| Motif | PAX6.H12CORE.0.PSM.A |
| Gene (human) | PAX6 (GeneCards) |
| Gene synonyms (human) | AN2 |
| Gene (mouse) | Pax6 |
| Gene synonyms (mouse) | Pax-6, Sey |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | A |
| Motif | PAX6.H12CORE.0.PSM.A |
| Gene (human) | PAX6 (GeneCards) |
| Gene synonyms (human) | AN2 |
| Gene (mouse) | Pax6 |
| Gene synonyms (mouse) | Pax-6, Sey |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | A |
| Motif length | 18 |
| Consensus | nKhRCGCdTSAnYRvnbn |
| GC content | 50.07% |
| Information content (bits; total / per base) | 11.082 / 0.616 |
| Data sources | ChIP-Seq + HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 7374 |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 1 (7) | 0.829 | 0.843 | 0.744 | 0.757 | 0.737 | 0.76 | 2.467 | 2.574 | 237.509 | 265.032 |
| Mouse | 6 (39) | 0.805 | 0.842 | 0.716 | 0.784 | 0.717 | 0.774 | 2.276 | 3.067 | 94.959 | 211.06 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 6 experiments | median | 0.985 | 0.976 | 0.956 | 0.941 | 0.882 | 0.869 |
| best | 0.989 | 0.983 | 0.978 | 0.966 | 0.953 | 0.936 | |
| Methyl HT-SELEX, 2 experiments | median | 0.985 | 0.976 | 0.956 | 0.941 | 0.887 | 0.871 |
| best | 0.985 | 0.979 | 0.97 | 0.954 | 0.933 | 0.912 | |
| Non-Methyl HT-SELEX, 4 experiments | median | 0.916 | 0.911 | 0.827 | 0.828 | 0.76 | 0.762 |
| best | 0.989 | 0.983 | 0.978 | 0.966 | 0.953 | 0.936 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 2 | 0.674 | 0.356 | 0.639 | 0.468 |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Paired box factors {3.2} (TFClass) |
| TF family | PD+HD {3.2.1} (TFClass) |
| TF subfamily | PAX4-like {3.2.1.2} (TFClass) |
| TFClass ID | TFClass: 3.2.1.2.2 |
| HGNC | HGNC:8620 |
| MGI | MGI:97490 |
| EntrezGene (human) | GeneID:5080 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:18508 (SSTAR profile) |
| UniProt ID (human) | PAX6_HUMAN |
| UniProt ID (mouse) | PAX6_MOUSE |
| UniProt AC (human) | P26367 (TFClass) |
| UniProt AC (mouse) | P63015 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 1 human, 6 mouse |
| HT-SELEX | 4 |
| Methyl-HT-SELEX | 2 |
| PCM | PAX6.H12CORE.0.PSM.A.pcm |
| PWM | PAX6.H12CORE.0.PSM.A.pwm |
| PFM | PAX6.H12CORE.0.PSM.A.pfm |
| Alignment | PAX6.H12CORE.0.PSM.A.words.tsv |
| Threshold to P-value map | PAX6.H12CORE.0.PSM.A.thr |
| Motif in other formats | |
| JASPAR format | PAX6.H12CORE.0.PSM.A_jaspar_format.txt |
| MEME format | PAX6.H12CORE.0.PSM.A_meme_format.meme |
| Transfac format | PAX6.H12CORE.0.PSM.A_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 1772.75 | 1946.75 | 1543.75 | 2110.75 |
| 02 | 832.5 | 481.5 | 1697.5 | 4362.5 |
| 03 | 1338.0 | 2870.0 | 190.0 | 2976.0 |
| 04 | 5924.0 | 482.0 | 720.0 | 248.0 |
| 05 | 201.0 | 5996.0 | 49.0 | 1128.0 |
| 06 | 150.0 | 83.0 | 7084.0 | 57.0 |
| 07 | 121.0 | 6291.0 | 919.0 | 43.0 |
| 08 | 3232.0 | 456.0 | 924.0 | 2762.0 |
| 09 | 130.0 | 928.0 | 59.0 | 6257.0 |
| 10 | 497.0 | 2341.0 | 3958.0 | 578.0 |
| 11 | 5791.0 | 408.0 | 1119.0 | 56.0 |
| 12 | 1990.0 | 1668.0 | 1821.0 | 1895.0 |
| 13 | 141.0 | 2010.0 | 392.0 | 4831.0 |
| 14 | 1858.0 | 281.0 | 4308.0 | 927.0 |
| 15 | 3477.0 | 2218.0 | 1474.0 | 205.0 |
| 16 | 2509.0 | 1921.0 | 1412.0 | 1532.0 |
| 17 | 487.5 | 3994.5 | 794.5 | 2097.5 |
| 18 | 2248.0 | 1884.0 | 1731.0 | 1511.0 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.24 | 0.264 | 0.209 | 0.286 |
| 02 | 0.113 | 0.065 | 0.23 | 0.592 |
| 03 | 0.181 | 0.389 | 0.026 | 0.404 |
| 04 | 0.803 | 0.065 | 0.098 | 0.034 |
| 05 | 0.027 | 0.813 | 0.007 | 0.153 |
| 06 | 0.02 | 0.011 | 0.961 | 0.008 |
| 07 | 0.016 | 0.853 | 0.125 | 0.006 |
| 08 | 0.438 | 0.062 | 0.125 | 0.375 |
| 09 | 0.018 | 0.126 | 0.008 | 0.849 |
| 10 | 0.067 | 0.317 | 0.537 | 0.078 |
| 11 | 0.785 | 0.055 | 0.152 | 0.008 |
| 12 | 0.27 | 0.226 | 0.247 | 0.257 |
| 13 | 0.019 | 0.273 | 0.053 | 0.655 |
| 14 | 0.252 | 0.038 | 0.584 | 0.126 |
| 15 | 0.472 | 0.301 | 0.2 | 0.028 |
| 16 | 0.34 | 0.261 | 0.191 | 0.208 |
| 17 | 0.066 | 0.542 | 0.108 | 0.284 |
| 18 | 0.305 | 0.255 | 0.235 | 0.205 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.039 | 0.054 | -0.177 | 0.135 |
| 02 | -0.794 | -1.339 | -0.082 | 0.861 |
| 03 | -0.32 | 0.442 | -2.262 | 0.478 |
| 04 | 1.167 | -1.338 | -0.938 | -1.998 |
| 05 | -2.206 | 1.179 | -3.584 | -0.49 |
| 06 | -2.495 | -3.075 | 1.345 | -3.439 |
| 07 | -2.707 | 1.227 | -0.695 | -3.709 |
| 08 | 0.561 | -1.393 | -0.69 | 0.404 |
| 09 | -2.636 | -0.685 | -3.406 | 1.221 |
| 10 | -1.308 | 0.239 | 0.763 | -1.157 |
| 11 | 1.144 | -1.504 | -0.498 | -3.456 |
| 12 | 0.076 | -0.1 | -0.012 | 0.028 |
| 13 | -2.556 | 0.086 | -1.544 | 0.963 |
| 14 | 0.008 | -1.874 | 0.848 | -0.686 |
| 15 | 0.634 | 0.185 | -0.223 | -2.187 |
| 16 | 0.308 | 0.041 | -0.266 | -0.185 |
| 17 | -1.327 | 0.773 | -0.84 | 0.129 |
| 18 | 0.198 | 0.022 | -0.063 | -0.199 |
| P-value | Threshold |
|---|---|
| 0.001 | 4.44191 |
| 0.0005 | 5.34451 |
| 0.0001 | 7.19846 |