MotifPHX2B.H12CORE.1.SM.B
Gene (human)PHOX2B
(GeneCards)
Gene synonyms (human)PMX2B
Gene (mouse)Phox2b
Gene synonyms (mouse)Pmx2b
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
B
Motif length11
ConsensusnvbTAATTvvn
GC content31.28%
Information content (bits; total / per base)10.654 / 0.969
Data sourcesHT-SELEX + Methyl-HT-SELEX
Aligned words7097

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 3 (21) 0.864 0.948 0.765 0.902 0.688 0.805 1.732 2.206 103.824 136.268

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 8 experiments median 0.955 0.926 0.925 0.893 0.842 0.801
best 0.978 0.959 0.974 0.954 0.953 0.931
Methyl HT-SELEX, 2 experiments median 0.94 0.9 0.908 0.867 0.8 0.782
best 0.967 0.94 0.931 0.903 0.841 0.788
Non-Methyl HT-SELEX, 6 experiments median 0.955 0.926 0.933 0.899 0.878 0.846
best 0.978 0.959 0.974 0.954 0.953 0.931
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyPaired-related HD {3.1.3} (TFClass)
TF subfamilyPHOX {3.1.3.18} (TFClass)
TFClass IDTFClass: 3.1.3.18.2
HGNCHGNC:9143
MGIMGI:1100882
EntrezGene (human)GeneID:8929
(SSTAR profile)
EntrezGene (mouse)GeneID:18935
(SSTAR profile)
UniProt ID (human)PHX2B_HUMAN
UniProt ID (mouse)PHX2B_MOUSE
UniProt AC (human)Q99453
(TFClass)
UniProt AC (mouse)O35690
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 3 human, 0 mouse
HT-SELEX 6
Methyl-HT-SELEX 2
PCM
ACGT
011967.02117.01780.01233.0
021629.02244.02638.0586.0
03134.02753.01293.02917.0
040.00.00.07097.0
057097.00.00.00.0
067097.00.00.00.0
070.00.00.07097.0
080.0522.016.06559.0
093509.0610.02468.0510.0
101570.752584.751981.75959.75
112088.01712.01697.01600.0
PFM
ACGT
010.2770.2980.2510.174
020.230.3160.3720.083
030.0190.3880.1820.411
040.00.00.01.0
051.00.00.00.0
061.00.00.00.0
070.00.00.01.0
080.00.0740.0020.924
090.4940.0860.3480.072
100.2210.3640.2790.135
110.2940.2410.2390.225
PWM
ACGT
010.1030.1760.003-0.363
02-0.0850.2350.396-1.105
03-2.5680.439-0.3160.497
04-6.686-6.686-6.6861.385
051.385-6.686-6.686-6.686
061.385-6.686-6.686-6.686
07-6.686-6.686-6.6861.385
08-6.686-1.22-4.581.307
090.681-1.0650.33-1.244
10-0.1220.3760.11-0.613
110.163-0.036-0.044-0.103
Standard thresholds
P-value Threshold
0.001 4.563505
0.0005 6.003935
0.0001 7.910445