PO3F1.H12INVIVO.1.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	PO3F1.H12INVIVO.1.PS.A
Gene (human)	POU3F1 (GeneCards)
Gene synonyms (human)	OCT6, OTF6
Gene (mouse)	Pou3f1
Gene synonyms (mouse)	Oct6, Otf-6, Otf6, Scip
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	15
Consensus	dhhYATGMATAWKSM
GC content	31.86%
Information content (bits; total / per base)	15.371 / 1.025
Data sources	ChIP-Seq + HT-SELEX
Aligned words	868

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	6 (39)	0.747	0.964	0.63	0.952	0.765	0.957	2.337	6.354	78.337	357.201

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.947	0.921	0.903	0.87	0.816	0.791
Overall, 4 experiments	best	0.997	0.995	0.985	0.981	0.933	0.924
Methyl HT-SELEX, 1 experiments	median	0.915	0.873	0.879	0.83	0.831	0.782
Methyl HT-SELEX, 1 experiments	best	0.915	0.873	0.879	0.83	0.831	0.782
Non-Methyl HT-SELEX, 3 experiments	median	0.979	0.97	0.928	0.91	0.801	0.8
Non-Methyl HT-SELEX, 3 experiments	best	0.997	0.995	0.985	0.981	0.933	0.924

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	POU {3.1.10} (TFClass)
TF subfamily	POU3 {3.1.10.3} (TFClass)
TFClass ID	TFClass: 3.1.10.3.1
HGNC	HGNC:9214
MGI	MGI:101896
EntrezGene (human)	GeneID:5453 (SSTAR profile)
EntrezGene (mouse)	GeneID:18991 (SSTAR profile)
UniProt ID (human)	PO3F1_HUMAN
UniProt ID (mouse)	PO3F1_MOUSE
UniProt AC (human)	Q03052 (TFClass)
UniProt AC (mouse)	P21952 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 6 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	PO3F1.H12INVIVO.1.PS.A.pcm
PWM	PO3F1.H12INVIVO.1.PS.A.pwm
PFM	PO3F1.H12INVIVO.1.PS.A.pfm
Alignment	PO3F1.H12INVIVO.1.PS.A.words.tsv
Threshold to P-value map	PO3F1.H12INVIVO.1.PS.A.thr
Motif in other formats
JASPAR format	PO3F1.H12INVIVO.1.PS.A_jaspar_format.txt
MEME format	PO3F1.H12INVIVO.1.PS.A_meme_format.meme
Transfac format	PO3F1.H12INVIVO.1.PS.A_transfac_format.txt
Homer format	PO3F1.H12INVIVO.1.PS.A_homer_format_0.001.txt PO3F1.H12INVIVO.1.PS.A_homer_format_0.0005.txt PO3F1.H12INVIVO.1.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	299.0	120.0	171.0	278.0
02	98.0	474.0	75.0	221.0
03	281.0	89.0	68.0	430.0
04	89.0	662.0	10.0	107.0
05	828.0	4.0	6.0	30.0
06	6.0	2.0	3.0	857.0
07	88.0	5.0	765.0	10.0
08	492.0	360.0	5.0	11.0
09	852.0	6.0	3.0	7.0
10	27.0	4.0	1.0	836.0
11	797.0	8.0	8.0	55.0
12	385.0	14.0	7.0	462.0
13	87.0	10.0	247.0	524.0
14	7.0	386.0	290.0	185.0
15	513.0	325.0	20.0	10.0

PFM

	A	C	G	T
01	0.344	0.138	0.197	0.32
02	0.113	0.546	0.086	0.255
03	0.324	0.103	0.078	0.495
04	0.103	0.763	0.012	0.123
05	0.954	0.005	0.007	0.035
06	0.007	0.002	0.003	0.987
07	0.101	0.006	0.881	0.012
08	0.567	0.415	0.006	0.013
09	0.982	0.007	0.003	0.008
10	0.031	0.005	0.001	0.963
11	0.918	0.009	0.009	0.063
12	0.444	0.016	0.008	0.532
13	0.1	0.012	0.285	0.604
14	0.008	0.445	0.334	0.213
15	0.591	0.374	0.023	0.012

PWM

	A	C	G	T
01	0.318	-0.586	-0.236	0.246
02	-0.786	0.777	-1.048	0.018
03	0.257	-0.88	-1.144	0.68
04	-0.88	1.11	-2.929	-0.699
05	1.333	-3.649	-3.348	-1.932
06	-3.348	-4.082	-3.842	1.368
07	-0.891	-3.487	1.254	-2.929
08	0.814	0.503	-3.487	-2.847
09	1.362	-3.348	-3.842	-3.225
10	-2.031	-3.649	-4.398	1.343
11	1.295	-3.116	-3.116	-1.35
12	0.57	-2.635	-3.225	0.752
13	-0.902	-2.929	0.129	0.877
14	-3.225	0.573	0.288	-0.158
15	0.856	0.401	-2.311	-2.929

Standard thresholds

P-value	Threshold
0.001	2.55031
0.0005	3.80046
0.0001	6.42476