MotifPHX2B.H12CORE.0.PSM.A
Gene (human)PHOX2B
(GeneCards)
Gene synonyms (human)PMX2B
Gene (mouse)Phox2b
Gene synonyms (mouse)Pmx2b
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length14
ConsensusnnTAATTARATTAn
GC content18.36%
Information content (bits; total / per base)18.86 / 1.347
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words8849

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 3 (21) 0.934 0.974 0.871 0.949 0.842 0.937 2.952 4.538 240.377 386.276

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 8 experiments median 0.99 0.982 0.977 0.971 0.859 0.843
best 1.0 1.0 1.0 0.999 0.995 0.995
Methyl HT-SELEX, 2 experiments median 0.956 0.929 0.932 0.904 0.794 0.795
best 1.0 0.999 0.979 0.978 0.834 0.806
Non-Methyl HT-SELEX, 6 experiments median 0.99 0.982 0.981 0.971 0.927 0.92
best 1.0 1.0 1.0 0.999 0.995 0.995
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyPaired-related HD {3.1.3} (TFClass)
TF subfamilyPHOX {3.1.3.18} (TFClass)
TFClass IDTFClass: 3.1.3.18.2
HGNCHGNC:9143
MGIMGI:1100882
EntrezGene (human)GeneID:8929
(SSTAR profile)
EntrezGene (mouse)GeneID:18935
(SSTAR profile)
UniProt ID (human)PHX2B_HUMAN
UniProt ID (mouse)PHX2B_MOUSE
UniProt AC (human)Q99453
(TFClass)
UniProt AC (mouse)O35690
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 3 human, 0 mouse
HT-SELEX 6
Methyl-HT-SELEX 2
PCM
ACGT
011818.752334.753107.751587.75
021683.253092.251713.252360.25
03168.081.015.08585.0
048749.05.086.09.0
058847.02.00.00.0
060.03.00.08846.0
072.027.014.08806.0
087372.0132.01181.0164.0
093590.0234.05020.05.0
108394.047.0351.057.0
113.06.019.08821.0
1267.0185.043.08554.0
138443.049.0107.0250.0
142315.01749.03136.01649.0
PFM
ACGT
010.2060.2640.3510.179
020.190.3490.1940.267
030.0190.0090.0020.97
040.9890.0010.010.001
051.00.00.00.0
060.00.00.01.0
070.00.0030.0020.995
080.8330.0150.1330.019
090.4060.0260.5670.001
100.9490.0050.040.006
110.00.0010.0020.997
120.0080.0210.0050.967
130.9540.0060.0120.028
140.2620.1980.3540.186
PWM
ACGT
01-0.1960.0540.34-0.331
02-0.2730.335-0.2550.065
03-2.565-3.281-4.8541.355
041.374-5.719-3.222-5.28
051.385-6.251-6.882-6.882
06-6.882-6.04-6.8821.385
07-6.251-4.326-4.9131.381
081.203-2.803-0.627-2.589
090.484-2.2380.819-5.719
101.333-3.805-1.836-3.621
11-6.04-5.59-4.6451.382
12-3.465-2.47-3.891.352
131.339-3.766-3.009-2.172
140.045-0.2350.349-0.293
Standard thresholds
P-value Threshold
0.001 -1.90169
0.0005 -0.08094
0.0001 3.74221