P63.H12RSNP.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	P63.H12RSNP.0.PS.A
Gene (human)	TP63 (GeneCards)
Gene synonyms (human)	KET, P63, P73H, P73L, TP73L
Gene (mouse)	Tp63
Gene synonyms (mouse)	P63, P73l, Tp73l, Trp63
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	20
Consensus	ddRCAWGYhSWRRCWTGYhh
GC content	49.18%
Information content (bits; total / per base)	16.602 / 0.83
Data sources	ChIP-Seq + HT-SELEX
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	41 (268)	0.979	0.997	0.96	0.991	0.967	0.993	5.103	6.419	589.86	968.222
Mouse	3 (16)	0.92	0.961	0.874	0.922	0.894	0.939	4.007	4.48	332.129	392.854

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.629	0.645	0.557	0.573	0.527	0.541
Non-Methyl HT-SELEX, 1 experiments	best	0.629	0.645	0.557	0.573	0.527	0.541

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	9.988	42.599	0.436	0.298

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	p53 domain factors {6.3} (TFClass)
TF family	p53-related {6.3.1} (TFClass)
TF subfamily	{6.3.1.0} (TFClass)
TFClass ID	TFClass: 6.3.1.0.2
HGNC	HGNC:15979
MGI	MGI:1330810
EntrezGene (human)	GeneID:8626 (SSTAR profile)
EntrezGene (mouse)	GeneID:22061 (SSTAR profile)
UniProt ID (human)	P63_HUMAN
UniProt ID (mouse)	P63_MOUSE
UniProt AC (human)	Q9H3D4 (TFClass)
UniProt AC (mouse)	O88898 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	41 human, 3 mouse
HT-SELEX	1
Methyl-HT-SELEX	0

PCM	P63.H12RSNP.0.PS.A.pcm
PWM	P63.H12RSNP.0.PS.A.pwm
PFM	P63.H12RSNP.0.PS.A.pfm
Alignment	P63.H12RSNP.0.PS.A.words.tsv
Threshold to P-value map	P63.H12RSNP.0.PS.A.thr
Motif in other formats
JASPAR format	P63.H12RSNP.0.PS.A_jaspar_format.txt
MEME format	P63.H12RSNP.0.PS.A_meme_format.meme
Transfac format	P63.H12RSNP.0.PS.A_transfac_format.txt
Homer format	P63.H12RSNP.0.PS.A_homer_format_0.001.txt P63.H12RSNP.0.PS.A_homer_format_0.0005.txt P63.H12RSNP.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	386.0	161.0	283.0	170.0
02	382.0	50.0	397.0	171.0
03	527.0	2.0	406.0	65.0
04	1.0	995.0	0.0	4.0
05	824.0	42.0	60.0	74.0
06	420.0	2.0	85.0	493.0
07	0.0	0.0	1000.0	0.0
08	98.0	327.0	0.0	575.0
09	174.0	417.0	96.0	313.0
10	15.0	690.0	176.0	119.0
11	554.0	171.0	14.0	261.0
12	273.0	49.0	597.0	81.0
13	561.0	2.0	320.0	117.0
14	0.0	1000.0	0.0	0.0
15	555.0	70.0	5.0	370.0
16	70.0	61.0	51.0	818.0
17	3.0	2.0	994.0	1.0
18	92.0	448.0	1.0	459.0
19	238.0	305.0	65.0	392.0
20	175.0	336.0	156.0	333.0

PFM

	A	C	G	T
01	0.386	0.161	0.283	0.17
02	0.382	0.05	0.397	0.171
03	0.527	0.002	0.406	0.065
04	0.001	0.995	0.0	0.004
05	0.824	0.042	0.06	0.074
06	0.42	0.002	0.085	0.493
07	0.0	0.0	1.0	0.0
08	0.098	0.327	0.0	0.575
09	0.174	0.417	0.096	0.313
10	0.015	0.69	0.176	0.119
11	0.554	0.171	0.014	0.261
12	0.273	0.049	0.597	0.081
13	0.561	0.002	0.32	0.117
14	0.0	1.0	0.0	0.0
15	0.555	0.07	0.005	0.37
16	0.07	0.061	0.051	0.818
17	0.003	0.002	0.994	0.001
18	0.092	0.448	0.001	0.459
19	0.238	0.305	0.065	0.392
20	0.175	0.336	0.156	0.333

PWM

	A	C	G	T
01	0.432	-0.436	0.123	-0.382
02	0.422	-1.582	0.46	-0.377
03	0.742	-4.213	0.482	-1.328
04	-4.525	1.376	-4.982	-3.783
05	1.188	-1.75	-1.406	-1.201
06	0.516	-4.213	-1.066	0.676
07	-4.982	-4.982	1.381	-4.982
08	-0.926	0.267	-4.982	0.829
09	-0.359	0.509	-0.946	0.223
10	-2.711	1.011	-0.348	-0.735
11	0.792	-0.377	-2.773	0.043
12	0.087	-1.602	0.866	-1.113
13	0.804	-4.213	0.245	-0.752
14	-4.982	1.381	-4.982	-4.982
15	0.794	-1.255	-3.622	0.39
16	-1.255	-1.39	-1.563	1.181
17	-3.975	-4.213	1.375	-4.525
18	-0.988	0.58	-4.525	0.604
19	-0.049	0.198	-1.328	0.447
20	-0.354	0.294	-0.467	0.285

Standard thresholds

P-value	Threshold
0.001	1.50921
0.0005	2.96026
0.0001	5.98016