P73.H12INVITRO.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	P73.H12INVITRO.0.PS.A
Gene (human)	TP73 (GeneCards)
Gene synonyms (human)	P73
Gene (mouse)	Tp73
Gene synonyms (mouse)	P73, Trp73
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	19
Consensus	ndCRWGYYbnRRCWTGThn
GC content	49.88%
Information content (bits; total / per base)	16.019 / 0.843
Data sources	ChIP-Seq + HT-SELEX
Aligned words	9239

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (21)	0.969	0.994	0.946	0.987	0.95	0.99	5.101	6.46	501.137	748.398

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	1.0	1.0	0.993	0.993	0.848	0.865
Non-Methyl HT-SELEX, 1 experiments	best	1.0	1.0	0.993	0.993	0.848	0.865

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	p53 domain factors {6.3} (TFClass)
TF family	p53-related {6.3.1} (TFClass)
TF subfamily	{6.3.1.0} (TFClass)
TFClass ID	TFClass: 6.3.1.0.3
HGNC	HGNC:12003
MGI	MGI:1336991
EntrezGene (human)	GeneID:7161 (SSTAR profile)
EntrezGene (mouse)	GeneID:22062 (SSTAR profile)
UniProt ID (human)	P73_HUMAN
UniProt ID (mouse)	P73_MOUSE
UniProt AC (human)	O15350 (TFClass)
UniProt AC (mouse)	Q9JJP2 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	0

PCM	P73.H12INVITRO.0.PS.A.pcm
PWM	P73.H12INVITRO.0.PS.A.pwm
PFM	P73.H12INVITRO.0.PS.A.pfm
Alignment	P73.H12INVITRO.0.PS.A.words.tsv
Threshold to P-value map	P73.H12INVITRO.0.PS.A.thr
Motif in other formats
JASPAR format	P73.H12INVITRO.0.PS.A_jaspar_format.txt
MEME format	P73.H12INVITRO.0.PS.A_meme_format.meme
Transfac format	P73.H12INVITRO.0.PS.A_transfac_format.txt
Homer format	P73.H12INVITRO.0.PS.A_homer_format_0.001.txt P73.H12INVITRO.0.PS.A_homer_format_0.0005.txt P73.H12INVITRO.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2208.25	1394.25	2815.25	2821.25
02	2996.75	1302.75	3479.75	1459.75
03	91.0	8990.0	66.0	92.0
04	5633.0	307.0	2760.0	539.0
05	1397.0	321.0	311.0	7210.0
06	132.0	107.0	8899.0	101.0
07	251.0	1925.0	149.0	6914.0
08	816.0	5612.0	250.0	2561.0
09	1442.0	3024.0	1592.0	3181.0
10	2465.0	1742.0	2658.0	2374.0
11	1887.0	374.0	5608.0	1370.0
12	6834.0	219.0	1865.0	321.0
13	11.0	9196.0	10.0	22.0
14	5292.0	310.0	118.0	3519.0
15	72.0	458.0	27.0	8682.0
16	48.0	44.0	9067.0	80.0
17	33.0	2379.0	108.0	6719.0
18	1086.25	4345.25	497.25	3310.25
19	1590.25	3068.25	2167.25	2413.25

PFM

	A	C	G	T
01	0.239	0.151	0.305	0.305
02	0.324	0.141	0.377	0.158
03	0.01	0.973	0.007	0.01
04	0.61	0.033	0.299	0.058
05	0.151	0.035	0.034	0.78
06	0.014	0.012	0.963	0.011
07	0.027	0.208	0.016	0.748
08	0.088	0.607	0.027	0.277
09	0.156	0.327	0.172	0.344
10	0.267	0.189	0.288	0.257
11	0.204	0.04	0.607	0.148
12	0.74	0.024	0.202	0.035
13	0.001	0.995	0.001	0.002
14	0.573	0.034	0.013	0.381
15	0.008	0.05	0.003	0.94
16	0.005	0.005	0.981	0.009
17	0.004	0.257	0.012	0.727
18	0.118	0.47	0.054	0.358
19	0.172	0.332	0.235	0.261

PWM

	A	C	G	T
01	-0.045	-0.504	0.198	0.2
02	0.26	-0.572	0.409	-0.458
03	-3.21	1.358	-3.522	-3.2
04	0.891	-2.012	0.178	-1.452
05	-0.502	-1.967	-1.999	1.138
06	-2.846	-3.052	1.348	-3.108
07	-2.211	-0.182	-2.727	1.096
08	-1.039	0.887	-2.215	0.103
09	-0.471	0.269	-0.372	0.32
10	0.065	-0.282	0.14	0.027
11	-0.202	-1.816	0.886	-0.522
12	1.084	-2.346	-0.214	-1.967
13	-5.159	1.381	-5.238	-4.556
14	0.829	-2.002	-2.956	0.421
15	-3.438	-1.614	-4.369	1.323
16	-3.828	-3.911	1.367	-3.336
17	-4.182	0.03	-3.043	1.067
18	-0.753	0.631	-1.532	0.36
19	-0.373	0.284	-0.064	0.044

Standard thresholds

P-value	Threshold
0.001	2.09346
0.0005	3.40276
0.0001	6.13051