| Motif | PITX3.H12INVITRO.0.SM.B |
| Gene (human) | PITX3 (GeneCards) |
| Gene synonyms (human) | PTX3 |
| Gene (mouse) | Pitx3 |
| Gene synonyms (mouse) | |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | B |
| Motif | PITX3.H12INVITRO.0.SM.B |
| Gene (human) | PITX3 (GeneCards) |
| Gene synonyms (human) | PTX3 |
| Gene (mouse) | Pitx3 |
| Gene synonyms (mouse) | |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | B |
| Motif length | 10 |
| Consensus | nGGATTAvbn |
| GC content | 42.38% |
| Information content (bits; total / per base) | 11.101 / 1.11 |
| Data sources | HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 8101 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 6 experiments | median | 0.983 | 0.969 | 0.97 | 0.954 | 0.915 | 0.899 |
| best | 0.993 | 0.987 | 0.988 | 0.981 | 0.964 | 0.946 | |
| Methyl HT-SELEX, 2 experiments | median | 0.975 | 0.956 | 0.966 | 0.944 | 0.936 | 0.912 |
| best | 0.982 | 0.968 | 0.978 | 0.962 | 0.963 | 0.944 | |
| Non-Methyl HT-SELEX, 4 experiments | median | 0.984 | 0.971 | 0.97 | 0.955 | 0.885 | 0.879 |
| best | 0.993 | 0.987 | 0.988 | 0.981 | 0.964 | 0.946 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 2 | 0.63 | 0.287 | 0.61 | 0.41 |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Homeo domain factors {3.1} (TFClass) |
| TF family | Paired-related HD {3.1.3} (TFClass) |
| TF subfamily | PITX {3.1.3.19} (TFClass) |
| TFClass ID | TFClass: 3.1.3.19.3 |
| HGNC | HGNC:9006 |
| MGI | MGI:1100498 |
| EntrezGene (human) | GeneID:5309 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:18742 (SSTAR profile) |
| UniProt ID (human) | PITX3_HUMAN |
| UniProt ID (mouse) | PITX3_MOUSE |
| UniProt AC (human) | O75364 (TFClass) |
| UniProt AC (mouse) | O35160 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 0 human, 0 mouse |
| HT-SELEX | 4 |
| Methyl-HT-SELEX | 2 |
| PCM | PITX3.H12INVITRO.0.SM.B.pcm |
| PWM | PITX3.H12INVITRO.0.SM.B.pwm |
| PFM | PITX3.H12INVITRO.0.SM.B.pfm |
| Alignment | PITX3.H12INVITRO.0.SM.B.words.tsv |
| Threshold to P-value map | PITX3.H12INVITRO.0.SM.B.thr |
| Motif in other formats | |
| JASPAR format | PITX3.H12INVITRO.0.SM.B_jaspar_format.txt |
| MEME format | PITX3.H12INVITRO.0.SM.B_meme_format.meme |
| Transfac format | PITX3.H12INVITRO.0.SM.B_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 1471.25 | 1785.25 | 3123.25 | 1721.25 |
| 02 | 734.0 | 330.0 | 6623.0 | 414.0 |
| 03 | 0.0 | 0.0 | 8101.0 | 0.0 |
| 04 | 7769.0 | 332.0 | 0.0 | 0.0 |
| 05 | 0.0 | 0.0 | 0.0 | 8101.0 |
| 06 | 0.0 | 0.0 | 0.0 | 8101.0 |
| 07 | 7951.0 | 4.0 | 22.0 | 124.0 |
| 08 | 3459.0 | 1040.0 | 2599.0 | 1003.0 |
| 09 | 873.75 | 2357.75 | 3261.75 | 1607.75 |
| 10 | 1411.5 | 1895.5 | 2859.5 | 1934.5 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.182 | 0.22 | 0.386 | 0.212 |
| 02 | 0.091 | 0.041 | 0.818 | 0.051 |
| 03 | 0.0 | 0.0 | 1.0 | 0.0 |
| 04 | 0.959 | 0.041 | 0.0 | 0.0 |
| 05 | 0.0 | 0.0 | 0.0 | 1.0 |
| 06 | 0.0 | 0.0 | 0.0 | 1.0 |
| 07 | 0.981 | 0.0 | 0.003 | 0.015 |
| 08 | 0.427 | 0.128 | 0.321 | 0.124 |
| 09 | 0.108 | 0.291 | 0.403 | 0.198 |
| 10 | 0.174 | 0.234 | 0.353 | 0.239 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.319 | -0.126 | 0.433 | -0.162 |
| 02 | -1.013 | -1.809 | 1.184 | -1.583 |
| 03 | -6.804 | -6.804 | 1.385 | -6.804 |
| 04 | 1.344 | -1.803 | -6.804 | -6.804 |
| 05 | -6.804 | -6.804 | -6.804 | 1.385 |
| 06 | -6.804 | -6.804 | -6.804 | 1.385 |
| 07 | 1.367 | -5.782 | -4.426 | -2.776 |
| 08 | 0.535 | -0.665 | 0.249 | -0.702 |
| 09 | -0.839 | 0.152 | 0.476 | -0.231 |
| 10 | -0.361 | -0.066 | 0.345 | -0.046 |
| P-value | Threshold |
|---|---|
| 0.001 | 4.38131 |
| 0.0005 | 5.535275 |
| 0.0001 | 7.902575 |