MotifPAX6.H12INVITRO.0.PSM.A
Gene (human)PAX6
(GeneCards)
Gene synonyms (human)AN2
Gene (mouse)Pax6
Gene synonyms (mouse)Pax-6, Sey
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length18
ConsensusnKhRCGCdTSAnYRvnbn
GC content50.07%
Information content (bits; total / per base)11.082 / 0.616
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words7374

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 1 (7) 0.829 0.843 0.744 0.757 0.737 0.76 2.467 2.574 237.509 265.032
Mouse 6 (39) 0.805 0.842 0.716 0.784 0.717 0.774 2.276 3.067 94.959 211.06

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 6 experiments median 0.985 0.976 0.956 0.941 0.882 0.869
best 0.989 0.983 0.978 0.966 0.953 0.936
Methyl HT-SELEX, 2 experiments median 0.985 0.976 0.956 0.941 0.887 0.871
best 0.985 0.979 0.97 0.954 0.933 0.912
Non-Methyl HT-SELEX, 4 experiments median 0.916 0.911 0.827 0.828 0.76 0.762
best 0.989 0.983 0.978 0.966 0.953 0.936

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.674 0.356 0.639 0.468
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classPaired box factors {3.2} (TFClass)
TF familyPD+HD {3.2.1} (TFClass)
TF subfamilyPAX4-like {3.2.1.2} (TFClass)
TFClass IDTFClass: 3.2.1.2.2
HGNCHGNC:8620
MGIMGI:97490
EntrezGene (human)GeneID:5080
(SSTAR profile)
EntrezGene (mouse)GeneID:18508
(SSTAR profile)
UniProt ID (human)PAX6_HUMAN
UniProt ID (mouse)PAX6_MOUSE
UniProt AC (human)P26367
(TFClass)
UniProt AC (mouse)P63015
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 1 human, 6 mouse
HT-SELEX 4
Methyl-HT-SELEX 2
PCM
ACGT
011772.751946.751543.752110.75
02832.5481.51697.54362.5
031338.02870.0190.02976.0
045924.0482.0720.0248.0
05201.05996.049.01128.0
06150.083.07084.057.0
07121.06291.0919.043.0
083232.0456.0924.02762.0
09130.0928.059.06257.0
10497.02341.03958.0578.0
115791.0408.01119.056.0
121990.01668.01821.01895.0
13141.02010.0392.04831.0
141858.0281.04308.0927.0
153477.02218.01474.0205.0
162509.01921.01412.01532.0
17487.53994.5794.52097.5
182248.01884.01731.01511.0
PFM
ACGT
010.240.2640.2090.286
020.1130.0650.230.592
030.1810.3890.0260.404
040.8030.0650.0980.034
050.0270.8130.0070.153
060.020.0110.9610.008
070.0160.8530.1250.006
080.4380.0620.1250.375
090.0180.1260.0080.849
100.0670.3170.5370.078
110.7850.0550.1520.008
120.270.2260.2470.257
130.0190.2730.0530.655
140.2520.0380.5840.126
150.4720.3010.20.028
160.340.2610.1910.208
170.0660.5420.1080.284
180.3050.2550.2350.205
PWM
ACGT
01-0.0390.054-0.1770.135
02-0.794-1.339-0.0820.861
03-0.320.442-2.2620.478
041.167-1.338-0.938-1.998
05-2.2061.179-3.584-0.49
06-2.495-3.0751.345-3.439
07-2.7071.227-0.695-3.709
080.561-1.393-0.690.404
09-2.636-0.685-3.4061.221
10-1.3080.2390.763-1.157
111.144-1.504-0.498-3.456
120.076-0.1-0.0120.028
13-2.5560.086-1.5440.963
140.008-1.8740.848-0.686
150.6340.185-0.223-2.187
160.3080.041-0.266-0.185
17-1.3270.773-0.840.129
180.1980.022-0.063-0.199
Standard thresholds
P-value Threshold
0.001 4.44191
0.0005 5.34451
0.0001 7.19846