MotifPITX2.H12INVIVO.0.SM.D
Gene (human)PITX2
(GeneCards)
Gene synonyms (human)ARP1, RGS, RIEG, RIEG1
Gene (mouse)Pitx2
Gene synonyms (mouse)Arp1, Brx1, Otlx2, Ptx2, Rgs
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
D
Motif length10
ConsensusnRGATTAvbn
GC content41.96%
Information content (bits; total / per base)9.981 / 0.998
Data sourcesHT-SELEX + Methyl-HT-SELEX
Aligned words8721

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 6 experiments median 0.963 0.941 0.949 0.92 0.921 0.892
best 0.995 0.992 0.993 0.988 0.988 0.982
Methyl HT-SELEX, 3 experiments median 0.987 0.978 0.982 0.97 0.975 0.959
best 0.995 0.992 0.993 0.988 0.988 0.982
Non-Methyl HT-SELEX, 3 experiments median 0.937 0.894 0.916 0.87 0.875 0.829
best 0.99 0.984 0.986 0.976 0.967 0.956

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.891 0.659 0.874 0.658
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyPaired-related HD {3.1.3} (TFClass)
TF subfamilyPITX {3.1.3.19} (TFClass)
TFClass IDTFClass: 3.1.3.19.2
HGNCHGNC:9005
MGIMGI:109340
EntrezGene (human)GeneID:5308
(SSTAR profile)
EntrezGene (mouse)GeneID:18741
(SSTAR profile)
UniProt ID (human)PITX2_HUMAN
UniProt ID (mouse)PITX2_MOUSE
UniProt AC (human)Q99697
(TFClass)
UniProt AC (mouse)P97474
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 0 human, 0 mouse
HT-SELEX 3
Methyl-HT-SELEX 3
PCM
ACGT
012003.51865.52981.51870.5
02838.25471.256794.25617.25
0333.0178.08487.023.0
047751.0960.010.00.0
050.00.00.08721.0
060.0312.05.08404.0
078395.077.077.0172.0
083773.01354.02479.01115.0
091122.252721.253046.251831.25
101812.251834.252944.252130.25
PFM
ACGT
010.230.2140.3420.214
020.0960.0540.7790.071
030.0040.020.9730.003
040.8890.110.0010.0
050.00.00.01.0
060.00.0360.0010.964
070.9630.0090.0090.02
080.4330.1550.2840.128
090.1290.3120.3490.21
100.2080.210.3380.244
PWM
ACGT
01-0.084-0.1560.313-0.153
02-0.954-1.5281.136-1.259
03-4.125-2.4941.358-4.459
041.268-0.819-5.181-6.869
05-6.869-6.869-6.8691.386
06-6.869-1.938-5.7051.348
071.347-3.315-3.315-2.528
080.548-0.4760.128-0.67
09-0.6630.2210.334-0.174
10-0.185-0.1730.3-0.023
Standard thresholds
P-value Threshold
0.001 4.93548
0.0005 5.79453
0.0001 7.837215