PIT1.H12INVIVO.0.SM.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	PIT1.H12INVIVO.0.SM.D
Gene (human)	POU1F1 (GeneCards)
Gene synonyms (human)	GHF1, PIT1
Gene (mouse)	Pou1f1
Gene synonyms (mouse)	Pit-1, Pit1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	D

Motif length	14
Consensus	nhTAATGAGATGCR
GC content	36.13%
Information content (bits; total / per base)	19.235 / 1.374
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	5039

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.998	0.998	0.971	0.966	0.897	0.887
Overall, 3 experiments	best	1.0	1.0	0.997	0.997	0.957	0.954
Methyl HT-SELEX, 1 experiments	median	1.0	1.0	0.997	0.997	0.957	0.954
Methyl HT-SELEX, 1 experiments	best	1.0	1.0	0.997	0.997	0.957	0.954
Non-Methyl HT-SELEX, 2 experiments	median	0.924	0.903	0.869	0.847	0.791	0.775
Non-Methyl HT-SELEX, 2 experiments	best	0.998	0.998	0.971	0.966	0.897	0.887

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	POU {3.1.10} (TFClass)
TF subfamily	POU1 {3.1.10.1} (TFClass)
TFClass ID	TFClass: 3.1.10.1.1
HGNC	HGNC:9210
MGI	MGI:97588
EntrezGene (human)	GeneID:5449 (SSTAR profile)
EntrezGene (mouse)	GeneID:18736 (SSTAR profile)
UniProt ID (human)	PIT1_HUMAN
UniProt ID (mouse)	PIT1_MOUSE
UniProt AC (human)	P28069 (TFClass)
UniProt AC (mouse)	Q00286 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	2
Methyl-HT-SELEX	1

PCM	PIT1.H12INVIVO.0.SM.D.pcm
PWM	PIT1.H12INVIVO.0.SM.D.pwm
PFM	PIT1.H12INVIVO.0.SM.D.pfm
Alignment	PIT1.H12INVIVO.0.SM.D.words.tsv
Threshold to P-value map	PIT1.H12INVIVO.0.SM.D.thr
Motif in other formats
JASPAR format	PIT1.H12INVIVO.0.SM.D_jaspar_format.txt
MEME format	PIT1.H12INVIVO.0.SM.D_meme_format.meme
Transfac format	PIT1.H12INVIVO.0.SM.D_transfac_format.txt
Homer format	PIT1.H12INVIVO.0.SM.D_homer_format_0.001.txt PIT1.H12INVIVO.0.SM.D_homer_format_0.0005.txt PIT1.H12INVIVO.0.SM.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1491.75	1100.75	1749.75	696.75
02	797.75	815.75	674.75	2750.75
03	75.0	26.0	9.0	4929.0
04	5026.0	7.0	5.0	1.0
05	5039.0	0.0	0.0	0.0
06	0.0	4.0	4.0	5031.0
07	4.0	3.0	4052.0	980.0
08	5025.0	1.0	4.0	9.0
09	59.0	96.0	4300.0	584.0
10	4809.0	51.0	111.0	68.0
11	76.0	73.0	43.0	4847.0
12	122.0	76.0	4279.0	562.0
13	131.25	4686.25	106.25	115.25
14	1461.0	353.0	2855.0	370.0

PFM

	A	C	G	T
01	0.296	0.218	0.347	0.138
02	0.158	0.162	0.134	0.546
03	0.015	0.005	0.002	0.978
04	0.997	0.001	0.001	0.0
05	1.0	0.0	0.0	0.0
06	0.0	0.001	0.001	0.998
07	0.001	0.001	0.804	0.194
08	0.997	0.0	0.001	0.002
09	0.012	0.019	0.853	0.116
10	0.954	0.01	0.022	0.013
11	0.015	0.014	0.009	0.962
12	0.024	0.015	0.849	0.112
13	0.026	0.93	0.021	0.023
14	0.29	0.07	0.567	0.073

PWM

	A	C	G	T
01	0.169	-0.135	0.328	-0.591
02	-0.456	-0.434	-0.623	0.78
03	-2.795	-3.803	-4.731	1.363
04	1.382	-4.929	-5.176	-5.999
05	1.385	-6.384	-6.384	-6.384
06	-6.384	-5.327	-5.327	1.383
07	-5.327	-5.505	1.167	-0.251
08	1.382	-5.999	-5.327	-4.731
09	-3.027	-2.554	1.227	-0.767
10	1.338	-3.168	-2.412	-2.89
11	-2.782	-2.821	-3.331	1.346
12	-2.319	-2.782	1.222	-0.805
13	-2.247	1.312	-2.455	-2.375
14	0.148	-1.268	0.817	-1.221

Standard thresholds

P-value	Threshold
0.001	-1.29594
0.0005	0.44311
0.0001	4.078715