MotifPAX6.H12INVIVO.0.PSM.A
Gene (human)PAX6
(GeneCards)
Gene synonyms (human)AN2
Gene (mouse)Pax6
Gene synonyms (mouse)Pax-6, Sey
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length19
ConsensusbYKYhYRShTSAnTRvnYh
GC content48.3%
Information content (bits; total / per base)11.036 / 0.581
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words1001

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 1 (7) 0.868 0.876 0.809 0.819 0.841 0.852 3.287 3.431 279.377 310.367
Mouse 6 (39) 0.811 0.895 0.739 0.831 0.784 0.867 2.666 3.541 91.721 272.62

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 6 experiments median 0.958 0.938 0.906 0.878 0.816 0.795
best 0.978 0.963 0.963 0.942 0.928 0.902
Methyl HT-SELEX, 2 experiments median 0.958 0.938 0.906 0.878 0.816 0.795
best 0.96 0.943 0.924 0.891 0.86 0.828
Non-Methyl HT-SELEX, 4 experiments median 0.894 0.888 0.798 0.798 0.725 0.728
best 0.978 0.963 0.963 0.942 0.928 0.902

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.654 0.382 0.621 0.444
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classPaired box factors {3.2} (TFClass)
TF familyPD+HD {3.2.1} (TFClass)
TF subfamilyPAX4-like {3.2.1.2} (TFClass)
TFClass IDTFClass: 3.2.1.2.2
HGNCHGNC:8620
MGIMGI:97490
EntrezGene (human)GeneID:5080
(SSTAR profile)
EntrezGene (mouse)GeneID:18508
(SSTAR profile)
UniProt ID (human)PAX6_HUMAN
UniProt ID (mouse)PAX6_MOUSE
UniProt AC (human)P26367
(TFClass)
UniProt AC (mouse)P63015
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 1 human, 6 mouse
HT-SELEX 4
Methyl-HT-SELEX 2
PCM
ACGT
01146.0290.0188.0377.0
0277.0285.060.0579.0
0376.062.0100.0763.0
0430.0425.038.0508.0
05443.0443.046.069.0
0681.0480.012.0428.0
07253.019.0703.026.0
0820.0672.0293.016.0
09259.0266.057.0419.0
1027.0162.018.0794.0
1130.0504.0438.029.0
12795.023.0159.024.0
13151.0301.0276.0273.0
1432.098.029.0842.0
15202.018.0647.0134.0
16392.0340.0254.015.0
17313.0290.0206.0192.0
1837.0588.035.0341.0
19373.0289.072.0267.0
PFM
ACGT
010.1460.290.1880.377
020.0770.2850.060.578
030.0760.0620.10.762
040.030.4250.0380.507
050.4430.4430.0460.069
060.0810.480.0120.428
070.2530.0190.7020.026
080.020.6710.2930.016
090.2590.2660.0570.419
100.0270.1620.0180.793
110.030.5030.4380.029
120.7940.0230.1590.024
130.1510.3010.2760.273
140.0320.0980.0290.841
150.2020.0180.6460.134
160.3920.340.2540.015
170.3130.290.2060.192
180.0370.5870.0350.341
190.3730.2890.0720.267
PWM
ACGT
01-0.5340.146-0.2840.407
02-1.1630.129-1.4070.835
03-1.176-1.375-0.9071.11
04-2.0720.527-1.8470.705
050.5680.568-1.664-1.271
06-1.1140.648-2.910.534
070.011-2.4981.028-2.207
08-2.4510.9830.157-2.654
090.0340.061-1.4560.513
10-2.171-0.431-2.5471.15
11-2.0720.6970.557-2.104
121.151-2.321-0.45-2.282
13-0.5010.1830.0970.086
14-2.011-0.927-2.1041.208
15-0.213-2.5470.946-0.619
160.4460.3050.015-2.712
170.2220.146-0.193-0.263
18-1.8730.85-1.9260.308
190.3970.143-1.2290.064
Standard thresholds
P-value Threshold
0.001 4.48806
0.0005 5.35746
0.0001 7.16296