PIT1.H12INVITRO.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	PIT1.H12INVITRO.1.S.B
Gene (human)	POU1F1 (GeneCards)
Gene synonyms (human)	GHF1, PIT1
Gene (mouse)	Pou1f1
Gene synonyms (mouse)	Pit-1, Pit1
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	15
Consensus	ndhATGAATWWKbhh
GC content	24.02%
Information content (bits; total / per base)	13.529 / 0.902
Data sources	HT-SELEX
Aligned words	6217

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.975	0.96	0.944	0.922	0.885	0.858
Overall, 3 experiments	best	0.983	0.972	0.963	0.947	0.918	0.895
Methyl HT-SELEX, 1 experiments	median	0.975	0.96	0.944	0.922	0.885	0.858
Methyl HT-SELEX, 1 experiments	best	0.975	0.96	0.944	0.922	0.885	0.858
Non-Methyl HT-SELEX, 2 experiments	median	0.976	0.962	0.943	0.923	0.873	0.853
Non-Methyl HT-SELEX, 2 experiments	best	0.983	0.972	0.963	0.947	0.918	0.895

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	POU {3.1.10} (TFClass)
TF subfamily	POU1 {3.1.10.1} (TFClass)
TFClass ID	TFClass: 3.1.10.1.1
HGNC	HGNC:9210
MGI	MGI:97588
EntrezGene (human)	GeneID:5449 (SSTAR profile)
EntrezGene (mouse)	GeneID:18736 (SSTAR profile)
UniProt ID (human)	PIT1_HUMAN
UniProt ID (mouse)	PIT1_MOUSE
UniProt AC (human)	P28069 (TFClass)
UniProt AC (mouse)	Q00286 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	2
Methyl-HT-SELEX	1

PCM	PIT1.H12INVITRO.1.S.B.pcm
PWM	PIT1.H12INVITRO.1.S.B.pwm
PFM	PIT1.H12INVITRO.1.S.B.pfm
Alignment	PIT1.H12INVITRO.1.S.B.words.tsv
Threshold to P-value map	PIT1.H12INVITRO.1.S.B.thr
Motif in other formats
JASPAR format	PIT1.H12INVITRO.1.S.B_jaspar_format.txt
MEME format	PIT1.H12INVITRO.1.S.B_meme_format.meme
Transfac format	PIT1.H12INVITRO.1.S.B_transfac_format.txt
Homer format	PIT1.H12INVITRO.1.S.B_homer_format_0.001.txt PIT1.H12INVITRO.1.S.B_homer_format_0.0005.txt PIT1.H12INVITRO.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1274.75	2149.75	1035.75	1756.75
02	990.75	613.75	1210.75	3401.75
03	1839.0	3020.0	479.0	879.0
04	5862.0	97.0	189.0	69.0
05	0.0	21.0	3.0	6193.0
06	1.0	0.0	4210.0	2006.0
07	5113.0	1104.0	0.0	0.0
08	6215.0	2.0	0.0	0.0
09	0.0	0.0	0.0	6217.0
10	4369.0	16.0	189.0	1643.0
11	4328.0	187.0	73.0	1629.0
12	999.0	376.0	1194.0	3648.0
13	942.0	1725.0	984.0	2566.0
14	3214.0	1292.0	514.0	1197.0
15	2956.75	884.75	827.75	1547.75

PFM

	A	C	G	T
01	0.205	0.346	0.167	0.283
02	0.159	0.099	0.195	0.547
03	0.296	0.486	0.077	0.141
04	0.943	0.016	0.03	0.011
05	0.0	0.003	0.0	0.996
06	0.0	0.0	0.677	0.323
07	0.822	0.178	0.0	0.0
08	1.0	0.0	0.0	0.0
09	0.0	0.0	0.0	1.0
10	0.703	0.003	0.03	0.264
11	0.696	0.03	0.012	0.262
12	0.161	0.06	0.192	0.587
13	0.152	0.277	0.158	0.413
14	0.517	0.208	0.083	0.193
15	0.476	0.142	0.133	0.249

PWM

	A	C	G	T
01	-0.198	0.324	-0.405	0.122
02	-0.449	-0.927	-0.249	0.783
03	0.168	0.664	-1.174	-0.569
04	1.326	-2.753	-2.097	-3.085
05	-6.569	-4.207	-5.705	1.381
06	-6.192	-6.569	0.996	0.255
07	1.19	-0.341	-6.569	-6.569
08	1.385	-5.919	-6.569	-6.569
09	-6.569	-6.569	-6.569	1.385
10	1.033	-4.45	-2.097	0.055
11	1.023	-2.107	-3.03	0.047
12	-0.441	-1.415	-0.263	0.852
13	-0.5	0.104	-0.456	0.501
14	0.726	-0.185	-1.104	-0.261
15	0.642	-0.562	-0.629	-0.004

Standard thresholds

P-value	Threshold
0.001	2.69316
0.0005	4.22191
0.0001	7.13621