| Motif | PITX2.H12INVITRO.0.SM.B |
| Gene (human) | PITX2 (GeneCards) |
| Gene synonyms (human) | ARP1, RGS, RIEG, RIEG1 |
| Gene (mouse) | Pitx2 |
| Gene synonyms (mouse) | Arp1, Brx1, Otlx2, Ptx2, Rgs |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | B |
| Motif | PITX2.H12INVITRO.0.SM.B |
| Gene (human) | PITX2 (GeneCards) |
| Gene synonyms (human) | ARP1, RGS, RIEG, RIEG1 |
| Gene (mouse) | Pitx2 |
| Gene synonyms (mouse) | Arp1, Brx1, Otlx2, Ptx2, Rgs |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | B |
| Motif length | 10 |
| Consensus | nRGATTAvbn |
| GC content | 41.96% |
| Information content (bits; total / per base) | 9.981 / 0.998 |
| Data sources | HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 8721 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 6 experiments | median | 0.963 | 0.941 | 0.949 | 0.92 | 0.921 | 0.892 |
| best | 0.995 | 0.992 | 0.993 | 0.988 | 0.988 | 0.982 | |
| Methyl HT-SELEX, 3 experiments | median | 0.987 | 0.978 | 0.982 | 0.97 | 0.975 | 0.959 |
| best | 0.995 | 0.992 | 0.993 | 0.988 | 0.988 | 0.982 | |
| Non-Methyl HT-SELEX, 3 experiments | median | 0.937 | 0.894 | 0.916 | 0.87 | 0.875 | 0.829 |
| best | 0.99 | 0.984 | 0.986 | 0.976 | 0.967 | 0.956 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 2 | 0.891 | 0.659 | 0.874 | 0.658 |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Homeo domain factors {3.1} (TFClass) |
| TF family | Paired-related HD {3.1.3} (TFClass) |
| TF subfamily | PITX {3.1.3.19} (TFClass) |
| TFClass ID | TFClass: 3.1.3.19.2 |
| HGNC | HGNC:9005 |
| MGI | MGI:109340 |
| EntrezGene (human) | GeneID:5308 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:18741 (SSTAR profile) |
| UniProt ID (human) | PITX2_HUMAN |
| UniProt ID (mouse) | PITX2_MOUSE |
| UniProt AC (human) | Q99697 (TFClass) |
| UniProt AC (mouse) | P97474 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 0 human, 0 mouse |
| HT-SELEX | 3 |
| Methyl-HT-SELEX | 3 |
| PCM | PITX2.H12INVITRO.0.SM.B.pcm |
| PWM | PITX2.H12INVITRO.0.SM.B.pwm |
| PFM | PITX2.H12INVITRO.0.SM.B.pfm |
| Alignment | PITX2.H12INVITRO.0.SM.B.words.tsv |
| Threshold to P-value map | PITX2.H12INVITRO.0.SM.B.thr |
| Motif in other formats | |
| JASPAR format | PITX2.H12INVITRO.0.SM.B_jaspar_format.txt |
| MEME format | PITX2.H12INVITRO.0.SM.B_meme_format.meme |
| Transfac format | PITX2.H12INVITRO.0.SM.B_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 2003.5 | 1865.5 | 2981.5 | 1870.5 |
| 02 | 838.25 | 471.25 | 6794.25 | 617.25 |
| 03 | 33.0 | 178.0 | 8487.0 | 23.0 |
| 04 | 7751.0 | 960.0 | 10.0 | 0.0 |
| 05 | 0.0 | 0.0 | 0.0 | 8721.0 |
| 06 | 0.0 | 312.0 | 5.0 | 8404.0 |
| 07 | 8395.0 | 77.0 | 77.0 | 172.0 |
| 08 | 3773.0 | 1354.0 | 2479.0 | 1115.0 |
| 09 | 1122.25 | 2721.25 | 3046.25 | 1831.25 |
| 10 | 1812.25 | 1834.25 | 2944.25 | 2130.25 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.23 | 0.214 | 0.342 | 0.214 |
| 02 | 0.096 | 0.054 | 0.779 | 0.071 |
| 03 | 0.004 | 0.02 | 0.973 | 0.003 |
| 04 | 0.889 | 0.11 | 0.001 | 0.0 |
| 05 | 0.0 | 0.0 | 0.0 | 1.0 |
| 06 | 0.0 | 0.036 | 0.001 | 0.964 |
| 07 | 0.963 | 0.009 | 0.009 | 0.02 |
| 08 | 0.433 | 0.155 | 0.284 | 0.128 |
| 09 | 0.129 | 0.312 | 0.349 | 0.21 |
| 10 | 0.208 | 0.21 | 0.338 | 0.244 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.084 | -0.156 | 0.313 | -0.153 |
| 02 | -0.954 | -1.528 | 1.136 | -1.259 |
| 03 | -4.125 | -2.494 | 1.358 | -4.459 |
| 04 | 1.268 | -0.819 | -5.181 | -6.869 |
| 05 | -6.869 | -6.869 | -6.869 | 1.386 |
| 06 | -6.869 | -1.938 | -5.705 | 1.348 |
| 07 | 1.347 | -3.315 | -3.315 | -2.528 |
| 08 | 0.548 | -0.476 | 0.128 | -0.67 |
| 09 | -0.663 | 0.221 | 0.334 | -0.174 |
| 10 | -0.185 | -0.173 | 0.3 | -0.023 |
| P-value | Threshold |
|---|---|
| 0.001 | 4.93548 |
| 0.0005 | 5.79453 |
| 0.0001 | 7.837215 |