| Motif | PAX6.H12RSNP.0.PSM.A |
| Gene (human) | PAX6 (GeneCards) |
| Gene synonyms (human) | AN2 |
| Gene (mouse) | Pax6 |
| Gene synonyms (mouse) | Pax-6, Sey |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | A |
| Motif | PAX6.H12RSNP.0.PSM.A |
| Gene (human) | PAX6 (GeneCards) |
| Gene synonyms (human) | AN2 |
| Gene (mouse) | Pax6 |
| Gene synonyms (mouse) | Pax-6, Sey |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | A |
| Motif length | 18 |
| Consensus | ndhRCGCdTvAnTRMnYn |
| GC content | 49.3% |
| Information content (bits; total / per base) | 10.631 / 0.591 |
| Data sources | ChIP-Seq + HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 6792 |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 1 (7) | 0.82 | 0.838 | 0.74 | 0.751 | 0.739 | 0.763 | 2.491 | 2.592 | 233.62 | 256.886 |
| Mouse | 6 (39) | 0.799 | 0.853 | 0.711 | 0.78 | 0.716 | 0.788 | 2.293 | 2.914 | 92.886 | 215.886 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 6 experiments | median | 0.981 | 0.97 | 0.949 | 0.931 | 0.878 | 0.86 |
| best | 0.989 | 0.983 | 0.977 | 0.964 | 0.95 | 0.932 | |
| Methyl HT-SELEX, 2 experiments | median | 0.981 | 0.97 | 0.949 | 0.931 | 0.878 | 0.86 |
| best | 0.982 | 0.974 | 0.963 | 0.944 | 0.923 | 0.899 | |
| Non-Methyl HT-SELEX, 4 experiments | median | 0.915 | 0.91 | 0.827 | 0.827 | 0.76 | 0.762 |
| best | 0.989 | 0.983 | 0.977 | 0.964 | 0.95 | 0.932 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 2 | 0.688 | 0.362 | 0.632 | 0.47 |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Paired box factors {3.2} (TFClass) |
| TF family | PD+HD {3.2.1} (TFClass) |
| TF subfamily | PAX4-like {3.2.1.2} (TFClass) |
| TFClass ID | TFClass: 3.2.1.2.2 |
| HGNC | HGNC:8620 |
| MGI | MGI:97490 |
| EntrezGene (human) | GeneID:5080 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:18508 (SSTAR profile) |
| UniProt ID (human) | PAX6_HUMAN |
| UniProt ID (mouse) | PAX6_MOUSE |
| UniProt AC (human) | P26367 (TFClass) |
| UniProt AC (mouse) | P63015 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 1 human, 6 mouse |
| HT-SELEX | 4 |
| Methyl-HT-SELEX | 2 |
| PCM | PAX6.H12RSNP.0.PSM.A.pcm |
| PWM | PAX6.H12RSNP.0.PSM.A.pwm |
| PFM | PAX6.H12RSNP.0.PSM.A.pfm |
| Alignment | PAX6.H12RSNP.0.PSM.A.words.tsv |
| Threshold to P-value map | PAX6.H12RSNP.0.PSM.A.thr |
| Motif in other formats | |
| JASPAR format | PAX6.H12RSNP.0.PSM.A_jaspar_format.txt |
| MEME format | PAX6.H12RSNP.0.PSM.A_meme_format.meme |
| Transfac format | PAX6.H12RSNP.0.PSM.A_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 1827.0 | 1635.0 | 1462.0 | 1868.0 |
| 02 | 1040.25 | 727.25 | 1423.25 | 3601.25 |
| 03 | 1253.0 | 2949.0 | 270.0 | 2320.0 |
| 04 | 5336.0 | 426.0 | 683.0 | 347.0 |
| 05 | 235.0 | 5221.0 | 89.0 | 1247.0 |
| 06 | 156.0 | 162.0 | 6333.0 | 141.0 |
| 07 | 220.0 | 5704.0 | 825.0 | 43.0 |
| 08 | 2608.0 | 667.0 | 1135.0 | 2382.0 |
| 09 | 41.0 | 907.0 | 39.0 | 5805.0 |
| 10 | 721.0 | 2475.0 | 3056.0 | 540.0 |
| 11 | 5508.0 | 394.0 | 878.0 | 12.0 |
| 12 | 1426.0 | 1617.0 | 1480.0 | 2269.0 |
| 13 | 53.0 | 1063.0 | 324.0 | 5352.0 |
| 14 | 2169.0 | 246.0 | 3541.0 | 836.0 |
| 15 | 2855.0 | 2640.0 | 1227.0 | 70.0 |
| 16 | 1690.0 | 1680.0 | 1966.0 | 1456.0 |
| 17 | 259.75 | 3221.75 | 699.75 | 2610.75 |
| 18 | 1985.0 | 1623.0 | 1482.0 | 1702.0 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.269 | 0.241 | 0.215 | 0.275 |
| 02 | 0.153 | 0.107 | 0.21 | 0.53 |
| 03 | 0.184 | 0.434 | 0.04 | 0.342 |
| 04 | 0.786 | 0.063 | 0.101 | 0.051 |
| 05 | 0.035 | 0.769 | 0.013 | 0.184 |
| 06 | 0.023 | 0.024 | 0.932 | 0.021 |
| 07 | 0.032 | 0.84 | 0.121 | 0.006 |
| 08 | 0.384 | 0.098 | 0.167 | 0.351 |
| 09 | 0.006 | 0.134 | 0.006 | 0.855 |
| 10 | 0.106 | 0.364 | 0.45 | 0.08 |
| 11 | 0.811 | 0.058 | 0.129 | 0.002 |
| 12 | 0.21 | 0.238 | 0.218 | 0.334 |
| 13 | 0.008 | 0.157 | 0.048 | 0.788 |
| 14 | 0.319 | 0.036 | 0.521 | 0.123 |
| 15 | 0.42 | 0.389 | 0.181 | 0.01 |
| 16 | 0.249 | 0.247 | 0.289 | 0.214 |
| 17 | 0.038 | 0.474 | 0.103 | 0.384 |
| 18 | 0.292 | 0.239 | 0.218 | 0.251 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.073 | -0.038 | -0.149 | 0.095 |
| 02 | -0.489 | -0.846 | -0.176 | 0.751 |
| 03 | -0.303 | 0.551 | -1.832 | 0.312 |
| 04 | 1.144 | -1.379 | -0.909 | -1.583 |
| 05 | -1.97 | 1.122 | -2.925 | -0.308 |
| 06 | -2.375 | -2.337 | 1.315 | -2.474 |
| 07 | -2.035 | 1.211 | -0.72 | -3.627 |
| 08 | 0.429 | -0.932 | -0.402 | 0.338 |
| 09 | -3.673 | -0.626 | -3.72 | 1.228 |
| 10 | -0.855 | 0.376 | 0.587 | -1.143 |
| 11 | 1.176 | -1.457 | -0.658 | -4.785 |
| 12 | -0.174 | -0.049 | -0.137 | 0.29 |
| 13 | -3.427 | -0.468 | -1.651 | 1.147 |
| 14 | 0.245 | -1.924 | 0.734 | -0.707 |
| 15 | 0.519 | 0.441 | -0.324 | -3.159 |
| 16 | -0.005 | -0.011 | 0.146 | -0.154 |
| 17 | -1.87 | 0.64 | -0.885 | 0.43 |
| 18 | 0.156 | -0.045 | -0.136 | 0.002 |
| P-value | Threshold |
|---|---|
| 0.001 | 4.55871 |
| 0.0005 | 5.43231 |
| 0.0001 | 7.22266 |