MotifPHX2A.H12CORE.0.PS.A
Gene (human)PHOX2A
(GeneCards)
Gene synonyms (human)ARIX, PMX2A
Gene (mouse)Phox2a
Gene synonyms (mouse)Arix, Phox2, Pmx2, Pmx2a
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length20
ConsensusvnnnnnbTAAYYhRATTAvn
GC content34.68%
Information content (bits; total / per base)13.725 / 0.686
Data sourcesChIP-Seq + HT-SELEX
Aligned words7335

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Mouse 1 (4) 0.888 0.931 0.818 0.871 0.839 0.901 3.084 3.503 94.562 164.796

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 4 experiments median 0.98 0.965 0.963 0.944 0.921 0.893
best 0.995 0.992 0.989 0.983 0.923 0.92
Methyl HT-SELEX, 1 experiments median 0.973 0.952 0.958 0.933 0.922 0.894
best 0.973 0.952 0.958 0.933 0.922 0.894
Non-Methyl HT-SELEX, 3 experiments median 0.986 0.977 0.967 0.953 0.92 0.892
best 0.995 0.992 0.989 0.983 0.923 0.92
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyPaired-related HD {3.1.3} (TFClass)
TF subfamilyPHOX {3.1.3.18} (TFClass)
TFClass IDTFClass: 3.1.3.18.1
HGNCHGNC:691
MGIMGI:106633
EntrezGene (human)GeneID:401
(SSTAR profile)
EntrezGene (mouse)GeneID:11859
(SSTAR profile)
UniProt ID (human)PHX2A_HUMAN
UniProt ID (mouse)PHX2A_MOUSE
UniProt AC (human)O14813
(TFClass)
UniProt AC (mouse)Q62066
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 0 human, 1 mouse
HT-SELEX 3
Methyl-HT-SELEX 1
PCM
ACGT
011456.53011.51476.51390.5
021664.02517.01684.01470.0
031543.02686.01619.01487.0
041630.02005.01951.01749.0
051879.02158.01862.01436.0
062084.01826.02202.01223.0
07886.02750.01810.01889.0
08397.0474.0223.06241.0
096270.0151.0649.0265.0
107072.0116.0111.036.0
11337.0926.0256.05816.0
1210.02794.0493.04038.0
132159.0843.0605.03728.0
145216.0266.01846.07.0
156705.062.0456.0112.0
160.08.00.07327.0
1785.0499.046.06705.0
185961.0117.0937.0320.0
191654.01512.03354.0815.0
201192.751756.752820.751564.75
PFM
ACGT
010.1990.4110.2010.19
020.2270.3430.230.2
030.210.3660.2210.203
040.2220.2730.2660.238
050.2560.2940.2540.196
060.2840.2490.30.167
070.1210.3750.2470.258
080.0540.0650.030.851
090.8550.0210.0880.036
100.9640.0160.0150.005
110.0460.1260.0350.793
120.0010.3810.0670.551
130.2940.1150.0820.508
140.7110.0360.2520.001
150.9140.0080.0620.015
160.00.0010.00.999
170.0120.0680.0060.914
180.8130.0160.1280.044
190.2250.2060.4570.111
200.1630.240.3850.213
PWM
ACGT
01-0.230.496-0.216-0.276
02-0.0970.316-0.085-0.221
03-0.1720.381-0.124-0.209
04-0.1180.0890.062-0.047
050.0240.1630.015-0.244
060.128-0.0040.183-0.404
07-0.7260.405-0.0130.03
08-1.526-1.349-2.0981.224
091.229-2.483-1.036-1.927
101.349-2.743-2.786-3.872
11-1.689-0.682-1.9611.153
12-5.0120.421-1.310.789
130.163-0.776-1.1060.709
141.045-1.9240.007-5.293
151.296-3.353-1.388-2.777
16-6.716-5.19-6.7161.384
17-3.047-1.298-3.6391.296
181.178-2.734-0.67-1.74
19-0.103-0.1930.603-0.809
20-0.429-0.0430.43-0.158
Standard thresholds
P-value Threshold
0.001 3.42236
0.0005 4.55416
0.0001 6.86796