| Motif | PITX3.H12INVIVO.0.SM.D |
| Gene (human) | PITX3 (GeneCards) |
| Gene synonyms (human) | PTX3 |
| Gene (mouse) | Pitx3 |
| Gene synonyms (mouse) | |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | D |
| Motif | PITX3.H12INVIVO.0.SM.D |
| Gene (human) | PITX3 (GeneCards) |
| Gene synonyms (human) | PTX3 |
| Gene (mouse) | Pitx3 |
| Gene synonyms (mouse) | |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | D |
| Motif length | 9 |
| Consensus | nGGATTAvn |
| GC content | 40.05% |
| Information content (bits; total / per base) | 10.877 / 1.209 |
| Data sources | HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 9481 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 6 experiments | median | 0.979 | 0.964 | 0.971 | 0.953 | 0.926 | 0.908 |
| best | 0.992 | 0.988 | 0.988 | 0.981 | 0.966 | 0.946 | |
| Methyl HT-SELEX, 2 experiments | median | 0.971 | 0.952 | 0.965 | 0.942 | 0.944 | 0.918 |
| best | 0.979 | 0.962 | 0.976 | 0.957 | 0.966 | 0.945 | |
| Non-Methyl HT-SELEX, 4 experiments | median | 0.981 | 0.968 | 0.971 | 0.955 | 0.899 | 0.888 |
| best | 0.992 | 0.988 | 0.988 | 0.981 | 0.966 | 0.946 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 2 | 0.617 | 0.292 | 0.627 | 0.423 |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Homeo domain factors {3.1} (TFClass) |
| TF family | Paired-related HD {3.1.3} (TFClass) |
| TF subfamily | PITX {3.1.3.19} (TFClass) |
| TFClass ID | TFClass: 3.1.3.19.3 |
| HGNC | HGNC:9006 |
| MGI | MGI:1100498 |
| EntrezGene (human) | GeneID:5309 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:18742 (SSTAR profile) |
| UniProt ID (human) | PITX3_HUMAN |
| UniProt ID (mouse) | PITX3_MOUSE |
| UniProt AC (human) | O75364 (TFClass) |
| UniProt AC (mouse) | O35160 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 0 human, 0 mouse |
| HT-SELEX | 4 |
| Methyl-HT-SELEX | 2 |
| PCM | PITX3.H12INVIVO.0.SM.D.pcm |
| PWM | PITX3.H12INVIVO.0.SM.D.pwm |
| PFM | PITX3.H12INVIVO.0.SM.D.pfm |
| Alignment | PITX3.H12INVIVO.0.SM.D.words.tsv |
| Threshold to P-value map | PITX3.H12INVIVO.0.SM.D.thr |
| Motif in other formats | |
| JASPAR format | PITX3.H12INVIVO.0.SM.D_jaspar_format.txt |
| MEME format | PITX3.H12INVIVO.0.SM.D_meme_format.meme |
| Transfac format | PITX3.H12INVIVO.0.SM.D_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 2094.25 | 2353.25 | 2608.25 | 2425.25 |
| 02 | 652.0 | 57.0 | 8414.0 | 358.0 |
| 03 | 1.0 | 26.0 | 9454.0 | 0.0 |
| 04 | 8237.0 | 1244.0 | 0.0 | 0.0 |
| 05 | 0.0 | 0.0 | 0.0 | 9481.0 |
| 06 | 0.0 | 272.0 | 0.0 | 9209.0 |
| 07 | 9395.0 | 3.0 | 7.0 | 76.0 |
| 08 | 4942.0 | 1189.0 | 2441.0 | 909.0 |
| 09 | 1509.5 | 2851.5 | 3251.5 | 1868.5 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.221 | 0.248 | 0.275 | 0.256 |
| 02 | 0.069 | 0.006 | 0.887 | 0.038 |
| 03 | 0.0 | 0.003 | 0.997 | 0.0 |
| 04 | 0.869 | 0.131 | 0.0 | 0.0 |
| 05 | 0.0 | 0.0 | 0.0 | 1.0 |
| 06 | 0.0 | 0.029 | 0.0 | 0.971 |
| 07 | 0.991 | 0.0 | 0.001 | 0.008 |
| 08 | 0.521 | 0.125 | 0.257 | 0.096 |
| 09 | 0.159 | 0.301 | 0.343 | 0.197 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.124 | -0.007 | 0.096 | 0.023 |
| 02 | -1.288 | -3.689 | 1.266 | -1.885 |
| 03 | -6.581 | -4.429 | 1.383 | -6.943 |
| 04 | 1.245 | -0.644 | -6.943 | -6.943 |
| 05 | -6.943 | -6.943 | -6.943 | 1.386 |
| 06 | -6.943 | -2.158 | -6.943 | 1.356 |
| 07 | 1.376 | -6.106 | -5.543 | -3.411 |
| 08 | 0.734 | -0.689 | 0.029 | -0.957 |
| 09 | -0.451 | 0.185 | 0.316 | -0.238 |
| P-value | Threshold |
|---|---|
| 0.001 | 4.25473 |
| 0.0005 | 5.631135 |
| 0.0001 | 7.77096 |