO3F2_HUMAN
UniProt ID (mouse)	PO3F2_MOUSE
UniProt AC (human)	P20265 (TFClass)
UniProt AC (mouse)	P31360 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 8 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	PO3F2.H12CORE.1.S.B.pcm
PWM	PO3F2.H12CORE.1.S.B.pwm
PFM	PO3F2.H12CORE.1.S.B.pfm
Alignment	PO3F2.H12CORE.1.S.B.words.tsv
Threshold to P-value map	PO3F2.H12CORE.1.S.B.thr
Motif in other formats
JASPAR format	PO3F2.H12CORE.1.S.B_jaspar_format.txt
MEME format	PO3F2.H12CORE.1.S.B_meme_format.meme
Transfac format	PO3F2.H12CORE.1.S.B_transfac_format.txt
Homer format	PO3F2.H12CORE.1.S.B_homer_format_0.001.txt PO3F2.H12CORE.1.S.B_homer_format_0.0005.txt PO3F2.H12CORE.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	147.25	148.25	151.25	218.25
02	158.75	66.75	284.75	154.75
03	260.0	214.0	72.0	119.0
04	387.0	59.0	167.0	52.0
05	10.0	134.0	50.0	471.0
06	76.0	0.0	75.0	514.0
07	587.0	76.0	1.0	1.0
08	664.0	0.0	1.0	0.0
09	0.0	0.0	0.0	665.0
10	0.0	0.0	32.0	633.0
11	661.0	1.0	3.0	0.0
12	157.0	71.0	179.0	258.0
13	41.0	228.0	282.0	114.0
14	192.5	266.5	73.5	132.5
15	276.0	83.0	87.0	219.0

PFM

	A	C	G	T
01	0.221	0.223	0.227	0.328
02	0.239	0.1	0.428	0.233
03	0.391	0.322	0.108	0.179
04	0.582	0.089	0.251	0.078
05	0.015	0.202	0.075	0.708
06	0.114	0.0	0.113	0.773
07	0.883	0.114	0.002	0.002
08	0.998	0.0	0.002	0.0
09	0.0	0.0	0.0	1.0
10	0.0	0.0	0.048	0.952
11	0.994	0.002	0.005	0.0
12	0.236	0.107	0.269	0.388
13	0.062	0.343	0.424	0.171
14	0.289	0.401	0.111	0.199
15	0.415	0.125	0.131	0.329

PWM

	A	C	G	T
01	-0.12	-0.113	-0.094	0.27
02	-0.046	-0.898	0.534	-0.071
03	0.444	0.25	-0.824	-0.331
04	0.839	-1.019	0.004	-1.141
05	-2.67	-0.213	-1.179	1.035
06	-0.771	-4.638	-0.784	1.122
07	1.255	-0.771	-4.158	-4.158
08	1.378	-4.638	-4.158	-4.638
09	-4.638	-4.638	-4.638	1.379
10	-4.638	-4.638	-1.608	1.33
11	1.373	-4.158	-3.592	-4.638
12	-0.057	-0.838	0.073	0.436
13	-1.371	0.313	0.524	-0.373
14	0.145	0.468	-0.804	-0.224
15	0.503	-0.685	-0.639	0.273

Standard thresholds

P-value	Threshold
0.001	3.83191
0.0005	5.07841
0.0001	7.40756