P63.H12INVIVO.1.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	P63.H12INVIVO.1.PS.A
Gene (human)	TP63 (GeneCards)
Gene synonyms (human)	KET, P63, P73H, P73L, TP73L
Gene (mouse)	Tp63
Gene synonyms (mouse)	P63, P73l, Tp73l, Trp63
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	12
Consensus	hbdRRCWTGYhb
GC content	53.71%
Information content (bits; total / per base)	10.269 / 0.856
Data sources	ChIP-Seq + HT-SELEX
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	41 (268)	0.867	0.908	0.744	0.85	0.763	0.823	2.212	2.938	271.594	483.959
Mouse	3 (16)	0.813	0.844	0.675	0.694	0.715	0.758	1.968	2.089	125.67	163.921

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.646	0.624	0.58	0.572	0.544	0.545
Non-Methyl HT-SELEX, 1 experiments	best	0.646	0.624	0.58	0.572	0.544	0.545

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	4.91	25.011	0.308	0.24

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	p53 domain factors {6.3} (TFClass)
TF family	p53-related {6.3.1} (TFClass)
TF subfamily	{6.3.1.0} (TFClass)
TFClass ID	TFClass: 6.3.1.0.2
HGNC	HGNC:15979
MGI	MGI:1330810
EntrezGene (human)	GeneID:8626 (SSTAR profile)
EntrezGene (mouse)	GeneID:22061 (SSTAR profile)
UniProt ID (human)	P63_HUMAN
UniProt ID (mouse)	P63_MOUSE
UniProt AC (human)	Q9H3D4 (TFClass)
UniProt AC (mouse)	O88898 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	41 human, 3 mouse
HT-SELEX	1
Methyl-HT-SELEX	0

PCM	P63.H12INVIVO.1.PS.A.pcm
PWM	P63.H12INVIVO.1.PS.A.pwm
PFM	P63.H12INVIVO.1.PS.A.pfm
Alignment	P63.H12INVIVO.1.PS.A.words.tsv
Threshold to P-value map	P63.H12INVIVO.1.PS.A.thr
Motif in other formats
JASPAR format	P63.H12INVIVO.1.PS.A_jaspar_format.txt
MEME format	P63.H12INVIVO.1.PS.A_meme_format.meme
Transfac format	P63.H12INVIVO.1.PS.A_transfac_format.txt
Homer format	P63.H12INVIVO.1.PS.A_homer_format_0.001.txt P63.H12INVIVO.1.PS.A_homer_format_0.0005.txt P63.H12INVIVO.1.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	164.0	547.0	91.0	198.0
02	80.0	501.0	145.0	274.0
03	494.0	47.0	261.0	198.0
04	195.0	33.0	756.0	16.0
05	515.0	4.0	439.0	42.0
06	2.0	997.0	0.0	1.0
07	499.0	119.0	8.0	374.0
08	8.0	6.0	7.0	979.0
09	0.0	1.0	998.0	1.0
10	16.0	459.0	3.0	522.0
11	190.0	330.0	49.0	431.0
12	106.0	397.0	247.0	250.0

PFM

	A	C	G	T
01	0.164	0.547	0.091	0.198
02	0.08	0.501	0.145	0.274
03	0.494	0.047	0.261	0.198
04	0.195	0.033	0.756	0.016
05	0.515	0.004	0.439	0.042
06	0.002	0.997	0.0	0.001
07	0.499	0.119	0.008	0.374
08	0.008	0.006	0.007	0.979
09	0.0	0.001	0.998	0.001
10	0.016	0.459	0.003	0.522
11	0.19	0.33	0.049	0.431
12	0.106	0.397	0.247	0.25

PWM

	A	C	G	T
01	-0.418	0.779	-0.999	-0.231
02	-1.125	0.692	-0.54	0.091
03	0.678	-1.642	0.043	-0.231
04	-0.247	-1.981	1.102	-2.653
05	0.719	-3.783	0.56	-1.75
06	-4.213	1.378	-4.982	-4.525
07	0.688	-0.735	-3.253	0.401
08	-3.253	-3.484	-3.362	1.36
09	-4.982	-4.525	1.379	-4.525
10	-2.653	0.604	-3.975	0.733
11	-0.272	0.276	-1.602	0.542
12	-0.849	0.46	-0.012	0.0

Standard thresholds

P-value	Threshold
0.001	4.77186
0.0005	5.823815
0.0001	7.56919