MotifPITX3.H12INVITRO.1.S.B
Gene (human)PITX3
(GeneCards)
Gene synonyms (human)PTX3
Gene (mouse)Pitx3
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
B
Motif length20
ConsensusvvdddWWhvnbGGATTAvbb
GC content43.28%
Information content (bits; total / per base)14.165 / 0.708
Data sourcesHT-SELEX
Aligned words446

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 6 experiments median 0.976 0.959 0.955 0.928 0.872 0.86
best 0.994 0.991 0.977 0.97 0.943 0.918
Methyl HT-SELEX, 2 experiments median 0.97 0.948 0.956 0.93 0.921 0.892
best 0.977 0.96 0.968 0.947 0.943 0.918
Non-Methyl HT-SELEX, 4 experiments median 0.976 0.961 0.934 0.916 0.831 0.821
best 0.994 0.991 0.977 0.97 0.935 0.909

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.651 0.275 0.591 0.376
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyPaired-related HD {3.1.3} (TFClass)
TF subfamilyPITX {3.1.3.19} (TFClass)
TFClass IDTFClass: 3.1.3.19.3
HGNCHGNC:9006
MGIMGI:1100498
EntrezGene (human)GeneID:5309
(SSTAR profile)
EntrezGene (mouse)GeneID:18742
(SSTAR profile)
UniProt ID (human)PITX3_HUMAN
UniProt ID (mouse)PITX3_MOUSE
UniProt AC (human)O75364
(TFClass)
UniProt AC (mouse)O35160
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 0 human, 0 mouse
HT-SELEX 4
Methyl-HT-SELEX 2
PCM
ACGT
0181.5122.5177.564.5
0285.25101.25195.2564.25
0386.061.0218.081.0
04142.020.0170.0114.0
05147.015.0122.0162.0
06215.026.023.0182.0
07162.048.020.0216.0
08139.081.045.0181.0
09181.0106.092.067.0
10149.0103.0113.081.0
1150.0105.0208.083.0
1211.09.0419.07.0
131.01.0444.00.0
14429.017.00.00.0
150.00.00.0446.0
160.02.01.0443.0
17440.02.00.04.0
18203.044.0166.033.0
1942.585.5201.5116.5
2072.091.0205.078.0
PFM
ACGT
010.1830.2750.3980.145
020.1910.2270.4380.144
030.1930.1370.4890.182
040.3180.0450.3810.256
050.330.0340.2740.363
060.4820.0580.0520.408
070.3630.1080.0450.484
080.3120.1820.1010.406
090.4060.2380.2060.15
100.3340.2310.2530.182
110.1120.2350.4660.186
120.0250.020.9390.016
130.0020.0020.9960.0
140.9620.0380.00.0
150.00.00.01.0
160.00.0040.0020.993
170.9870.0040.00.009
180.4550.0990.3720.074
190.0950.1920.4520.261
200.1610.2040.460.175
PWM
ACGT
01-0.3080.0930.46-0.538
02-0.264-0.0950.554-0.541
03-0.256-0.5920.664-0.315
040.239-1.6580.4170.022
050.273-1.9230.0890.369
060.65-1.413-1.5280.485
070.369-0.825-1.6580.655
080.218-0.315-0.8880.479
090.479-0.05-0.189-0.5
100.287-0.0780.013-0.315
11-0.786-0.0590.617-0.291
12-2.2-2.3741.314-2.585
13-3.801-3.8011.372-4.306
141.337-1.808-4.306-4.306
15-4.306-4.306-4.3061.376
16-4.306-3.468-3.8011.369
171.363-3.468-4.306-3.018
180.593-0.9090.394-1.186
19-0.943-0.2610.5860.043
20-0.43-0.20.603-0.352
Standard thresholds
P-value Threshold
0.001 3.16231
0.0005 4.36321
0.0001 6.87746