PO3F1.H12RSNP.3.M.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	PO3F1.H12RSNP.3.M.D
Gene (human)	POU3F1 (GeneCards)
Gene synonyms (human)	OCT6, OTF6
Gene (mouse)	Pou3f1
Gene synonyms (mouse)	Oct6, Otf-6, Otf6, Scip
LOGO
LOGO (reverse complement)
Motif subtype	3
Quality	D

Motif length	17
Consensus	ndWTATGCTAATTARbn
GC content	30.99%
Information content (bits; total / per base)	18.227 / 1.072
Data sources	Methyl-HT-SELEX
Aligned words	3778

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	6 (39)	0.608	0.794	0.418	0.648	0.549	0.772	1.5	2.269	4.481	59.398

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.979	0.972	0.923	0.91	0.835	0.816
Overall, 4 experiments	best	0.998	0.997	0.982	0.977	0.934	0.923
Methyl HT-SELEX, 1 experiments	median	0.998	0.997	0.982	0.977	0.934	0.923
Methyl HT-SELEX, 1 experiments	best	0.998	0.997	0.982	0.977	0.934	0.923
Non-Methyl HT-SELEX, 3 experiments	median	0.962	0.95	0.877	0.858	0.796	0.764
Non-Methyl HT-SELEX, 3 experiments	best	0.996	0.994	0.969	0.962	0.873	0.868

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	POU {3.1.10} (TFClass)
TF subfamily	POU3 {3.1.10.3} (TFClass)
TFClass ID	TFClass: 3.1.10.3.1
HGNC	HGNC:9214
MGI	MGI:101896
EntrezGene (human)	GeneID:5453 (SSTAR profile)
EntrezGene (mouse)	GeneID:18991 (SSTAR profile)
UniProt ID (human)	PO3F1_HUMAN
UniProt ID (mouse)	PO3F1_MOUSE
UniProt AC (human)	Q03052 (TFClass)
UniProt AC (mouse)	P21952 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 6 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	PO3F1.H12RSNP.3.M.D.pcm
PWM	PO3F1.H12RSNP.3.M.D.pwm
PFM	PO3F1.H12RSNP.3.M.D.pfm
Alignment	PO3F1.H12RSNP.3.M.D.words.tsv
Threshold to P-value map	PO3F1.H12RSNP.3.M.D.thr
Motif in other formats
JASPAR format	PO3F1.H12RSNP.3.M.D_jaspar_format.txt
MEME format	PO3F1.H12RSNP.3.M.D_meme_format.meme
Transfac format	PO3F1.H12RSNP.3.M.D_transfac_format.txt
Homer format	PO3F1.H12RSNP.3.M.D_homer_format_0.001.txt PO3F1.H12RSNP.3.M.D_homer_format_0.0005.txt PO3F1.H12RSNP.3.M.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1235.25	979.25	934.25	629.25
02	1818.25	548.25	731.25	680.25
03	632.0	114.0	573.0	2459.0
04	194.0	264.0	69.0	3251.0
05	3442.0	57.0	222.0	57.0
06	34.0	226.0	172.0	3346.0
07	225.0	159.0	3390.0	4.0
08	155.0	3063.0	97.0	463.0
09	770.0	0.0	3.0	3005.0
10	3778.0	0.0	0.0	0.0
11	3778.0	0.0	0.0	0.0
12	0.0	0.0	0.0	3778.0
13	3.0	14.0	1110.0	2651.0
14	3646.0	39.0	29.0	64.0
15	567.0	378.0	2638.0	195.0
16	473.0	1032.0	1411.0	862.0
17	661.0	902.0	750.0	1465.0

PFM

	A	C	G	T
01	0.327	0.259	0.247	0.167
02	0.481	0.145	0.194	0.18
03	0.167	0.03	0.152	0.651
04	0.051	0.07	0.018	0.861
05	0.911	0.015	0.059	0.015
06	0.009	0.06	0.046	0.886
07	0.06	0.042	0.897	0.001
08	0.041	0.811	0.026	0.123
09	0.204	0.0	0.001	0.795
10	1.0	0.0	0.0	0.0
11	1.0	0.0	0.0	0.0
12	0.0	0.0	0.0	1.0
13	0.001	0.004	0.294	0.702
14	0.965	0.01	0.008	0.017
15	0.15	0.1	0.698	0.052
16	0.125	0.273	0.373	0.228
17	0.175	0.239	0.199	0.388

PWM

	A	C	G	T
01	0.268	0.036	-0.011	-0.405
02	0.654	-0.542	-0.255	-0.327
03	-0.401	-2.099	-0.498	0.956
04	-1.574	-1.269	-2.589	1.235
05	1.292	-2.774	-1.441	-2.774
06	-3.268	-1.423	-1.693	1.263
07	-1.428	-1.771	1.276	-5.051
08	-1.796	1.175	-2.257	-0.711
09	-0.204	-6.13	-5.232	1.156
10	1.385	-6.13	-6.13	-6.13
11	1.385	-6.13	-6.13	-6.13
12	-6.13	-6.13	-6.13	1.385
13	-5.232	-4.077	0.161	1.031
14	1.349	-3.138	-3.417	-2.662
15	-0.509	-0.913	1.026	-1.569
16	-0.689	0.088	0.401	-0.091
17	-0.356	-0.046	-0.23	0.438

Standard thresholds

P-value	Threshold
0.001	0.07531
0.0005	1.71436
0.0001	5.07316