MotifPITX1.H12CORE.1.S.B
Gene (human)PITX1
(GeneCards)
Gene synonyms (human)BFT, PTX1
Gene (mouse)Pitx1
Gene synonyms (mouse)Bft, Potx, Ptx1
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
B
Motif length20
ConsensusvnGGATTAAndKdKWWhhnn
GC content36.31%
Information content (bits; total / per base)15.927 / 0.796
Data sourcesHT-SELEX
Aligned words1787

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 1 (2) 0.656 0.657 0.493 0.496 0.67 0.671 1.906 1.91 0.0 0
Mouse 4 (24) 0.694 0.751 0.54 0.593 0.702 0.782 2.048 2.485 50.654 103.886

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 10 experiments median 0.918 0.894 0.805 0.8 0.671 0.689
best 0.971 0.964 0.952 0.924 0.911 0.881
Methyl HT-SELEX, 2 experiments median 0.946 0.913 0.923 0.885 0.877 0.839
best 0.968 0.946 0.952 0.924 0.911 0.881
Non-Methyl HT-SELEX, 8 experiments median 0.909 0.894 0.755 0.753 0.636 0.655
best 0.971 0.964 0.922 0.884 0.871 0.833

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.784 0.6 0.783 0.603
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyPaired-related HD {3.1.3} (TFClass)
TF subfamilyPITX {3.1.3.19} (TFClass)
TFClass IDTFClass: 3.1.3.19.1
HGNCHGNC:9004
MGIMGI:107374
EntrezGene (human)GeneID:5307
(SSTAR profile)
EntrezGene (mouse)GeneID:18740
(SSTAR profile)
UniProt ID (human)PITX1_HUMAN
UniProt ID (mouse)PITX1_MOUSE
UniProt AC (human)P78337
(TFClass)
UniProt AC (mouse)P70314
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 1 human, 4 mouse
HT-SELEX 8
Methyl-HT-SELEX 2
PCM
ACGT
01741.0266.0534.0246.0
02523.75295.75527.75439.75
03138.06.01561.082.0
0474.01.01712.00.0
051773.014.00.00.0
060.00.00.01787.0
070.070.00.01717.0
081717.070.00.00.0
091626.030.0109.022.0
10324.0466.0606.0391.0
11318.0223.0977.0269.0
12195.0195.01167.0230.0
13836.079.0609.0263.0
14430.020.0443.0894.0
15476.016.0137.01158.0
161012.040.016.0719.0
17893.0186.0147.0561.0
18654.0444.0193.0496.0
19502.25593.25261.25430.25
20360.0660.0302.0465.0
PFM
ACGT
010.4150.1490.2990.138
020.2930.1660.2950.246
030.0770.0030.8740.046
040.0410.0010.9580.0
050.9920.0080.00.0
060.00.00.01.0
070.00.0390.00.961
080.9610.0390.00.0
090.910.0170.0610.012
100.1810.2610.3390.219
110.1780.1250.5470.151
120.1090.1090.6530.129
130.4680.0440.3410.147
140.2410.0110.2480.5
150.2660.0090.0770.648
160.5660.0220.0090.402
170.50.1040.0820.314
180.3660.2480.1080.278
190.2810.3320.1460.241
200.2010.3690.1690.26
PWM
ACGT
010.504-0.5160.178-0.593
020.158-0.410.166-0.016
03-1.165-4.0431.248-1.677
04-1.777-5.0511.34-5.479
051.375-3.342-5.479-5.479
06-5.479-5.479-5.4791.383
07-5.479-1.831-5.4791.343
081.343-1.831-5.479-5.479
091.289-2.644-1.398-2.933
10-0.320.0420.304-0.133
11-0.338-0.6910.78-0.505
12-0.824-0.8240.958-0.66
130.625-1.7130.309-0.527
14-0.038-3.021-0.0080.692
150.063-3.223-1.1730.95
160.815-2.372-3.2230.474
170.69-0.87-1.1030.227
180.38-0.006-0.8340.104
190.1170.283-0.534-0.037
20-0.2150.389-0.390.04
Standard thresholds
P-value Threshold
0.001 1.85376
0.0005 3.27891
0.0001 6.19246